Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4FQ9

Crystal Structure of 3-hydroxydecanoyl-Acyl Carrier Protein Dehydratase (FabA) from Pseudomonas aeruginosa

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006633	biological_process	fatty acid biosynthetic process
A	0006636	biological_process	unsaturated fatty acid biosynthetic process
A	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
A	0034017	molecular_function	trans-2-decenoyl-acyl-carrier-protein isomerase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006633	biological_process	fatty acid biosynthetic process
B	0006636	biological_process	unsaturated fatty acid biosynthetic process
B	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
B	0034017	molecular_function	trans-2-decenoyl-acyl-carrier-protein isomerase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006633	biological_process	fatty acid biosynthetic process
C	0006636	biological_process	unsaturated fatty acid biosynthetic process
C	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
C	0034017	molecular_function	trans-2-decenoyl-acyl-carrier-protein isomerase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006633	biological_process	fatty acid biosynthetic process
D	0006636	biological_process	unsaturated fatty acid biosynthetic process
D	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
D	0034017	molecular_function	trans-2-decenoyl-acyl-carrier-protein isomerase activity
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006633	biological_process	fatty acid biosynthetic process
E	0006636	biological_process	unsaturated fatty acid biosynthetic process
E	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
E	0034017	molecular_function	trans-2-decenoyl-acyl-carrier-protein isomerase activity
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006633	biological_process	fatty acid biosynthetic process
F	0006636	biological_process	unsaturated fatty acid biosynthetic process
F	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
F	0034017	molecular_function	trans-2-decenoyl-acyl-carrier-protein isomerase activity
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006633	biological_process	fatty acid biosynthetic process
G	0006636	biological_process	unsaturated fatty acid biosynthetic process
G	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
G	0034017	molecular_function	trans-2-decenoyl-acyl-carrier-protein isomerase activity
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006633	biological_process	fatty acid biosynthetic process
H	0006636	biological_process	unsaturated fatty acid biosynthetic process
H	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
H	0034017	molecular_function	trans-2-decenoyl-acyl-carrier-protein isomerase activity
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006633	biological_process	fatty acid biosynthetic process
I	0006636	biological_process	unsaturated fatty acid biosynthetic process
I	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
I	0034017	molecular_function	trans-2-decenoyl-acyl-carrier-protein isomerase activity
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006633	biological_process	fatty acid biosynthetic process
J	0006636	biological_process	unsaturated fatty acid biosynthetic process
J	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
J	0034017	molecular_function	trans-2-decenoyl-acyl-carrier-protein isomerase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 A 201

Chain	Residue
A	ASP84
A	TRP87
A	GLN88
A	GOL204
A	HOH342
A	HOH343
A	HOH344
B	HIS70

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 A 202

Chain	Residue
A	PHE71
A	GOL203
A	HOH346
A	HOH347
B	ASP84
B	TRP87
B	GLN88
A	HIS70

site_id	AC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GOL A 203

Chain	Residue
A	HIS70
A	PHE71
A	VAL76
A	MET77
A	GLY79
A	PO4202
A	HOH341
A	HOH346
B	ARG104
B	ALA105
B	HOH250

site_id	AC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL A 204

Chain	Residue
A	ARG104
A	ALA105
A	PO4201
A	HOH304
A	HOH317
A	HOH344
B	HIS70
B	PHE71
B	MET77
B	GLY79

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 C 201

Chain	Residue
C	ASP84
C	TRP87
C	GLN88
C	HOH325
C	HOH358
C	HOH382
D	HIS70
D	GOL202

site_id	AC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL C 202

Chain	Residue
C	GLN4
C	ALA6
C	ASP11
G	GLU72
H	GLY18
H	PRO23
H	GLY24
H	GLN27
H	ARG102
H	HOH313

site_id	AC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL C 203

Chain	Residue
C	HIS70
C	PHE71
C	VAL76
C	MET77
C	GLY79
C	HOH380
D	ARG104
D	ALA105
D	PO4201
D	HOH335

site_id	AC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PO4 D 201

Chain	Residue
C	HIS70
C	GOL203
D	ASP84
D	TRP87
D	GLN88
D	HOH328
D	HOH335
D	HOH368
D	HOH370

site_id	AC9
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL D 202

Chain	Residue
C	ARG104
C	ALA105
C	PO4201
C	HOH358
C	HOH381
D	HIS70
D	PHE71
D	PRO78
D	GLY79
D	HOH367

site_id	BC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 E 201

Chain	Residue
E	ASP84
E	TRP87
E	GLN88
E	GOL203
E	HOH363
E	HOH364
E	HOH366
F	HIS70

site_id	BC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL E 202

Chain	Residue
G	ARG102
G	HOH343
H	GLU72
E	GLN4
E	ALA6
E	ASP11
G	GLY18
G	PRO23
G	GLY24
G	GLN27

site_id	BC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL E 203

Chain	Residue
E	ARG104
E	ALA105
E	PO4201
E	HOH362
E	HOH366
F	HIS70
F	PHE71
F	VAL76
F	GLY79

site_id	BC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE GOL E 204

Chain	Residue
E	HIS70
E	PHE71
E	MET77
E	PRO78
E	GLY79
E	HOH361
F	ARG104
F	ALA105
F	PHE171
F	PO4201
F	HOH320
F	HOH361

site_id	BC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PO4 F 201

Chain	Residue
E	HIS70
E	PHE71
E	GOL204
F	ASP84
F	TRP87
F	GLN88
F	HOH320
F	HOH359
F	HOH360
F	HOH361

site_id	BC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PO4 G 201

Chain	Residue
G	PRO29
G	ASP84
G	TRP87
G	GLN88
G	GOL202
G	HOH369
G	HOH385
G	HOH386
H	HIS70
H	PHE71

site_id	BC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL G 202

Chain	Residue
G	ARG104
G	ALA105
G	PHE171
G	PO4201
G	HOH384
G	HOH386
H	HIS70
H	PHE71
H	VAL76
H	GLY79

site_id	BC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL G 203

Chain	Residue
G	HIS70
G	PHE71
G	GLY79
G	PHE113
G	HOH315
H	ARG104
H	ALA105
H	PO4201

site_id	BC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 H 201

Chain	Residue
G	HIS70
G	GOL203
H	PRO29
H	ASP84
H	TRP87
H	GLN88
H	HOH331
H	HOH356

site_id	CC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PO4 I 201

Chain	Residue
I	PRO29
I	ASP84
I	TRP87
I	GLN88
I	GOL202
I	HOH344
I	HOH355
J	HIS70
J	PHE71

site_id	CC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL I 202

Chain	Residue
I	ARG104
I	ALA105
I	PHE171
I	PO4201
I	HOH356
J	HIS70
J	MET77
J	GLY79
J	PHE113

site_id	CC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PO4 J 201

Chain	Residue
I	HIS70
I	PHE71
J	PRO29
J	ASP84
J	TRP87
J	GLN88
J	GOL202
J	HOH342
J	HOH343
J	HOH344

site_id	CC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL J 202

Chain	Residue
I	HIS70
I	GLY79
J	ARG104
J	ALA105
J	PO4201
J	HOH315
J	HOH342

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)