Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4FP9

Human MTERF4-NSUN4 protein complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000957	biological_process	mitochondrial RNA catabolic process
A	0001510	biological_process	RNA methylation
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0006364	biological_process	rRNA processing
A	0006396	biological_process	RNA processing
A	0008168	molecular_function	methyltransferase activity
A	0008173	molecular_function	RNA methyltransferase activity
A	0008649	molecular_function	rRNA methyltransferase activity
A	0008757	molecular_function	S-adenosylmethionine-dependent methyltransferase activity
A	0009383	molecular_function	rRNA (cytosine-C5-)-methyltransferase activity
A	0016740	molecular_function	transferase activity
A	0019843	molecular_function	rRNA binding
A	0031167	biological_process	rRNA methylation
A	0032259	biological_process	methylation
A	0042254	biological_process	ribosome biogenesis
A	0062152	molecular_function	mRNA (cytidine-5-)-methyltransferase activity
A	1900864	biological_process	mitochondrial RNA modification
A	1902775	biological_process	mitochondrial large ribosomal subunit assembly
A	1990400	molecular_function	mitochondrial ribosomal large subunit rRNA binding
B	0003676	molecular_function	nucleic acid binding
B	0043231	cellular_component	intracellular membrane-bounded organelle
C	0000957	biological_process	mitochondrial RNA catabolic process
C	0001510	biological_process	RNA methylation
C	0003723	molecular_function	RNA binding
C	0005515	molecular_function	protein binding
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0006364	biological_process	rRNA processing
C	0006396	biological_process	RNA processing
C	0008168	molecular_function	methyltransferase activity
C	0008173	molecular_function	RNA methyltransferase activity
C	0008649	molecular_function	rRNA methyltransferase activity
C	0008757	molecular_function	S-adenosylmethionine-dependent methyltransferase activity
C	0009383	molecular_function	rRNA (cytosine-C5-)-methyltransferase activity
C	0016740	molecular_function	transferase activity
C	0019843	molecular_function	rRNA binding
C	0031167	biological_process	rRNA methylation
C	0032259	biological_process	methylation
C	0042254	biological_process	ribosome biogenesis
C	0062152	molecular_function	mRNA (cytidine-5-)-methyltransferase activity
C	1900864	biological_process	mitochondrial RNA modification
C	1902775	biological_process	mitochondrial large ribosomal subunit assembly
C	1990400	molecular_function	mitochondrial ribosomal large subunit rRNA binding
D	0000957	biological_process	mitochondrial RNA catabolic process
D	0001510	biological_process	RNA methylation
D	0003723	molecular_function	RNA binding
D	0005515	molecular_function	protein binding
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0006364	biological_process	rRNA processing
D	0006396	biological_process	RNA processing
D	0008168	molecular_function	methyltransferase activity
D	0008173	molecular_function	RNA methyltransferase activity
D	0008649	molecular_function	rRNA methyltransferase activity
D	0008757	molecular_function	S-adenosylmethionine-dependent methyltransferase activity
D	0009383	molecular_function	rRNA (cytosine-C5-)-methyltransferase activity
D	0016740	molecular_function	transferase activity
D	0019843	molecular_function	rRNA binding
D	0031167	biological_process	rRNA methylation
D	0032259	biological_process	methylation
D	0042254	biological_process	ribosome biogenesis
D	0062152	molecular_function	mRNA (cytidine-5-)-methyltransferase activity
D	1900864	biological_process	mitochondrial RNA modification
D	1902775	biological_process	mitochondrial large ribosomal subunit assembly
D	1990400	molecular_function	mitochondrial ribosomal large subunit rRNA binding
E	0003676	molecular_function	nucleic acid binding
E	0043231	cellular_component	intracellular membrane-bounded organelle
F	0000957	biological_process	mitochondrial RNA catabolic process
F	0001510	biological_process	RNA methylation
F	0003723	molecular_function	RNA binding
F	0005515	molecular_function	protein binding
F	0005739	cellular_component	mitochondrion
F	0005759	cellular_component	mitochondrial matrix
F	0006364	biological_process	rRNA processing
F	0006396	biological_process	RNA processing
F	0008168	molecular_function	methyltransferase activity
F	0008173	molecular_function	RNA methyltransferase activity
F	0008649	molecular_function	rRNA methyltransferase activity
F	0008757	molecular_function	S-adenosylmethionine-dependent methyltransferase activity
F	0009383	molecular_function	rRNA (cytosine-C5-)-methyltransferase activity
F	0016740	molecular_function	transferase activity
F	0019843	molecular_function	rRNA binding
F	0031167	biological_process	rRNA methylation
F	0032259	biological_process	methylation
F	0042254	biological_process	ribosome biogenesis
F	0062152	molecular_function	mRNA (cytidine-5-)-methyltransferase activity
F	1900864	biological_process	mitochondrial RNA modification
F	1902775	biological_process	mitochondrial large ribosomal subunit assembly
F	1990400	molecular_function	mitochondrial ribosomal large subunit rRNA binding
G	0003676	molecular_function	nucleic acid binding
G	0043231	cellular_component	intracellular membrane-bounded organelle
H	0003676	molecular_function	nucleic acid binding
H	0043231	cellular_component	intracellular membrane-bounded organelle

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE SAM A 401

Chain	Residue
A	CYS181
A	ARG209
A	ASP237
A	GLY238
A	ASP255
A	PRO257
A	LEU291
A	ALA182
A	ALA183
A	PRO184
A	GLY185
A	GLY186
A	LYS187
A	ASP204
A	LEU205

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 402

Chain	Residue
A	ARG345
A	ARG346

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 401

Chain	Residue
B	ARG190
B	GLN191

site_id	AC4
Number of Residues	15
Details	BINDING SITE FOR RESIDUE SAM C 401

Chain	Residue
C	CYS181
C	ALA182
C	ALA183
C	PRO184
C	GLY185
C	GLY186
C	LYS187
C	ASP204
C	LEU205
C	ARG209
C	ASP237
C	GLY238
C	ASP255
C	PRO257
C	LEU291

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 C 402

Chain	Residue
C	ARG345
C	ARG346

site_id	AC6
Number of Residues	15
Details	BINDING SITE FOR RESIDUE SAM D 401

Chain	Residue
D	CYS181
D	ALA182
D	ALA183
D	PRO184
D	GLY185
D	GLY186
D	LYS187
D	ASP204
D	LEU205
D	ARG209
D	ASP237
D	GLY238
D	ASP255
D	PRO257
D	LEU291

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 402

Chain	Residue
B	LYS161
D	SER140
D	ARG141
G	ARG322

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 D 403

Chain	Residue
D	ARG345
D	ARG346

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 404

Chain	Residue
D	GLN71
D	HIS263
D	HIS266

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 E 401

Chain	Residue
E	TYR238
E	LYS244
E	HIS245

site_id	BC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE SAM F 401

Chain	Residue
F	CYS181
F	ALA182
F	ALA183
F	PRO184
F	GLY185
F	GLY186
F	LYS187
F	ASP204
F	LEU205
F	ARG209
F	ASP237
F	GLY238
F	ASP255
F	PRO257
F	LEU291

site_id	BC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 F 402

Chain	Residue
F	ARG345
F	ARG346

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PROSITE-ProRule","id":"PRU01023","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"22949673","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23022348","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22949673","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4FP9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22949673","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23022348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4FP9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FZV","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01023","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"22949673","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23022348","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4FP9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FZV","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01023","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	120
Details	Repeat: {"description":"MTERF 1","evidences":[{"source":"PubMed","id":"23022348","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	108
Details	Repeat: {"description":"MTERF 2","evidences":[{"source":"PubMed","id":"23022348","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	120
Details	Repeat: {"description":"MTERF 3","evidences":[{"source":"PubMed","id":"23022348","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	100
Details	Repeat: {"description":"MTERF 4","evidences":[{"source":"PubMed","id":"23022348","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	112
Details	Repeat: {"description":"MTERF 5","evidences":[{"source":"PubMed","id":"23022348","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	68
Details	Region: {"description":"Dimerization with NSUN4"}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)