Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4FP9

Human MTERF4-NSUN4 protein complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001510	biological_process	RNA methylation
A	0005515	molecular_function	protein binding
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0005762	cellular_component	mitochondrial large ribosomal subunit
A	0006364	biological_process	rRNA processing
A	0008168	molecular_function	methyltransferase activity
A	0008173	molecular_function	RNA methyltransferase activity
A	0008649	molecular_function	rRNA methyltransferase activity
A	0009383	molecular_function	rRNA (cytosine-C5-)-methyltransferase activity
A	0016428	molecular_function	tRNA (cytidine-5-)-methyltransferase activity
A	0019843	molecular_function	rRNA binding
A	0031167	biological_process	rRNA methylation
A	0032259	biological_process	methylation
A	0042254	biological_process	ribosome biogenesis
B	0003690	molecular_function	double-stranded DNA binding
B	0006355	biological_process	regulation of DNA-templated transcription
C	0001510	biological_process	RNA methylation
C	0005515	molecular_function	protein binding
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0005762	cellular_component	mitochondrial large ribosomal subunit
C	0006364	biological_process	rRNA processing
C	0008168	molecular_function	methyltransferase activity
C	0008173	molecular_function	RNA methyltransferase activity
C	0008649	molecular_function	rRNA methyltransferase activity
C	0009383	molecular_function	rRNA (cytosine-C5-)-methyltransferase activity
C	0016428	molecular_function	tRNA (cytidine-5-)-methyltransferase activity
C	0019843	molecular_function	rRNA binding
C	0031167	biological_process	rRNA methylation
C	0032259	biological_process	methylation
C	0042254	biological_process	ribosome biogenesis
D	0001510	biological_process	RNA methylation
D	0005515	molecular_function	protein binding
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0005762	cellular_component	mitochondrial large ribosomal subunit
D	0006364	biological_process	rRNA processing
D	0008168	molecular_function	methyltransferase activity
D	0008173	molecular_function	RNA methyltransferase activity
D	0008649	molecular_function	rRNA methyltransferase activity
D	0009383	molecular_function	rRNA (cytosine-C5-)-methyltransferase activity
D	0016428	molecular_function	tRNA (cytidine-5-)-methyltransferase activity
D	0019843	molecular_function	rRNA binding
D	0031167	biological_process	rRNA methylation
D	0032259	biological_process	methylation
D	0042254	biological_process	ribosome biogenesis
E	0003690	molecular_function	double-stranded DNA binding
E	0006355	biological_process	regulation of DNA-templated transcription
F	0001510	biological_process	RNA methylation
F	0005515	molecular_function	protein binding
F	0005739	cellular_component	mitochondrion
F	0005759	cellular_component	mitochondrial matrix
F	0005762	cellular_component	mitochondrial large ribosomal subunit
F	0006364	biological_process	rRNA processing
F	0008168	molecular_function	methyltransferase activity
F	0008173	molecular_function	RNA methyltransferase activity
F	0008649	molecular_function	rRNA methyltransferase activity
F	0009383	molecular_function	rRNA (cytosine-C5-)-methyltransferase activity
F	0016428	molecular_function	tRNA (cytidine-5-)-methyltransferase activity
F	0019843	molecular_function	rRNA binding
F	0031167	biological_process	rRNA methylation
F	0032259	biological_process	methylation
F	0042254	biological_process	ribosome biogenesis
G	0003690	molecular_function	double-stranded DNA binding
G	0006355	biological_process	regulation of DNA-templated transcription
H	0003690	molecular_function	double-stranded DNA binding
H	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE SAM A 401

Chain	Residue
A	CYS181
A	ARG209
A	ASP237
A	GLY238
A	ASP255
A	PRO257
A	LEU291
A	ALA182
A	ALA183
A	PRO184
A	GLY185
A	GLY186
A	LYS187
A	ASP204
A	LEU205

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 402

Chain	Residue
A	ARG345
A	ARG346

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 401

Chain	Residue
B	ARG190
B	GLN191

site_id	AC4
Number of Residues	15
Details	BINDING SITE FOR RESIDUE SAM C 401

Chain	Residue
C	CYS181
C	ALA182
C	ALA183
C	PRO184
C	GLY185
C	GLY186
C	LYS187
C	ASP204
C	LEU205
C	ARG209
C	ASP237
C	GLY238
C	ASP255
C	PRO257
C	LEU291

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 C 402

Chain	Residue
C	ARG345
C	ARG346

site_id	AC6
Number of Residues	15
Details	BINDING SITE FOR RESIDUE SAM D 401

Chain	Residue
D	CYS181
D	ALA182
D	ALA183
D	PRO184
D	GLY185
D	GLY186
D	LYS187
D	ASP204
D	LEU205
D	ARG209
D	ASP237
D	GLY238
D	ASP255
D	PRO257
D	LEU291

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 402

Chain	Residue
B	LYS161
D	SER140
D	ARG141
G	ARG322

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 D 403

Chain	Residue
D	ARG345
D	ARG346

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 404

Chain	Residue
D	GLN71
D	HIS263
D	HIS266

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 E 401

Chain	Residue
E	TYR238
E	LYS244
E	HIS245

site_id	BC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE SAM F 401

Chain	Residue
F	CYS181
F	ALA182
F	ALA183
F	PRO184
F	GLY185
F	GLY186
F	LYS187
F	ASP204
F	LEU205
F	ARG209
F	ASP237
F	GLY238
F	ASP255
F	PRO257
F	LEU291

site_id	BC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 F 402

Chain	Residue
F	ARG345
F	ARG346

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Nucleophile => ECO:0000255\|PROSITE-ProRule:PRU01023, ECO:0000269\|PubMed:22949673

Chain	Residue	Details
A	CYS310
C	CYS310
D	CYS310
F	CYS310

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING:

Chain	Residue	Details
A	CYS181
C	CYS181
D	CYS181
F	CYS181

site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU01023, ECO:0000269\|PubMed:23022348

Chain	Residue	Details
A	ASP237
A	ASP255
C	ASP237
C	ASP255
D	ASP237
D	ASP255
F	ASP237
F	ASP255

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	SER206
C	SER206
D	SER206
F	SER206

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)