4FN6
Structural Characterization of Thiaminase type II TenA from Staphylococcus aureus
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005829 | cellular_component | cytosol |
| A | 0006772 | biological_process | thiamine metabolic process |
| A | 0009228 | biological_process | thiamine biosynthetic process |
| A | 0009229 | biological_process | thiamine diphosphate biosynthetic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0050334 | molecular_function | thiaminase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006772 | biological_process | thiamine metabolic process |
| B | 0009228 | biological_process | thiamine biosynthetic process |
| B | 0009229 | biological_process | thiamine diphosphate biosynthetic process |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0050334 | molecular_function | thiaminase activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0006772 | biological_process | thiamine metabolic process |
| C | 0009228 | biological_process | thiamine biosynthetic process |
| C | 0009229 | biological_process | thiamine diphosphate biosynthetic process |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0050334 | molecular_function | thiaminase activity |
| D | 0005829 | cellular_component | cytosol |
| D | 0006772 | biological_process | thiamine metabolic process |
| D | 0009228 | biological_process | thiamine biosynthetic process |
| D | 0009229 | biological_process | thiamine diphosphate biosynthetic process |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0050334 | molecular_function | thiaminase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT A 301 |
| Chain | Residue |
| A | SER190 |
| A | ASP191 |
| A | HOH431 |
| C | SER188 |
| C | MET189 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT A 302 |
| Chain | Residue |
| A | ASP44 |
| A | TYR47 |
| A | CME137 |
| A | GLU208 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 303 |
| Chain | Residue |
| A | ASP21 |
| A | ASP22 |
| A | ASN213 |
| A | HOH423 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT B 301 |
| Chain | Residue |
| B | LYS6 |
| B | GLN9 |
| B | ALA10 |
| B | LYS198 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE ACT B 302 |
| Chain | Residue |
| B | ASP21 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 303 |
| Chain | Residue |
| B | HIS122 |
| B | SER123 |
| B | GLU125 |
| C | LYS61 |
| C | ALA121 |
| C | HIS122 |
| C | ARG124 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL C 301 |
| Chain | Residue |
| C | ASP44 |
| C | PHE51 |
| C | TYR113 |
| C | CME137 |
| C | TYR141 |
| C | GLU208 |
| site_id | AC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE GOL C 302 |
| Chain | Residue |
| C | TRP106 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACT C 303 |
| Chain | Residue |
| B | SER190 |
| C | SER188 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACT C 304 |
| Chain | Residue |
| C | MET78 |
| C | CME137 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT D 301 |
| Chain | Residue |
| D | ASP44 |
| D | PHE51 |
| D | CME137 |
| D | TYR141 |
| D | GLU208 |
| site_id | BC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE ACT D 302 |
| Chain | Residue |
| D | GLU157 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT D 303 |
| Chain | Residue |
| A | HIS122 |
| A | SER123 |
| D | SER123 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"UniProtKB","id":"P25052","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"P25052","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P25052","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Site: {"description":"Increases nucleophilicity of active site Cys","evidences":[{"source":"UniProtKB","id":"P25052","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
