4FN4

short-chain NAD(H)-dependent dehydrogenase/reductase from Sulfolobus acidocaldarius

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0016491	molecular_function	oxidoreductase activity
B	0000166	molecular_function	nucleotide binding
B	0016491	molecular_function	oxidoreductase activity
C	0000166	molecular_function	nucleotide binding
C	0016491	molecular_function	oxidoreductase activity
D	0000166	molecular_function	nucleotide binding
D	0016491	molecular_function	oxidoreductase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	30
Details	BINDING SITE FOR RESIDUE NAD A 501

Chain	Residue
A	GLY15
A	VAL66
A	ASN92
A	ALA93
A	GLY94
A	ILE95
A	THR143
A	ALA144
A	SER145
A	TYR158
A	LYS162
A	SER18
A	PRO188
A	GLY189
A	VAL191
A	THR193
A	ASN194
A	ILE195
A	GOL502
A	HOH606
A	HOH620
A	HOH631
A	GLY19
A	HOH658
A	ILE20
A	GLU39
A	LEU40
A	ARG44
A	ALA64
A	ASP65

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 502

Chain	Residue
A	MET96
A	TYR158
A	GLY189
A	GLY196
A	NAD501
A	HOH677

---

site_id	AC3
Number of Residues	28
Details	BINDING SITE FOR RESIDUE NAD B 501

Chain	Residue
B	GLY15
B	SER18
B	GLY19
B	ILE20
B	GLU39
B	LEU40
B	ARG44
B	ALA64
B	ASP65
B	VAL66
B	ASN92
B	ALA93
B	GLY94
B	THR143
B	ALA144
B	TYR158
B	LYS162
B	PRO188
B	GLY189
B	VAL191
B	THR193
B	ASN194
B	ILE195
B	HOH605
B	HOH656
B	HOH721
B	HOH745
B	HOH748

---

site_id	AC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL B 503

Chain	Residue
A	LYS212
B	ALA173
B	ALA174
B	GLY177
B	ASP178
B	ASN242
D	SER217
D	ARG219
D	GLY250
D	LEU255

---

site_id	AC5
Number of Residues	30
Details	BINDING SITE FOR RESIDUE NAD C 501

Chain	Residue
C	GOL502
C	HOH638
C	HOH640
C	HOH659
C	HOH773
C	GLY15
C	GLY17
C	SER18
C	GLY19
C	ILE20
C	GLU39
C	LEU40
C	ARG44
C	ALA64
C	ASP65
C	VAL66
C	ASN92
C	ALA93
C	GLY94
C	THR143
C	ALA144
C	SER145
C	TYR158
C	LYS162
C	PRO188
C	GLY189
C	VAL191
C	THR193
C	ASN194
C	ILE195

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL C 502

Chain	Residue
C	MET96
C	TYR158
C	GLY189
C	GLY196
C	NAD501
C	HOH665
C	HOH773

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 503

Chain	Residue
C	SER106
C	GLU108
C	LEU109
C	ARG112

---

site_id	AC8
Number of Residues	29
Details	BINDING SITE FOR RESIDUE NAD D 501

Chain	Residue
D	GLY15
D	SER18
D	GLY19
D	ILE20
D	GLU39
D	LEU40
D	ARG44
D	ALA64
D	ASP65
D	VAL66
D	ASN92
D	ALA93
D	GLY94
D	THR143
D	ALA144
D	SER145
D	TYR158
D	LYS162
D	PRO188
D	GLY189
D	VAL191
D	THR193
D	ASN194
D	ILE195
D	GOL502
D	HOH612
D	HOH636
D	HOH666
D	HOH669

---

site_id	AC9
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL D 502

Chain	Residue
D	MET96
D	SER145
D	TYR158
D	GLY189
D	GLY196
D	LEU197
D	NAD501
D	HOH631
D	HOH669
D	HOH750

---

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL D 503

Chain	Residue
D	GLU104
D	HOH627

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Functional Information from PROSITE/UniProt

site_id	PS00061
Number of Residues	29
Details	ADH_SHORT Short-chain dehydrogenases/reductases family signature. SiagirggfaGapYTVAKHGLiGLTrSIA

Chain	Residue	Details
A	SER145-ALA173

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