4FN4
short-chain NAD(H)-dependent dehydrogenase/reductase from Sulfolobus acidocaldarius
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0048038 | molecular_function | quinone binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0048038 | molecular_function | quinone binding |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0006633 | biological_process | fatty acid biosynthetic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| C | 0048038 | molecular_function | quinone binding |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0006633 | biological_process | fatty acid biosynthetic process |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| D | 0048038 | molecular_function | quinone binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 30 |
| Details | BINDING SITE FOR RESIDUE NAD A 501 |
| Chain | Residue |
| A | GLY15 |
| A | VAL66 |
| A | ASN92 |
| A | ALA93 |
| A | GLY94 |
| A | ILE95 |
| A | THR143 |
| A | ALA144 |
| A | SER145 |
| A | TYR158 |
| A | LYS162 |
| A | SER18 |
| A | PRO188 |
| A | GLY189 |
| A | VAL191 |
| A | THR193 |
| A | ASN194 |
| A | ILE195 |
| A | GOL502 |
| A | HOH606 |
| A | HOH620 |
| A | HOH631 |
| A | GLY19 |
| A | HOH658 |
| A | ILE20 |
| A | GLU39 |
| A | LEU40 |
| A | ARG44 |
| A | ALA64 |
| A | ASP65 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 502 |
| Chain | Residue |
| A | MET96 |
| A | TYR158 |
| A | GLY189 |
| A | GLY196 |
| A | NAD501 |
| A | HOH677 |
| site_id | AC3 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE NAD B 501 |
| Chain | Residue |
| B | GLY15 |
| B | SER18 |
| B | GLY19 |
| B | ILE20 |
| B | GLU39 |
| B | LEU40 |
| B | ARG44 |
| B | ALA64 |
| B | ASP65 |
| B | VAL66 |
| B | ASN92 |
| B | ALA93 |
| B | GLY94 |
| B | THR143 |
| B | ALA144 |
| B | TYR158 |
| B | LYS162 |
| B | PRO188 |
| B | GLY189 |
| B | VAL191 |
| B | THR193 |
| B | ASN194 |
| B | ILE195 |
| B | HOH605 |
| B | HOH656 |
| B | HOH721 |
| B | HOH745 |
| B | HOH748 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL B 503 |
| Chain | Residue |
| A | LYS212 |
| B | ALA173 |
| B | ALA174 |
| B | GLY177 |
| B | ASP178 |
| B | ASN242 |
| D | SER217 |
| D | ARG219 |
| D | GLY250 |
| D | LEU255 |
| site_id | AC5 |
| Number of Residues | 30 |
| Details | BINDING SITE FOR RESIDUE NAD C 501 |
| Chain | Residue |
| C | GOL502 |
| C | HOH638 |
| C | HOH640 |
| C | HOH659 |
| C | HOH773 |
| C | GLY15 |
| C | GLY17 |
| C | SER18 |
| C | GLY19 |
| C | ILE20 |
| C | GLU39 |
| C | LEU40 |
| C | ARG44 |
| C | ALA64 |
| C | ASP65 |
| C | VAL66 |
| C | ASN92 |
| C | ALA93 |
| C | GLY94 |
| C | THR143 |
| C | ALA144 |
| C | SER145 |
| C | TYR158 |
| C | LYS162 |
| C | PRO188 |
| C | GLY189 |
| C | VAL191 |
| C | THR193 |
| C | ASN194 |
| C | ILE195 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL C 502 |
| Chain | Residue |
| C | MET96 |
| C | TYR158 |
| C | GLY189 |
| C | GLY196 |
| C | NAD501 |
| C | HOH665 |
| C | HOH773 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 503 |
| Chain | Residue |
| C | SER106 |
| C | GLU108 |
| C | LEU109 |
| C | ARG112 |
| site_id | AC8 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE NAD D 501 |
| Chain | Residue |
| D | GLY15 |
| D | SER18 |
| D | GLY19 |
| D | ILE20 |
| D | GLU39 |
| D | LEU40 |
| D | ARG44 |
| D | ALA64 |
| D | ASP65 |
| D | VAL66 |
| D | ASN92 |
| D | ALA93 |
| D | GLY94 |
| D | THR143 |
| D | ALA144 |
| D | SER145 |
| D | TYR158 |
| D | LYS162 |
| D | PRO188 |
| D | GLY189 |
| D | VAL191 |
| D | THR193 |
| D | ASN194 |
| D | ILE195 |
| D | GOL502 |
| D | HOH612 |
| D | HOH636 |
| D | HOH666 |
| D | HOH669 |
| site_id | AC9 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL D 502 |
| Chain | Residue |
| D | MET96 |
| D | SER145 |
| D | TYR158 |
| D | GLY189 |
| D | GLY196 |
| D | LEU197 |
| D | NAD501 |
| D | HOH631 |
| D | HOH669 |
| D | HOH750 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL D 503 |
| Chain | Residue |
| D | GLU104 |
| D | HOH627 |
Functional Information from PROSITE/UniProt
| site_id | PS00061 |
| Number of Residues | 29 |
| Details | ADH_SHORT Short-chain dehydrogenases/reductases family signature. SiagirggfaGapYTVAKHGLiGLTrSIA |
| Chain | Residue | Details |
| A | SER145-ALA173 |
