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4FLH

Crystal structure of human PI3K-gamma in complex with AMG511

Functional Information from GO Data
ChainGOidnamespacecontents
A0016301molecular_functionkinase activity
A0046854biological_processphosphatidylinositol phosphate biosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 A 1201
ChainResidue
APRO206
ALEU207
ATRP212
ALYS288
ALYS1066

site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 A 1202
ChainResidue
ATRP576
AARG579
ALYS606

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 A 1203
ChainResidue
APHE694
APHE698
AGLN846
AARG849
ALEU657

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 A 1204
ChainResidue
AARG947
AHIS948
AASN951
ATRP1086
ALEU1090

site_idAC5
Number of Residues16
DetailsBINDING SITE FOR RESIDUE 14K A 1205
ChainResidue
ALYS802
AMET804
AALA805
AILE831
ALYS833
AASP841
ATYR867
AGLU880
AILE881
AVAL882
ATHR887
AMET953
AILE963
AASP964
AHOH1318
AHOH1320

Functional Information from PROSITE/UniProt
site_idPS00915
Number of Residues15
DetailsPI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. FKhg.DDLRQDmlilQ
ChainResidueDetails
APHE832-GLN846

site_idPS00916
Number of Residues21
DetailsPI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. ScAgycVatFVLgIgDRHndN
ChainResidueDetails
ASER931-ASN951

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AGLY829
ALEU864
APHE961

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by PKA => ECO:0000250|UniProtKB:Q9JHG7
ChainResidueDetails
ATHR1024

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine; by autocatalysis => ECO:0000269|PubMed:12502714
ChainResidueDetails
ASER1101

226707

PDB entries from 2024-10-30

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