4FJO

Structure of the Rev1 CTD-Rev3/7-Pol kappa RIR complex

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0000785	cellular_component	chromatin
C	0001558	biological_process	regulation of cell growth
C	0002208	biological_process	somatic diversification of immunoglobulins involved in immune response
C	0003714	molecular_function	transcription corepressor activity
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005680	cellular_component	anaphase-promoting complex
C	0005694	cellular_component	chromosome
C	0005737	cellular_component	cytoplasm
C	0005819	cellular_component	spindle
C	0006281	biological_process	DNA repair
C	0006302	biological_process	double-strand break repair
C	0006351	biological_process	DNA-templated transcription
C	0006974	biological_process	DNA damage response
C	0007015	biological_process	actin filament organization
C	0008432	molecular_function	JUN kinase binding
C	0010628	biological_process	positive regulation of gene expression
C	0010717	biological_process	regulation of epithelial to mesenchymal transition
C	0010718	biological_process	positive regulation of epithelial to mesenchymal transition
C	0010719	biological_process	negative regulation of epithelial to mesenchymal transition
C	0010944	biological_process	negative regulation of transcription by competitive promoter binding
C	0016035	cellular_component	zeta DNA polymerase complex
C	0019985	biological_process	translesion synthesis
C	0030674	molecular_function	protein-macromolecule adaptor activity
C	0033138	biological_process	positive regulation of peptidyl-serine phosphorylation
C	0035861	cellular_component	site of double-strand break
C	0042177	biological_process	negative regulation of protein catabolic process
C	0042276	biological_process	error-prone translesion synthesis
C	0042772	biological_process	DNA damage response, signal transduction resulting in transcription
C	0043247	biological_process	telomere maintenance in response to DNA damage
C	0045830	biological_process	positive regulation of isotype switching
C	0045893	biological_process	positive regulation of DNA-templated transcription
C	0051301	biological_process	cell division
C	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
C	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
C	0090734	cellular_component	site of DNA damage
C	1901203	biological_process	positive regulation of extracellular matrix assembly
C	1904667	biological_process	negative regulation of ubiquitin protein ligase activity
C	2000042	biological_process	negative regulation of double-strand break repair via homologous recombination
C	2000048	biological_process	negative regulation of cell-cell adhesion mediated by cadherin
C	2001034	biological_process	positive regulation of double-strand break repair via nonhomologous end joining

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 1301

Chain	Residue
A	LYS1167
A	LYS1171
A	TYR1210
A	ARG1213

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PO4 C 301

Chain	Residue
C	GLU81
C	LYS82
C	HIS151
D	ARG1870
D	HIS1873

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 C 302

Chain	Residue
A	ASP1228
A	ASP1232
C	HIS180
C	MET181
C	HOH403
C	HOH458
D	ARG1870

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 C 303

Chain	Residue
C	HIS118
C	SER194
C	ASP195
C	ILE196

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PO4 C 304

Chain	Residue
A	LEU1231
A	GLN1235
C	HIS182
C	ASP183
C	PO4307

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PO4 C 305

Chain	Residue
C	MET1
C	TYR32
C	VAL33
C	GLU35
C	VAL39
C	ASP134

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 C 306

Chain	Residue
C	ASN10
C	GLU76
C	LYS77
C	HOH444

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 C 307

Chain	Residue
A	VAL1248
C	HIS180
C	HIS182
C	PO4304

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PO4 C 308

Chain	Residue
A	GLU1202
A	ASP1205
A	HOH1418
C	LYS129
C	PRO188
C	LEU189

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	190
Details	Domain: {"description":"HORMA","evidences":[{"source":"PROSITE-ProRule","id":"PRU00109","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	134
Details	Region: {"description":"Mediates interaction with REV1 and REV3L and homodimerization","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---