4FJ6
Crystal structure of a glycoside hydrolase family 33, candidate sialidase (BDI_2946) from Parabacteroides distasonis ATCC 8503 at 1.90 A resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004308 | molecular_function | exo-alpha-sialidase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006689 | biological_process | ganglioside catabolic process |
| A | 0009313 | biological_process | oligosaccharide catabolic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016787 | molecular_function | hydrolase activity |
| B | 0004308 | molecular_function | exo-alpha-sialidase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006689 | biological_process | ganglioside catabolic process |
| B | 0009313 | biological_process | oligosaccharide catabolic process |
| B | 0016020 | cellular_component | membrane |
| B | 0016787 | molecular_function | hydrolase activity |
| C | 0004308 | molecular_function | exo-alpha-sialidase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006689 | biological_process | ganglioside catabolic process |
| C | 0009313 | biological_process | oligosaccharide catabolic process |
| C | 0016020 | cellular_component | membrane |
| C | 0016787 | molecular_function | hydrolase activity |
| D | 0004308 | molecular_function | exo-alpha-sialidase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006689 | biological_process | ganglioside catabolic process |
| D | 0009313 | biological_process | oligosaccharide catabolic process |
| D | 0016020 | cellular_component | membrane |
| D | 0016787 | molecular_function | hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 601 |
| Chain | Residue |
| A | SER98 |
| A | HIS99 |
| A | GLY503 |
| A | TRP504 |
| A | GLU522 |
| A | SER523 |
| A | HIS527 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 602 |
| Chain | Residue |
| A | ILE349 |
| A | ILE450 |
| A | LYS451 |
| A | HOH752 |
| A | HOH861 |
| A | HOH871 |
| A | HOH900 |
| A | GLU275 |
| A | ARG347 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 603 |
| Chain | Residue |
| A | ASP35 |
| A | ARG105 |
| A | GLY187 |
| A | VAL188 |
| A | GLN190 |
| A | HOH725 |
| A | HOH859 |
| A | HOH885 |
| A | HOH1165 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 604 |
| Chain | Residue |
| A | ARG200 |
| A | SER223 |
| A | VAL224 |
| A | TRP504 |
| A | HOH902 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 A 605 |
| Chain | Residue |
| A | LYS229 |
| A | LYS254 |
| A | HIS261 |
| A | HOH983 |
| A | HOH1065 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 A 606 |
| Chain | Residue |
| A | ARG26 |
| A | HIS89 |
| A | PHE90 |
| A | SER91 |
| A | HOH727 |
| A | HOH960 |
| A | HOH1167 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 A 607 |
| Chain | Residue |
| A | ARG200 |
| A | ARG411 |
| A | ARG475 |
| A | TYR506 |
| A | HOH902 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 A 608 |
| Chain | Residue |
| A | HIS384 |
| A | HIS386 |
| A | HOH1016 |
| A | HOH1103 |
| A | HOH1155 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 A 609 |
| Chain | Residue |
| A | ARG236 |
| A | GLU245 |
| A | LYS321 |
| A | HOH1097 |
| A | HOH1119 |
| A | HOH1159 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 601 |
| Chain | Residue |
| B | LYS50 |
| D | GLN49 |
| D | LYS50 |
| site_id | BC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL B 602 |
| Chain | Residue |
| B | GLU109 |
| site_id | BC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL B 603 |
| Chain | Residue |
| A | GLU109 |
| A | SER110 |
| B | LYS229 |
| B | LYS254 |
| B | HIS261 |
| B | HOH1062 |
| B | HOH1173 |
| B | HOH1174 |
| site_id | BC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 604 |
| Chain | Residue |
| B | GLU275 |
| B | ILE450 |
| B | LYS451 |
| B | HOH737 |
| B | HOH741 |
| B | HOH1017 |
| B | HOH1026 |
| site_id | BC5 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL B 605 |
| Chain | Residue |
| A | ASN168 |
| B | ASP35 |
| B | ARG105 |
| B | ILE186 |
| B | GLY187 |
| B | VAL188 |
| B | GLN190 |
| B | HOH789 |
| B | HOH905 |
| B | HOH962 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 B 606 |
| Chain | Residue |
| B | ARG200 |
| B | ARG411 |
| B | ARG475 |
| B | TYR506 |
| B | HOH835 |
| site_id | BC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PO4 B 607 |
| Chain | Residue |
| B | HOH936 |
| B | HOH1127 |
| B | ARG26 |
| B | HIS89 |
| B | PHE90 |
| B | SER91 |
| B | HOH780 |
| B | HOH850 |
| B | HOH920 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 B 608 |
| Chain | Residue |
| B | ARG236 |
| B | THR238 |
| B | GLU245 |
| B | LYS321 |
| site_id | BC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL C 601 |
| Chain | Residue |
| C | ASN103 |
| C | GLU109 |
| C | SER110 |
| C | HOH759 |
| C | HOH1069 |
| C | HOH1070 |
| site_id | CC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL C 602 |
| Chain | Residue |
| C | GLU275 |
| C | ILE349 |
| C | ILE450 |
| C | LYS451 |
| C | HOH792 |
| C | HOH910 |
| C | HOH988 |
| C | HOH1065 |
| site_id | CC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL C 603 |
| Chain | Residue |
| C | VAL93 |
| C | THR94 |
| C | LEU108 |
| C | TYR111 |
| C | HOH962 |
| C | HOH1179 |
| D | ASN292 |
| site_id | CC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PO4 C 604 |
| Chain | Residue |
| C | HIS261 |
| C | HOH768 |
| C | HOH1128 |
| site_id | CC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 C 605 |
| Chain | Residue |
| C | ARG200 |
| C | ASP225 |
| C | ARG411 |
| C | ARG475 |
| C | TYR506 |
| C | HOH779 |
| C | HOH975 |
| site_id | CC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PO4 C 606 |
| Chain | Residue |
| C | ARG26 |
| C | HIS89 |
| C | PHE90 |
| C | SER91 |
| C | HOH744 |
| C | HOH790 |
| C | HOH1002 |
| C | HOH1059 |
| site_id | CC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 C 607 |
| Chain | Residue |
| C | HIS384 |
| C | HIS386 |
| C | HOH832 |
| C | HOH871 |
| C | HOH1110 |
| site_id | CC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 C 608 |
| Chain | Residue |
| C | ARG390 |
| C | ARG414 |
| C | ARG437 |
| C | HOH1190 |
| site_id | CC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL D 601 |
| Chain | Residue |
| D | ARG236 |
| site_id | CC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL D 602 |
| Chain | Residue |
| D | GLU275 |
| D | ILE349 |
| D | ILE450 |
| D | LYS451 |
| D | HOH735 |
| D | HOH843 |
| D | HOH844 |
| D | HOH1008 |
| site_id | DC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL D 603 |
| Chain | Residue |
| C | ASN292 |
| D | VAL93 |
| D | THR94 |
| D | LEU108 |
| D | TYR111 |
| D | HOH834 |
| site_id | DC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL D 604 |
| Chain | Residue |
| D | ASP35 |
| D | ARG105 |
| D | GLY187 |
| D | VAL188 |
| D | ARG189 |
| D | ASP193 |
| D | HOH756 |
| D | HOH870 |
| D | HOH927 |
| site_id | DC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL D 605 |
| Chain | Residue |
| D | SER98 |
| D | HIS99 |
| D | GLY503 |
| D | TRP504 |
| D | GLU522 |
| D | SER523 |
| D | SER524 |
| D | ALA526 |
| D | HOH1162 |
| site_id | DC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL D 606 |
| Chain | Residue |
| C | HOH1068 |
| D | ASN103 |
| D | ALA107 |
| D | LEU108 |
| D | GLU109 |
| D | SER110 |
| D | HOH732 |
| site_id | DC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 D 607 |
| Chain | Residue |
| C | HOH718 |
| D | LYS229 |
| D | LYS254 |
| D | HIS261 |
| D | HOH709 |
| D | HOH712 |
| site_id | DC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PO4 D 608 |
| Chain | Residue |
| D | ARG26 |
| D | HIS89 |
| D | PHE90 |
| D | SER91 |
| D | HOH771 |
| D | HOH880 |
| D | HOH1005 |
| D | HOH1056 |
| D | HOH1109 |
| D | HOH1129 |
| site_id | DC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 D 609 |
| Chain | Residue |
| D | ARG200 |
| D | ARG411 |
| D | ARG475 |
| D | TYR506 |
| D | HOH1153 |
| site_id | DC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 D 610 |
| Chain | Residue |
| D | HIS384 |
| D | HIS386 |
| D | HOH818 |
| D | HOH937 |
| D | HOH1155 |
