4FIF
Catalytic domain of human PAK4 with RPKPLVDP peptide
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE ANP A 1000 |
| Chain | Residue |
| A | GLU329 |
| A | GLU396 |
| A | LEU398 |
| A | LEU447 |
| A | ASP458 |
| A | PHE459 |
| A | GLY460 |
| A | PHE461 |
| A | HOH1118 |
| A | HOH1119 |
| A | HOH1125 |
| A | GLY330 |
| A | SER331 |
| A | THR332 |
| A | VAL335 |
| A | ALA348 |
| A | LYS350 |
| A | GLU366 |
| A | MET395 |
| site_id | AC2 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE ANP B 1000 |
| Chain | Residue |
| B | GLU329 |
| B | GLY330 |
| B | SER331 |
| B | THR332 |
| B | VAL335 |
| B | ALA348 |
| B | LYS350 |
| B | GLU366 |
| B | MET395 |
| B | GLU396 |
| B | PHE397 |
| B | LEU398 |
| B | LEU447 |
| B | ASP458 |
| B | PHE459 |
| B | GLY460 |
| B | PHE461 |
| B | HOH1118 |
| B | HOH1119 |
| B | HOH1130 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR CHAIN C OF SERINE/THREONINE-PROTEIN KINASE PAK 4 |
| Chain | Residue |
| A | SER331 |
| A | GLN358 |
| A | ARG359 |
| A | THR404 |
| A | SER443 |
| A | ASP444 |
| A | PHE461 |
| A | LEU475 |
| A | VAL476 |
| A | GLY477 |
| A | TYR480 |
| A | TRP481 |
| A | GLU507 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR CHAIN D OF SERINE/THREONINE-PROTEIN KINASE PAK 4 |
| Chain | Residue |
| B | SER331 |
| B | ARG359 |
| B | THR404 |
| B | ASP444 |
| B | LEU475 |
| B | VAL476 |
| B | GLY477 |
| B | PRO479 |
| B | TYR480 |
| B | TRP481 |
| B | GLU507 |
| B | PHE516 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 25 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGEGSTGIVCiAtvrssgklv.........AVKK |
| Chain | Residue | Details |
| A | ILE327-LYS351 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 50 |
| Details | Region: {"description":"GEF-interaction domain (GID)"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26607847","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4XBR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XBU","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26607847","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4XBR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XBU","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by autocatalysis","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2005","submissionDatabase":"PDB data bank","title":"Crystal structure of the human p21-activated kinase 4.","authors":["Eswaran J.","Debreczeni J.E.","Bunkoczi G.","Filippakopoulos P.","Das S.","Fedorov O.","Sundstrom M.","Arrowsmith C.","Edwards A.","von Delft F.","Knapp S."]}},{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
