4FIE
Full-length human PAK4
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004674 | molecular_function | protein serine/threonine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004674 | molecular_function | protein serine/threonine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE ANP A 1001 |
| Chain | Residue |
| A | GLY328 |
| A | MET395 |
| A | GLU396 |
| A | LEU398 |
| A | ALA402 |
| A | ASP440 |
| A | LEU447 |
| A | ASP458 |
| A | GLY460 |
| A | PHE461 |
| A | GLU329 |
| A | GLY330 |
| A | SER331 |
| A | THR332 |
| A | VAL335 |
| A | ALA348 |
| A | LYS350 |
| A | GLU366 |
| site_id | AC2 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE ANP B 1001 |
| Chain | Residue |
| B | GLU329 |
| B | GLY330 |
| B | SER331 |
| B | THR332 |
| B | VAL335 |
| B | ALA348 |
| B | LYS350 |
| B | GLU366 |
| B | MET395 |
| B | GLU396 |
| B | PHE397 |
| B | LEU398 |
| B | ALA402 |
| B | ASP440 |
| B | LEU447 |
| B | ASP458 |
| B | GLY460 |
| B | PHE461 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 25 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGEGSTGIVCiAtvrssgklv.........AVKK |
| Chain | Residue | Details |
| A | ILE327-LYS351 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159 |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:26607847, ECO:0007744|PDB:4XBR, ECO:0007744|PDB:4XBU |
| Chain | Residue | Details |
| A | TYR492 | |
| A | TYR515 | |
| B | TYR492 | |
| B | TYR515 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26607847, ECO:0007744|PDB:4XBR, ECO:0007744|PDB:4XBU |
| Chain | Residue | Details |
| A | ALA561 | |
| B | ALA561 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER41 | |
| B | SER41 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-methyllysine => ECO:0007744|PubMed:24129315 |
| Chain | Residue | Details |
| A | LYS243 | |
| B | LYS243 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 10 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195 |
| Chain | Residue | Details |
| A | SER269 | |
| B | LEU456 | |
| A | ASP313 | |
| A | THR332 | |
| A | ALA423 | |
| A | LEU456 | |
| B | SER269 | |
| B | ASP313 | |
| B | THR332 | |
| B | ALA423 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | LEU346 | |
| B | LEU346 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19369195 |
| Chain | Residue | Details |
| A | MET352 | |
| B | MET352 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19369195 |
| Chain | Residue | Details |
| A | ARG360 | |
| B | ARG360 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | ASP372 | |
| B | ASP372 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976 |
| Chain | Residue | Details |
| A | HIS432 | |
| B | HIS432 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by autocatalysis => ECO:0000269|Ref.32, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
