4FHX
Crystal structures of the Cid1 poly (U) polymerase reveal the mechanism for UTP selectivity - H336N mutant bound to MgATP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016779 | molecular_function | nucleotidyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE ATP A 401 |
| Chain | Residue |
| A | PHE88 |
| A | SER211 |
| A | ASN336 |
| A | VAL338 |
| A | ARG340 |
| A | MG402 |
| A | HOH506 |
| A | HOH507 |
| A | HOH539 |
| A | GLY89 |
| A | SER90 |
| A | ASP101 |
| A | ASP103 |
| A | ALA168 |
| A | ASN171 |
| A | THR172 |
| A | LYS193 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 402 |
| Chain | Residue |
| A | ASP101 |
| A | ASP103 |
| A | ATP401 |
| A | HOH539 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22608966, ECO:0000269|PubMed:22751018, ECO:0000269|PubMed:22885303, ECO:0000269|PubMed:24322298, ECO:0007744|PDB:4E80, ECO:0007744|PDB:4EP7, ECO:0007744|PDB:4FH5, ECO:0007744|PDB:4FHP, ECO:0007744|PDB:4FHW, ECO:0007744|PDB:4FHX, ECO:0007744|PDB:4NKT |
| Chain | Residue | Details |
| A | SER90 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22608966, ECO:0000269|PubMed:22885303, ECO:0007744|PDB:4EP7, ECO:0007744|PDB:4FH5, ECO:0007744|PDB:4FHP, ECO:0007744|PDB:4FHW, ECO:0007744|PDB:4FHX, ECO:0007744|PDB:4FHY |
| Chain | Residue | Details |
| A | ASP101 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22608966, ECO:0000269|PubMed:22885303, ECO:0007744|PDB:4EP7, ECO:0007744|PDB:4FH5, ECO:0007744|PDB:4FHP, ECO:0007744|PDB:4FHV, ECO:0007744|PDB:4FHW, ECO:0007744|PDB:4FHX, ECO:0007744|PDB:4FHY |
| Chain | Residue | Details |
| A | ASP103 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22885303, ECO:0007744|PDB:4FHP, ECO:0007744|PDB:4FHW |
| Chain | Residue | Details |
| A | ALA168 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22608966, ECO:0000269|PubMed:22751018, ECO:0000269|PubMed:22885303, ECO:0000269|PubMed:24322298, ECO:0007744|PDB:4E80, ECO:0007744|PDB:4EP7, ECO:0007744|PDB:4FH5, ECO:0007744|PDB:4FHP, ECO:0007744|PDB:4FHV, ECO:0007744|PDB:4FHX, ECO:0007744|PDB:4NKT, ECO:0007744|PDB:4NKU |
| Chain | Residue | Details |
| A | ASN171 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22608966, ECO:0000269|PubMed:22885303, ECO:0000269|PubMed:24322298, ECO:0007744|PDB:4EP7, ECO:0007744|PDB:4FHP, ECO:0007744|PDB:4NKT, ECO:0007744|PDB:4NKU |
| Chain | Residue | Details |
| A | THR172 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22608966, ECO:0000269|PubMed:22751018, ECO:0000269|PubMed:22885303, ECO:0000269|PubMed:24322298, ECO:0007744|PDB:4E80, ECO:0007744|PDB:4EP7, ECO:0007744|PDB:4FH5, ECO:0007744|PDB:4FHP, ECO:0007744|PDB:4FHV, ECO:0007744|PDB:4FHW, ECO:0007744|PDB:4FHX, ECO:0007744|PDB:4NKT |
| Chain | Residue | Details |
| A | LYS193 | |
| A | SER211 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22608966, ECO:0000269|PubMed:22751018, ECO:0000269|PubMed:22885303, ECO:0000269|PubMed:24322298, ECO:0007744|PDB:4E80, ECO:0007744|PDB:4EP7, ECO:0007744|PDB:4FH5, ECO:0007744|PDB:4FHP, ECO:0007744|PDB:4FHV, ECO:0007744|PDB:4FHW, ECO:0007744|PDB:4NKT |
| Chain | Residue | Details |
| A | LYS197 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22608966, ECO:0000269|PubMed:22751018, ECO:0000269|PubMed:22885303, ECO:0000269|PubMed:24322298, ECO:0007744|PDB:4E80, ECO:0007744|PDB:4EP7, ECO:0007744|PDB:4FH5, ECO:0007744|PDB:4FHP, ECO:0007744|PDB:4FHV, ECO:0007744|PDB:4FHW, ECO:0007744|PDB:4NKT, ECO:0007744|PDB:4NKU |
| Chain | Residue | Details |
| A | TYR212 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22608966, ECO:0000269|PubMed:22885303, ECO:0000269|PubMed:24322298, ECO:0007744|PDB:4EP7, ECO:0007744|PDB:4FH5, ECO:0007744|PDB:4FHP, ECO:0007744|PDB:4FHV, ECO:0007744|PDB:4FHW, ECO:0007744|PDB:4NKT, ECO:0007744|PDB:4NKU |
| Chain | Residue | Details |
| A | ASN336 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22885303, ECO:0007744|PDB:4FHX |
| Chain | Residue | Details |
| A | ARG340 |
