4FFL

PylC in complex with L-lysine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0005829	cellular_component	cytosol
A	0008652	biological_process	amino acid biosynthetic process
A	0016874	molecular_function	ligase activity
A	0046872	molecular_function	metal ion binding
A	0071524	biological_process	pyrrolysine biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE LYS A 901

Chain	Residue
A	LYS10
A	HOH1001
A	HOH1038
A	HOH1069
A	LEU11
A	GLN12
A	GLU72
A	SER137
A	SER246
A	GLU302
A	PO4903
A	ATP908

---

site_id	AC2
Number of Residues	26
Details	BINDING SITE FOR RESIDUE ADP A 902

Chain	Residue
A	LYS104
A	PHE129
A	LYS131
A	GLU135
A	SER136
A	SER137
A	SER138
A	GLU160
A	GLU161
A	TYR162
A	VAL163
A	VAL167
A	ILE189
A	GLU227
A	ILE229
A	ILE238
A	GLU239
A	PO4903
A	MG904
A	MG905
A	HOH1011
A	HOH1018
A	HOH1019
A	HOH1029
A	HOH1281
A	HOH1283

---

site_id	AC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE PO4 A 903

Chain	Residue
A	SER136
A	SER137
A	GLU227
A	GLU239
A	ASP241
A	ARG243
A	LYS901
A	ADP902
A	MG904
A	MG905
A	MG906
A	CO3907
A	HOH1087
A	HOH1270
A	HOH1283

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 904

Chain	Residue
A	GLU227
A	GLU239
A	ADP902
A	PO4903
A	MG905
A	HOH1283

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 905

Chain	Residue
A	GLU239
A	ASP241
A	ADP902
A	PO4903
A	MG904
A	HOH1281

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 906

Chain	Residue
A	GLU227
A	PO4903
A	CO3907
A	HOH1243
A	HOH1270

---

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CO3 A 907

Chain	Residue
A	VAL187
A	GLU227
A	SER246
A	GLN247
A	PO4903
A	MG906
A	HOH1069
A	HOH1087
A	HOH1243

---

site_id	AC8
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ATP A 908

Chain	Residue
A	GLY8
A	LYS10
A	ASP31
A	LYS32
A	PHE48
A	ASP49
A	VAL50
A	ILE51
A	ASN71
A	GLU72
A	ASN73
A	CYS76
A	LYS901
A	HOH1036
A	HOH1038
A	HOH1103
A	HOH1189

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:22985965, ECO:0007744|PDB:4FFL, ECO:0007744|PDB:4FFM, ECO:0007744|PDB:4FFN, ECO:0007744|PDB:4FFO, ECO:0007744|PDB:4FFR

Chain	Residue	Details
A	LYS10
A	ASP31
A	ASP49

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:22985965, ECO:0007744|PDB:4FFL

Chain	Residue	Details
A	LEU11
A	GLU72
A	SER246
A	GLU302

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:22985965, ECO:0007744|PDB:4FFL, ECO:0007744|PDB:4FFM, ECO:0007744|PDB:4FFO, ECO:0007744|PDB:4FFP

Chain	Residue	Details
A	LYS104
A	LYS131
A	GLU160

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:22985965, ECO:0007744|PDB:4FFL, ECO:0007744|PDB:4FFO, ECO:0007744|PDB:4FFP

Chain	Residue	Details
A	SER138

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:22985965, ECO:0007744|PDB:4FFN

Chain	Residue	Details
A	SER169
A	ASP225
A	ARG243

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:22985965, ECO:0007744|PDB:4FFL, ECO:0007744|PDB:4FFM, ECO:0007744|PDB:4FFN, ECO:0007744|PDB:4FFO, ECO:0007744|PDB:4FFP, ECO:0007744|PDB:4FFR

Chain	Residue	Details
A	GLU227
A	GLU239
A	ASP241

---