Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004807 | molecular_function | triose-phosphate isomerase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006094 | biological_process | gluconeogenesis |
| A | 0006096 | biological_process | glycolytic process |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0019563 | biological_process | glycerol catabolic process |
| A | 0046166 | biological_process | glyceraldehyde-3-phosphate biosynthetic process |
| B | 0004807 | molecular_function | triose-phosphate isomerase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006094 | biological_process | gluconeogenesis |
| B | 0006096 | biological_process | glycolytic process |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0019563 | biological_process | glycerol catabolic process |
| B | 0046166 | biological_process | glyceraldehyde-3-phosphate biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE PGA A 301 |
| Chain | Residue |
| A | LYS12 |
| A | GLY233 |
| A | NA308 |
| A | HOH421 |
| A | HOH456 |
| A | HOH537 |
| A | HIS95 |
| A | GLU165 |
| A | ALA169 |
| A | ILE170 |
| A | GLY171 |
| A | SER211 |
| A | LEU230 |
| A | GLY232 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 302 |
| Chain | Residue |
| A | ASP48 |
| A | TYR49 |
| A | HOH428 |
| A | HOH472 |
| A | HOH501 |
| B | LYS17 |
| B | ASP48 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 303 |
| Chain | Residue |
| A | GLU153 |
| A | VAL154 |
| A | LYS155 |
| A | ASP156 |
| A | HOH466 |
| B | GLY197 |
| B | ASP198 |
| B | LYS199 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 304 |
| Chain | Residue |
| A | LYS69 |
| A | ALA70 |
| A | SER71 |
| A | LYS135 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 305 |
| Chain | Residue |
| A | TYR101 |
| A | PHE102 |
| A | HIS103 |
| B | PHE102 |
| B | HIS103 |
| B | PHE108 |
| B | LYS135 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 306 |
| Chain | Residue |
| A | ALA2 |
| A | ARG26 |
| A | PRO238 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL A 307 |
| Chain | Residue |
| A | GLY122 |
| A | ASN159 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA A 308 |
| Chain | Residue |
| A | ASN10 |
| A | HIS95 |
| A | GLU165 |
| A | LEU230 |
| A | PGA301 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 301 |
| Chain | Residue |
| B | SER211 |
| B | GLY232 |
| B | GLY233 |
| B | GOL303 |
| B | HOH450 |
| B | HOH454 |
| B | HOH497 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 302 |
| Chain | Residue |
| A | SER31 |
| A | HOH487 |
| B | SER31 |
| B | HOH552 |
| site_id | BC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL B 303 |
| Chain | Residue |
| B | ASN10 |
| B | LYS12 |
| B | HIS95 |
| B | GLU165 |
| B | GLY209 |
| B | LEU230 |
| B | GLY232 |
| B | SO4301 |
| B | HOH494 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 304 |
| Chain | Residue |
| A | HIS103 |
| A | HOH538 |
| B | TYR101 |
| B | HIS103 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 305 |
| Chain | Residue |
| B | VAL54 |
| B | LYS55 |
| B | LYS56 |
| B | PRO57 |
| B | GOL306 |
| B | HOH462 |
| site_id | BC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 306 |
| Chain | Residue |
| A | VAL54 |
| A | LYS55 |
| A | LYS56 |
| A | PRO57 |
| B | LYS55 |
| B | PRO57 |
| B | GOL305 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 307 |
| Chain | Residue |
| A | PRO57 |
| B | GLU25 |
| B | ASN28 |
| B | THR29 |
| B | LYS55 |
| B | HOH526 |
| site_id | BC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL B 308 |
| Chain | Residue |
| B | SER96 |
| B | SER100 |
| B | HOH529 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 B 309 |
| Chain | Residue |
| B | HOH506 |
| B | LYS89 |
| B | TRP90 |
| B | ASN159 |
| site_id | BC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 B 310 |
| Chain | Residue |
| B | LYS69 |
| B | ALA70 |
| B | SER71 |
| B | PHE115 |
| site_id | CC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 B 311 |
| Chain | Residue |
| B | PRO33 |
| B | GLU34 |
| B | ASN35 |
| B | VAL36 |
| B | HOH486 |
Functional Information from PROSITE/UniProt
| site_id | PS00171 |
| Number of Residues | 11 |
| Details | TIM_1 Triosephosphate isomerase active site. AYEPVWAIGTG |
| Chain | Residue | Details |
| A | ALA163-GLY173 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Electrophile |
| Chain | Residue | Details |
| A | HIS95 | |
| B | HIS95 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor |
| Chain | Residue | Details |
| A | GLU165 | |
| B | GLU165 | |
| Chain | Residue | Details |
| A | ASN10 | |
| A | LYS12 | |
| B | ASN10 | |
| B | LYS12 | |
| Chain | Residue | Details |
| A | THR4 | |
| B | THR4 | |
| Chain | Residue | Details |
| A | SER71 | |
| A | SER215 | |
| B | SER71 | |
| B | SER215 | |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047 |
| Chain | Residue | Details |
| A | LYS223 | |
| B | LYS223 | |
