4FF5

Structure basis of a novel virulence factor GHIP a glycosyl hydrolase 25 of Streptococcus pneumoniae participating in host cell invasion

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003796	molecular_function	lysozyme activity
A	0009253	biological_process	peptidoglycan catabolic process
A	0016020	cellular_component	membrane
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0016998	biological_process	cell wall macromolecule catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO A 301

Chain	Residue
A	MET137
A	SER138
A	ASN139
A	GLU142
A	HOH589
A	HOH611
A	HOH631
A	HOH652

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO A 302

Chain	Residue
A	LYS79
A	SER195
A	SER196
A	HOH413
A	HOH595
A	HOH653
A	HOH656
A	GLU68

---

site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE EDO A 303

Chain	Residue
A	ASP70

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site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 304

Chain	Residue
A	SER61
A	GLY62
A	THR65
A	ILE74

---

site_id	AC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE EDO A 305

Chain	Residue
A	GLU20
A	TYR166
A	ARG237
A	LEU241
A	LYS242
A	EDO306
A	EDO307
A	HOH628
A	HOH641

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 306

Chain	Residue
A	TYR166
A	GLU170
A	LYS242
A	EDO305
A	HOH501

---

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE EDO A 307

Chain	Residue
A	GLU20
A	TYR166
A	ARG237
A	LEU241
A	EDO305
A	HOH555
A	HOH597
A	HOH640
A	HOH641

---