4FES
Structure of OSH4 in complex with cholesterol analogs
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000139 | cellular_component | Golgi membrane |
| A | 0005546 | molecular_function | phosphatidylinositol-4,5-bisphosphate binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005829 | cellular_component | cytosol |
| A | 0006665 | biological_process | sphingolipid metabolic process |
| A | 0006869 | biological_process | lipid transport |
| A | 0006887 | biological_process | exocytosis |
| A | 0006892 | biological_process | post-Golgi vesicle-mediated transport |
| A | 0006897 | biological_process | endocytosis |
| A | 0008142 | molecular_function | oxysterol binding |
| A | 0008289 | molecular_function | lipid binding |
| A | 0015248 | molecular_function | obsolete sterol transporter activity |
| A | 0015918 | biological_process | sterol transport |
| A | 0016020 | cellular_component | membrane |
| A | 0030011 | biological_process | maintenance of cell polarity |
| A | 0034727 | biological_process | piecemeal microautophagy of the nucleus |
| A | 0035621 | biological_process | ER to Golgi ceramide transport |
| A | 0070273 | molecular_function | phosphatidylinositol-4-phosphate binding |
| A | 0070300 | molecular_function | phosphatidic acid binding |
| A | 0120015 | molecular_function | sterol transfer activity |
| B | 0000139 | cellular_component | Golgi membrane |
| B | 0005546 | molecular_function | phosphatidylinositol-4,5-bisphosphate binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005794 | cellular_component | Golgi apparatus |
| B | 0005829 | cellular_component | cytosol |
| B | 0006665 | biological_process | sphingolipid metabolic process |
| B | 0006869 | biological_process | lipid transport |
| B | 0006887 | biological_process | exocytosis |
| B | 0006892 | biological_process | post-Golgi vesicle-mediated transport |
| B | 0006897 | biological_process | endocytosis |
| B | 0008142 | molecular_function | oxysterol binding |
| B | 0008289 | molecular_function | lipid binding |
| B | 0015248 | molecular_function | obsolete sterol transporter activity |
| B | 0015918 | biological_process | sterol transport |
| B | 0016020 | cellular_component | membrane |
| B | 0030011 | biological_process | maintenance of cell polarity |
| B | 0034727 | biological_process | piecemeal microautophagy of the nucleus |
| B | 0035621 | biological_process | ER to Golgi ceramide transport |
| B | 0070273 | molecular_function | phosphatidylinositol-4-phosphate binding |
| B | 0070300 | molecular_function | phosphatidic acid binding |
| B | 0120015 | molecular_function | sterol transfer activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 0T9 A 501 |
| Chain | Residue |
| A | PHE13 |
| A | ILE203 |
| A | ILE206 |
| A | HOH662 |
| A | HOH693 |
| A | GLN96 |
| A | TYR97 |
| A | ARG100 |
| A | GLU107 |
| A | LYS109 |
| A | PRO110 |
| A | ASN165 |
| A | GLN181 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 0T9 B 501 |
| Chain | Residue |
| B | PHE13 |
| B | GLN96 |
| B | TYR97 |
| B | ARG100 |
| B | GLU107 |
| B | LYS108 |
| B | LYS109 |
| B | PRO110 |
| B | ASN165 |
| B | GLN181 |
| B | ILE203 |
| B | HOH625 |
| B | HOH655 |
Functional Information from PROSITE/UniProt
| site_id | PS01013 |
| Number of Residues | 11 |
| Details | OSBP Oxysterol-binding protein family signature. EQvSHHPPv.TA |
| Chain | Residue | Details |
| A | GLU139-ALA149 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 44 |
| Details | Region: {"description":"ALPS motif","evidences":[{"source":"PubMed","id":"17220896","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22162133","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3SPW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"1ZHZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"1ZHT","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
