Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0030976 | molecular_function | thiamine pyrophosphate binding |
| A | 0047112 | molecular_function | pyruvate oxidase activity |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0030976 | molecular_function | thiamine pyrophosphate binding |
| B | 0047112 | molecular_function | pyruvate oxidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 35 |
| Details | BINDING SITE FOR RESIDUE FAD A 701 |
| Chain | Residue |
| A | HIS101 |
| A | ARG264 |
| A | VAL265 |
| A | GLY284 |
| A | ASN285 |
| A | ASN286 |
| A | PRO288 |
| A | PHE289 |
| A | ASP306 |
| A | ILE307 |
| A | ASP308 |
| A | PHE121 |
| A | LYS311 |
| A | ALA324 |
| A | ASP325 |
| A | ALA326 |
| A | ASN398 |
| A | SER416 |
| A | ASN417 |
| A | PYR704 |
| A | TDM708 |
| A | HOH8003 |
| A | GLY220 |
| A | HOH8015 |
| A | HOH8037 |
| A | HOH8063 |
| A | HOH8371 |
| A | HOH8455 |
| A | HOH8615 |
| A | ILE221 |
| A | GLY222 |
| A | THR244 |
| A | TYR245 |
| A | ALA262 |
| A | ASN263 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 702 |
| Chain | Residue |
| A | ALA23 |
| A | TRP24 |
| A | LYS75 |
| A | TYR158 |
| A | TYR189 |
| A | HOH8632 |
| B | HOH1427 |
| B | HOH1444 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PYR A 703 |
| Chain | Residue |
| A | LEU555 |
| A | ARG556 |
| A | LEU557 |
| A | ASP558 |
| A | MET561 |
| A | SER562 |
| A | HOH8159 |
| A | HOH8235 |
| A | HOH8608 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PYR A 704 |
| Chain | Residue |
| A | PHE121 |
| A | ASN263 |
| A | ARG264 |
| A | FAD701 |
| A | HOH8819 |
| A | HOH8821 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 705 |
| Chain | Residue |
| A | LYS433 |
| A | PRO437 |
| A | GLU438 |
| A | PRO466 |
| A | ALA533 |
| A | GLN534 |
| A | HOH8197 |
| A | HOH8212 |
| A | HOH8480 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 706 |
| Chain | Residue |
| A | TRP174 |
| A | THR487 |
| A | GLN489 |
| A | HOH8574 |
| site_id | AC7 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE PO4 A 707 |
| Chain | Residue |
| A | GLY34 |
| A | GLY35 |
| A | SER36 |
| A | SER82 |
| A | PHE111 |
| A | GLN122 |
| A | ILE480 |
| A | TDM708 |
| A | HOH8221 |
| A | HOH8284 |
| A | HOH8813 |
| site_id | AC8 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE TDM A 708 |
| Chain | Residue |
| A | GLY478 |
| A | PHE479 |
| A | ILE480 |
| A | FAD701 |
| A | PO4707 |
| A | MG710 |
| A | HOH8052 |
| A | HOH8073 |
| A | HOH8082 |
| A | HOH8115 |
| A | PRO33 |
| A | GLU59 |
| A | SER82 |
| A | PRO85 |
| A | HIS89 |
| A | GLN122 |
| A | VAL394 |
| A | ASP396 |
| A | ALA420 |
| A | MET422 |
| A | GLY446 |
| A | ASP447 |
| A | GLY448 |
| A | GLY449 |
| A | ASN474 |
| A | GLN476 |
| A | TYR477 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 709 |
| Chain | Residue |
| A | ARG224 |
| A | PRO409 |
| A | HOH8127 |
| A | HOH8189 |
| A | HOH8271 |
| A | HOH8741 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 710 |
| Chain | Residue |
| A | ASP447 |
| A | ASN474 |
| A | GLN476 |
| A | TDM708 |
| A | HOH8082 |
| site_id | BC2 |
| Number of Residues | 35 |
| Details | BINDING SITE FOR RESIDUE FAD B 701 |
| Chain | Residue |
| B | HIS101 |
| B | PHE121 |
| B | GLY220 |
| B | ILE221 |
| B | GLY222 |
| B | THR244 |
| B | TYR245 |
| B | ALA262 |
| B | ASN263 |
| B | ARG264 |
| B | VAL265 |
| B | GLY284 |
| B | ASN285 |
| B | ASN286 |
| B | PRO288 |
| B | PHE289 |
| B | ASP306 |
| B | ILE307 |
| B | ASP308 |
| B | LYS311 |
| B | ALA324 |
| B | ASP325 |
| B | ALA326 |
| B | ASN398 |
| B | SER416 |
| B | ASN417 |
| B | PYR703 |
| B | TDM704 |
| B | HOH811 |
| B | HOH821 |
| B | HOH837 |
| B | HOH858 |
| B | HOH1110 |
| B | HOH1158 |
| B | HOH1524 |
| site_id | BC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PYR B 702 |
| Chain | Residue |
| B | LEU555 |
| B | ARG556 |
| B | LEU557 |
| B | ASP558 |
| B | MET561 |
| B | SER562 |
| B | HOH1126 |
| B | HOH1192 |
| B | HOH1262 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PYR B 703 |
| Chain | Residue |
| B | PHE121 |
| B | ASN263 |
| B | ARG264 |
| B | FAD701 |
| B | HOH1275 |
| site_id | BC5 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE TDM B 704 |
| Chain | Residue |
| B | PRO33 |
| B | GLU59 |
| B | SER82 |
| B | PRO85 |
| B | HIS89 |
| B | GLN122 |
| B | VAL394 |
| B | ASP396 |
| B | ALA420 |
| B | MET422 |
| B | GLY446 |
| B | ASP447 |
| B | GLY448 |
| B | GLY449 |
| B | ASN474 |
| B | GLN476 |
| B | TYR477 |
| B | GLY478 |
| B | PHE479 |
| B | ILE480 |
| B | FAD701 |
| B | PO4705 |
| B | MG708 |
| B | HOH820 |
| B | HOH929 |
| B | HOH940 |
| B | HOH1335 |
| site_id | BC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PO4 B 705 |
| Chain | Residue |
| B | GLY34 |
| B | GLY35 |
| B | SER36 |
| B | SER82 |
| B | PHE111 |
| B | GLN122 |
| B | ILE480 |
| B | TDM704 |
| B | HOH928 |
| B | HOH950 |
| site_id | BC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 706 |
| Chain | Residue |
| A | HOH8219 |
| B | ALA569 |
| B | PHE570 |
| B | ARG573 |
| B | TYR574 |
| B | HOH907 |
| B | HOH996 |
| site_id | BC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 707 |
| Chain | Residue |
| B | ARG224 |
| B | PRO409 |
| B | ARG412 |
| B | HOH943 |
| B | HOH1089 |
| B | HOH1402 |
| site_id | BC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 708 |
| Chain | Residue |
| B | ASP447 |
| B | ASN474 |
| B | GLN476 |
| B | TDM704 |
| B | HOH940 |
Functional Information from PROSITE/UniProt
| site_id | PS00187 |
| Number of Residues | 20 |
| Details | TPP_ENZYMES Thiamine pyrophosphate enzymes signature. IAaklnyPerqvFnLaGDGG |
| Chain | Residue | Details |
| A | ILE430-GLY449 | |
