4FC2
Crystal structure of mouse poly(ADP-ribose) glycohydrolase (PARG) catalytic domain
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004649 | molecular_function | poly(ADP-ribose) glycohydrolase activity |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006282 | biological_process | regulation of DNA repair |
| B | 0004649 | molecular_function | poly(ADP-ribose) glycohydrolase activity |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0006282 | biological_process | regulation of DNA repair |
| C | 0004649 | molecular_function | poly(ADP-ribose) glycohydrolase activity |
| C | 0005975 | biological_process | carbohydrate metabolic process |
| C | 0006282 | biological_process | regulation of DNA repair |
| D | 0004649 | molecular_function | poly(ADP-ribose) glycohydrolase activity |
| D | 0005975 | biological_process | carbohydrate metabolic process |
| D | 0006282 | biological_process | regulation of DNA repair |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1001 |
| Chain | Residue |
| A | PRO465 |
| A | SER466 |
| A | ARG468 |
| A | HOH1274 |
| A | HOH1327 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1002 |
| Chain | Residue |
| A | ASN639 |
| A | ARG528 |
| A | TYR557 |
| A | PRO636 |
| A | ARG637 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1003 |
| Chain | Residue |
| A | ARG656 |
| A | GLY739 |
| A | ALA743 |
| A | GLY744 |
| C | HIS951 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1004 |
| Chain | Residue |
| A | ASN733 |
| A | ARG734 |
| A | HOH1117 |
| A | HOH1260 |
| A | HOH1346 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1005 |
| Chain | Residue |
| A | ARG824 |
| C | LYS444 |
| C | ARG902 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1006 |
| Chain | Residue |
| A | ARG637 |
| A | LYS643 |
| A | SER644 |
| A | GLU645 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1007 |
| Chain | Residue |
| A | ARG724 |
| A | HIS798 |
| A | ASP800 |
| A | GLY801 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1001 |
| Chain | Residue |
| B | PRO465 |
| B | SER466 |
| B | ARG468 |
| B | HOH1291 |
| C | ARG468 |
| C | HOH1264 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1002 |
| Chain | Residue |
| B | ARG528 |
| B | PRO636 |
| B | ARG637 |
| B | ASN639 |
| B | HOH1239 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1003 |
| Chain | Residue |
| B | ARG656 |
| B | GLY739 |
| B | GLY742 |
| B | ALA743 |
| B | GLY744 |
| D | HIS951 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1004 |
| Chain | Residue |
| B | ASN733 |
| B | ARG734 |
| B | HIS821 |
| B | HOH1161 |
| B | HOH1170 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1005 |
| Chain | Residue |
| B | ARG824 |
| D | LYS444 |
| D | ARG902 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1006 |
| Chain | Residue |
| B | ARG637 |
| B | LYS643 |
| B | SER644 |
| B | GLU645 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1007 |
| Chain | Residue |
| B | ARG724 |
| B | HIS798 |
| B | ASP800 |
| B | GLY801 |
| site_id | BC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1001 |
| Chain | Residue |
| C | SER466 |
| C | ARG468 |
| C | HOH1393 |
| site_id | BC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1002 |
| Chain | Residue |
| C | ARG528 |
| C | PRO636 |
| C | ARG637 |
| C | ASN639 |
| C | HOH1236 |
| C | HOH1326 |
| site_id | BC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1003 |
| Chain | Residue |
| A | HIS951 |
| C | ARG656 |
| C | GLY742 |
| C | ALA743 |
| C | GLY744 |
| site_id | BC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1004 |
| Chain | Residue |
| C | ASN733 |
| C | ARG734 |
| C | HIS821 |
| C | HOH1141 |
| C | HOH1277 |
| site_id | CC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1005 |
| Chain | Residue |
| A | LYS444 |
| A | ARG902 |
| A | HOH1351 |
| C | ARG824 |
| C | HOH1330 |
| site_id | CC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1006 |
| Chain | Residue |
| C | ARG637 |
| C | SER644 |
| C | GLU645 |
| C | HOH1446 |
| site_id | CC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1007 |
| Chain | Residue |
| C | ARG724 |
| C | HIS798 |
| C | GLU799 |
| C | ASP800 |
| C | GLY801 |
| site_id | CC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1001 |
| Chain | Residue |
| D | HOH1353 |
| D | SER466 |
| D | ARG468 |
| site_id | CC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1002 |
| Chain | Residue |
| D | ARG528 |
| D | TYR557 |
| D | PRO636 |
| D | ARG637 |
| D | ASN639 |
| D | HOH1173 |
| D | HOH1246 |
| site_id | CC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1003 |
| Chain | Residue |
| B | HIS951 |
| D | ARG656 |
| D | GLY739 |
| D | ALA743 |
| D | GLY744 |
| site_id | CC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1004 |
| Chain | Residue |
| D | ASN733 |
| D | ARG734 |
| D | HIS821 |
| D | HOH1126 |
| D | HOH1238 |
| site_id | CC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1005 |
| Chain | Residue |
| B | LYS444 |
| B | ARG902 |
| D | ARG824 |
| D | HOH1307 |
| site_id | CC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1006 |
| Chain | Residue |
| D | ARG637 |
| D | LYS643 |
| D | SER644 |
| D | GLU645 |
| D | HOH1317 |
| site_id | DC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1007 |
| Chain | Residue |
| D | ARG724 |
| D | HIS798 |
| D | ASP800 |
| D | GLY801 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | ACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:Q86W56 |
| Chain | Residue | Details |
| A | ASP730 | |
| A | GLU748 | |
| A | GLU749 | |
| B | ASP730 | |
| B | GLU748 | |
| B | GLU749 | |
| C | ASP730 | |
| C | GLU748 | |
| C | GLU749 | |
| D | ASP730 | |
| D | GLU748 | |
| D | GLU749 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q86W56 |
| Chain | Residue | Details |
| B | ILE719 | |
| B | ASN733 | |
| B | GLN747 | |
| B | ASN862 | |
| C | ILE719 | |
| C | ASN733 | |
| C | GLN747 | |
| C | ASN862 | |
| D | ILE719 | |
| D | ASN733 | |
| D | GLN747 | |
| D | ASN862 | |
| A | ASN733 | |
| A | GLN747 | |
| A | ASN862 | |
| A | ILE719 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q9QYM2 |
| Chain | Residue | Details |
| A | TYR788 | |
| B | TYR788 | |
| C | TYR788 | |
| D | TYR788 |
