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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4FC2

Crystal structure of mouse poly(ADP-ribose) glycohydrolase (PARG) catalytic domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004649	molecular_function	poly(ADP-ribose) glycohydrolase activity
A	0005975	biological_process	carbohydrate metabolic process
A	0006282	biological_process	regulation of DNA repair
B	0004649	molecular_function	poly(ADP-ribose) glycohydrolase activity
B	0005975	biological_process	carbohydrate metabolic process
B	0006282	biological_process	regulation of DNA repair
C	0004649	molecular_function	poly(ADP-ribose) glycohydrolase activity
C	0005975	biological_process	carbohydrate metabolic process
C	0006282	biological_process	regulation of DNA repair
D	0004649	molecular_function	poly(ADP-ribose) glycohydrolase activity
D	0005975	biological_process	carbohydrate metabolic process
D	0006282	biological_process	regulation of DNA repair

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 1001

Chain	Residue
A	PRO465
A	SER466
A	ARG468
A	HOH1274
A	HOH1327

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 1002

Chain	Residue
A	ASN639
A	ARG528
A	TYR557
A	PRO636
A	ARG637

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 1003

Chain	Residue
A	ARG656
A	GLY739
A	ALA743
A	GLY744
C	HIS951

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 1004

Chain	Residue
A	ASN733
A	ARG734
A	HOH1117
A	HOH1260
A	HOH1346

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 1005

Chain	Residue
A	ARG824
C	LYS444
C	ARG902

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 1006

Chain	Residue
A	ARG637
A	LYS643
A	SER644
A	GLU645

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 1007

Chain	Residue
A	ARG724
A	HIS798
A	ASP800
A	GLY801

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 1001

Chain	Residue
B	PRO465
B	SER466
B	ARG468
B	HOH1291
C	ARG468
C	HOH1264

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 1002

Chain	Residue
B	ARG528
B	PRO636
B	ARG637
B	ASN639
B	HOH1239

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 1003

Chain	Residue
B	ARG656
B	GLY739
B	GLY742
B	ALA743
B	GLY744
D	HIS951

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 1004

Chain	Residue
B	ASN733
B	ARG734
B	HIS821
B	HOH1161
B	HOH1170

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 1005

Chain	Residue
B	ARG824
D	LYS444
D	ARG902

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 1006

Chain	Residue
B	ARG637
B	LYS643
B	SER644
B	GLU645

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 1007

Chain	Residue
B	ARG724
B	HIS798
B	ASP800
B	GLY801

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 1001

Chain	Residue
C	SER466
C	ARG468
C	HOH1393

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 C 1002

Chain	Residue
C	ARG528
C	PRO636
C	ARG637
C	ASN639
C	HOH1236
C	HOH1326

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 C 1003

Chain	Residue
A	HIS951
C	ARG656
C	GLY742
C	ALA743
C	GLY744

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 C 1004

Chain	Residue
C	ASN733
C	ARG734
C	HIS821
C	HOH1141
C	HOH1277

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 C 1005

Chain	Residue
A	LYS444
A	ARG902
A	HOH1351
C	ARG824
C	HOH1330

site_id	CC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 1006

Chain	Residue
C	ARG637
C	SER644
C	GLU645
C	HOH1446

site_id	CC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 C 1007

Chain	Residue
C	ARG724
C	HIS798
C	GLU799
C	ASP800
C	GLY801

site_id	CC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 1001

Chain	Residue
D	HOH1353
D	SER466
D	ARG468

site_id	CC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 D 1002

Chain	Residue
D	ARG528
D	TYR557
D	PRO636
D	ARG637
D	ASN639
D	HOH1173
D	HOH1246

site_id	CC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D 1003

Chain	Residue
B	HIS951
D	ARG656
D	GLY739
D	ALA743
D	GLY744

site_id	CC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D 1004

Chain	Residue
D	ASN733
D	ARG734
D	HIS821
D	HOH1126
D	HOH1238

site_id	CC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 1005

Chain	Residue
B	LYS444
B	ARG902
D	ARG824
D	HOH1307

site_id	CC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D 1006

Chain	Residue
D	ARG637
D	LYS643
D	SER644
D	GLU645
D	HOH1317

site_id	DC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 1007

Chain	Residue
D	ARG724
D	HIS798
D	ASP800
D	GLY801

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Active site: {"evidences":[{"source":"UniProtKB","id":"Q86W56","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q86W56","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9QYM2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

246704

PDB entries from 2025-12-24

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