Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4FBG

Crystal structure of Treponema denticola trans-2-enoyl-CoA reductase in complex with NAD

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0006633	biological_process	fatty acid biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0016628	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
A	0050343	molecular_function	trans-2-enoyl-CoA reductase (NADH) activity
A	0051287	molecular_function	NAD binding
B	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B	0006629	biological_process	lipid metabolic process
B	0006631	biological_process	fatty acid metabolic process
B	0006633	biological_process	fatty acid biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0016628	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
B	0050343	molecular_function	trans-2-enoyl-CoA reductase (NADH) activity
B	0051287	molecular_function	NAD binding
C	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C	0006629	biological_process	lipid metabolic process
C	0006631	biological_process	fatty acid metabolic process
C	0006633	biological_process	fatty acid biosynthetic process
C	0016491	molecular_function	oxidoreductase activity
C	0016628	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
C	0050343	molecular_function	trans-2-enoyl-CoA reductase (NADH) activity
C	0051287	molecular_function	NAD binding
D	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D	0006629	biological_process	lipid metabolic process
D	0006631	biological_process	fatty acid metabolic process
D	0006633	biological_process	fatty acid biosynthetic process
D	0016491	molecular_function	oxidoreductase activity
D	0016628	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
D	0050343	molecular_function	trans-2-enoyl-CoA reductase (NADH) activity
D	0051287	molecular_function	NAD binding
E	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E	0006629	biological_process	lipid metabolic process
E	0006631	biological_process	fatty acid metabolic process
E	0006633	biological_process	fatty acid biosynthetic process
E	0016491	molecular_function	oxidoreductase activity
E	0016628	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
E	0050343	molecular_function	trans-2-enoyl-CoA reductase (NADH) activity
E	0051287	molecular_function	NAD binding
F	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
F	0006629	biological_process	lipid metabolic process
F	0006631	biological_process	fatty acid metabolic process
F	0006633	biological_process	fatty acid biosynthetic process
F	0016491	molecular_function	oxidoreductase activity
F	0016628	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
F	0050343	molecular_function	trans-2-enoyl-CoA reductase (NADH) activity
F	0051287	molecular_function	NAD binding
G	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
G	0006629	biological_process	lipid metabolic process
G	0006631	biological_process	fatty acid metabolic process
G	0006633	biological_process	fatty acid biosynthetic process
G	0016491	molecular_function	oxidoreductase activity
G	0016628	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
G	0050343	molecular_function	trans-2-enoyl-CoA reductase (NADH) activity
G	0051287	molecular_function	NAD binding
H	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H	0006629	biological_process	lipid metabolic process
H	0006631	biological_process	fatty acid metabolic process
H	0006633	biological_process	fatty acid biosynthetic process
H	0016491	molecular_function	oxidoreductase activity
H	0016628	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
H	0050343	molecular_function	trans-2-enoyl-CoA reductase (NADH) activity
H	0051287	molecular_function	NAD binding
I	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I	0006629	biological_process	lipid metabolic process
I	0006631	biological_process	fatty acid metabolic process
I	0006633	biological_process	fatty acid biosynthetic process
I	0016491	molecular_function	oxidoreductase activity
I	0016628	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
I	0050343	molecular_function	trans-2-enoyl-CoA reductase (NADH) activity
I	0051287	molecular_function	NAD binding
J	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
J	0006629	biological_process	lipid metabolic process
J	0006631	biological_process	fatty acid metabolic process
J	0006633	biological_process	fatty acid biosynthetic process
J	0016491	molecular_function	oxidoreductase activity
J	0016628	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
J	0050343	molecular_function	trans-2-enoyl-CoA reductase (NADH) activity
J	0051287	molecular_function	NAD binding
K	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K	0006629	biological_process	lipid metabolic process
K	0006631	biological_process	fatty acid metabolic process
K	0006633	biological_process	fatty acid biosynthetic process
K	0016491	molecular_function	oxidoreductase activity
K	0016628	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
K	0050343	molecular_function	trans-2-enoyl-CoA reductase (NADH) activity
K	0051287	molecular_function	NAD binding
L	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
L	0006629	biological_process	lipid metabolic process
L	0006631	biological_process	fatty acid metabolic process
L	0006633	biological_process	fatty acid biosynthetic process
L	0016491	molecular_function	oxidoreductase activity
L	0016628	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
L	0050343	molecular_function	trans-2-enoyl-CoA reductase (NADH) activity
L	0051287	molecular_function	NAD binding
M	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M	0006629	biological_process	lipid metabolic process
M	0006631	biological_process	fatty acid metabolic process
M	0006633	biological_process	fatty acid biosynthetic process
M	0016491	molecular_function	oxidoreductase activity
M	0016628	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
M	0050343	molecular_function	trans-2-enoyl-CoA reductase (NADH) activity
M	0051287	molecular_function	NAD binding
N	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
N	0006629	biological_process	lipid metabolic process
N	0006631	biological_process	fatty acid metabolic process
N	0006633	biological_process	fatty acid biosynthetic process
N	0016491	molecular_function	oxidoreductase activity
N	0016628	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
N	0050343	molecular_function	trans-2-enoyl-CoA reductase (NADH) activity
N	0051287	molecular_function	NAD binding
O	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
O	0006629	biological_process	lipid metabolic process
O	0006631	biological_process	fatty acid metabolic process
O	0006633	biological_process	fatty acid biosynthetic process
O	0016491	molecular_function	oxidoreductase activity
O	0016628	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
O	0050343	molecular_function	trans-2-enoyl-CoA reductase (NADH) activity
O	0051287	molecular_function	NAD binding
P	0004318	molecular_function	enoyl-[acyl-carrier-protein] reductase (NADH) activity
P	0006629	biological_process	lipid metabolic process
P	0006631	biological_process	fatty acid metabolic process
P	0006633	biological_process	fatty acid biosynthetic process
P	0016491	molecular_function	oxidoreductase activity
P	0016628	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
P	0050343	molecular_function	trans-2-enoyl-CoA reductase (NADH) activity
P	0051287	molecular_function	NAD binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	BINDING SITE FOR RESIDUE NAD A 1001

Chain	Residue
A	GLY53
A	GLY115
A	ASP116
A	ALA117
A	PHE118
A	SER143
A	LEU144
A	ALA145
A	SER146
A	MSE201
A	TYR228
A	SER55
A	SER229
A	LYS274
A	LEU276
A	ASN56
A	GLY57
A	TYR58
A	GLY59
A	SER78
A	PHE79
A	GLU80

site_id	AC2
Number of Residues	24
Details	BINDING SITE FOR RESIDUE NAD E 1001

Chain	Residue
E	GLY53
E	CYS54
E	SER55
E	ASN56
E	GLY57
E	TYR58
E	GLY59
E	SER78
E	PHE79
E	GLU80
E	GLY115
E	ASP116
E	ALA117
E	PHE118
E	SER143
E	LEU144
E	ALA145
E	SER146
E	TYR228
E	SER229
E	TYR230
E	ASN273
E	LYS274
E	LEU276

site_id	AC3
Number of Residues	24
Details	BINDING SITE FOR RESIDUE NAD G 1001

Chain	Residue
G	GLY53
G	CYS54
G	SER55
G	ASN56
G	GLY57
G	TYR58
G	SER78
G	PHE79
G	GLU80
G	GLY115
G	ASP116
G	ALA117
G	PHE118
G	SER143
G	LEU144
G	ALA145
G	SER146
G	TYR228
G	SER229
G	TYR230
G	TYR240
G	LYS274
G	GLY275
G	LEU276

site_id	AC4
Number of Residues	25
Details	BINDING SITE FOR RESIDUE NAD H 1001

Chain	Residue
H	GLY53
H	CYS54
H	SER55
H	ASN56
H	GLY57
H	TYR58
H	GLY59
H	PHE79
H	GLU80
H	GLY115
H	ASP116
H	ALA117
H	PHE118
H	SER143
H	LEU144
H	ALA145
H	SER146
H	MSE201
H	TYR228
H	SER229
H	TYR230
H	ASN273
H	LYS274
H	LEU276
H	THR278

site_id	AC5
Number of Residues	21
Details	BINDING SITE FOR RESIDUE NAD I 1001

Chain	Residue
I	TYR58
I	SER78
I	PHE79
I	GLU80
I	ASP116
I	ALA117
I	PHE118
I	SER143
I	LEU144
I	ALA145
I	SER146
I	TYR228
I	SER229
I	TYR240
I	LYS274
I	LEU276
I	THR278
I	GLY53
I	SER55
I	ASN56
I	GLY57

site_id	AC6
Number of Residues	21
Details	BINDING SITE FOR RESIDUE NAD K 1001

Chain	Residue
K	GLY53
K	CYS54
K	SER55
K	ASN56
K	GLY57
K	TYR58
K	GLY59
K	SER78
K	PHE79
K	GLU80
K	GLY115
K	ASP116
K	ALA117
K	PHE118
K	SER143
K	ALA145
K	SER146
K	TYR230
K	TYR240
K	LYS274
K	THR278

site_id	AC7
Number of Residues	23
Details	BINDING SITE FOR RESIDUE NAD M 1001

Chain	Residue
M	GLY53
M	SER55
M	ASN56
M	GLY57
M	TYR58
M	SER78
M	PHE79
M	GLU80
M	GLY115
M	ASP116
M	ALA117
M	PHE118
M	SER143
M	LEU144
M	ALA145
M	SER146
M	TYR228
M	SER229
M	TYR230
M	ASN273
M	LYS274
M	LEU276
M	THR278

site_id	AC8
Number of Residues	23
Details	BINDING SITE FOR RESIDUE NAD P 1001

Chain	Residue
P	GLY53
P	SER55
P	ASN56
P	GLY57
P	TYR58
P	SER78
P	PHE79
P	GLU80
P	GLY115
P	ASP116
P	ALA117
P	PHE118
P	SER143
P	LEU144
P	ALA145
P	SER146
P	MSE201
P	SER229
P	TYR230
P	ASN273
P	LYS274
P	LEU276
P	THR278

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	Active site: {"description":"Proton donor","evidences":[{"source":"HAMAP-Rule","id":"MF_01838","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"22906002","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"23050861","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	192
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23050861","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	16
Details	Site: {"description":"Plays an important role in discriminating NADH against NADPH","evidences":[{"source":"PubMed","id":"23050861","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)