Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4FA3

Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 in complex with (R)-1-(naphthalen-2-ylsulfonyl)piperidine-3-carboxylic acid (86)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001523	biological_process	retinoid metabolic process
A	0001758	molecular_function	retinal dehydrogenase activity
A	0004032	molecular_function	aldose reductase (NADPH) activity
A	0004033	molecular_function	aldo-keto reductase (NADPH) activity
A	0004303	molecular_function	estradiol 17-beta-dehydrogenase [NAD(P)+] activity
A	0004745	molecular_function	all-trans-retinol dehydrogenase (NAD+) activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006629	biological_process	lipid metabolic process
A	0006693	biological_process	prostaglandin metabolic process
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0007584	biological_process	response to nutrient
A	0008202	biological_process	steroid metabolic process
A	0008284	biological_process	positive regulation of cell population proliferation
A	0008584	biological_process	male gonad development
A	0009267	biological_process	cellular response to starvation
A	0016488	biological_process	farnesol catabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016655	molecular_function	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
A	0019371	biological_process	cyclooxygenase pathway
A	0030216	biological_process	keratinocyte differentiation
A	0032052	molecular_function	bile acid binding
A	0035410	molecular_function	obsolete dihydrotestosterone 17-beta-dehydrogenase activity
A	0036130	molecular_function	prostaglandin H2 endoperoxidase reductase activity
A	0036131	molecular_function	prostaglandin D2 11-ketoreductase activity
A	0042448	biological_process	progesterone metabolic process
A	0042572	biological_process	retinol metabolic process
A	0042574	biological_process	retinal metabolic process
A	0043170	biological_process	macromolecule metabolic process
A	0044597	biological_process	daunorubicin metabolic process
A	0044598	biological_process	doxorubicin metabolic process
A	0045550	molecular_function	geranylgeranyl reductase activity
A	0045703	molecular_function	ketoreductase activity
A	0047017	molecular_function	prostaglandin F synthase activity
A	0047020	molecular_function	15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity
A	0047023	molecular_function	androsterone dehydrogenase activity
A	0047024	molecular_function	5alpha-androstane-3beta,17beta-diol dehydrogenase activity
A	0047035	molecular_function	testosterone dehydrogenase (NAD+) activity
A	0047044	molecular_function	androstan-3-alpha,17-beta-diol dehydrogenase activity
A	0047045	molecular_function	testosterone 17-beta-dehydrogenase (NADP+) activity
A	0047086	molecular_function	ketosteroid monooxygenase activity
A	0047787	molecular_function	Delta4-3-oxosteroid 5beta-reductase activity
A	0048385	biological_process	regulation of retinoic acid receptor signaling pathway
A	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A	0052650	molecular_function	all-trans-retinol dehydrogenase (NADP+) activity
A	0061370	biological_process	testosterone biosynthetic process
A	0070062	cellular_component	extracellular exosome
A	0070293	biological_process	renal absorption
A	0071277	biological_process	cellular response to calcium ion
A	0071379	biological_process	cellular response to prostaglandin stimulus
A	0071384	biological_process	cellular response to corticosteroid stimulus
A	0071395	biological_process	cellular response to jasmonic acid stimulus
A	0071799	biological_process	cellular response to prostaglandin D stimulus
A	1900053	biological_process	negative regulation of retinoic acid biosynthetic process
A	2000224	biological_process	regulation of testosterone biosynthetic process
A	2000353	biological_process	positive regulation of endothelial cell apoptotic process
A	2000379	biological_process	positive regulation of reactive oxygen species metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	29
Details	BINDING SITE FOR RESIDUE NAP A 401

Chain	Residue
A	GLY22
A	TYR216
A	SER217
A	LEU219
A	GLY220
A	SER221
A	GLN222
A	LEU236
A	ALA253
A	LEU268
A	LYS270
A	THR23
A	SER271
A	TYR272
A	ARG276
A	GLN279
A	ASN280
A	0SL402
A	HOH501
A	HOH504
A	HOH530
A	HOH603
A	TYR24
A	ASP50
A	TYR55
A	HIS117
A	SER166
A	ASN167
A	GLN190

site_id	AC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 0SL A 402

Chain	Residue
A	LEU54
A	TYR55
A	TRP86
A	HIS117
A	ASN167
A	TYR216
A	TRP227
A	PHE311
A	NAP401
A	ACT404
A	HOH530

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO A 403

Chain	Residue
A	GLN6
A	PRO17
A	VAL18
A	LEU19
A	GLY45
A	PHE46
A	ARG47
A	PHE284

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT A 404

Chain	Residue
A	SER87
A	SER118
A	MET120
A	PHE311
A	0SL402

Functional Information from PROSITE/UniProt

site_id	PS00062
Number of Residues	18
Details	ALDOKETO_REDUCTASE_2 Aldo/keto reductase family signature 2. MekckdaglAKSIGVSNF

Chain	Residue	Details
A	MET151-PHE168

site_id	PS00063
Number of Residues	16
Details	ALDOKETO_REDUCTASE_3 Aldo/keto reductase family putative active site signature. LAKSYNeqRIrQNvQV

Chain	Residue	Details
A	LEU268-VAL283

site_id	PS00798
Number of Residues	18
Details	ALDOKETO_REDUCTASE_1 Aldo/keto reductase family signature 1. GFRHIDSAhlynnEeqVG

Chain	Residue	Details
A	GLY45-GLY62

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000250

Chain	Residue	Details
A	TYR55

site_id	SWS_FT_FI2
Number of Residues	7
Details	BINDING: BINDING => ECO:0000269\|PubMed:14979715, ECO:0000269\|PubMed:14996743, ECO:0000269\|PubMed:15087468

Chain	Residue	Details
A	THR23
A	ASP50
A	SER166
A	GLN190
A	TYR216
A	LYS270
A	ARG276

site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	HIS117

site_id	SWS_FT_FI4
Number of Residues	1
Details	SITE: Important for substrate specificity => ECO:0000250

Chain	Residue	Details
A	LEU54

site_id	SWS_FT_FI5
Number of Residues	1
Details	SITE: Lowers pKa of active site Tyr => ECO:0000250\|UniProtKB:P14550

Chain	Residue	Details
A	LYS84

site_id	SWS_FT_FI6
Number of Residues	2
Details	SITE: Involved in ligand recognition and product release => ECO:0000269\|PubMed:15087468

Chain	Residue	Details
A	TRP227
A	PHE306

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)