4F8Z

Carboxypeptidase T with Boc-Leu

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004181	molecular_function	metallocarboxypeptidase activity
A	0006508	biological_process	proteolysis
A	0008270	molecular_function	zinc ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 401

Chain	Residue
A	HIS69
A	GLU72
A	HIS204
A	BL2402

---

site_id	AC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE BL2 A 402

Chain	Residue
A	THR205
A	TYR206
A	SER207
A	TYR255
A	GLU277
A	PHE287
A	ZN401
A	SO4403
A	HOH507
A	HIS69
A	ARG71
A	GLU72
A	ARG129
A	HIS204

---

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 403

Chain	Residue
A	HIS69
A	ARG129
A	ASN146
A	ARG147
A	TYR255
A	GLU277
A	BL2402
A	GOL413

---

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 404

Chain	Residue
A	PHE174
A	ARG183
A	ASN187
A	TRP264
A	GLN268
A	HOH622
A	HOH643
A	HOH809

---

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 405

Chain	Residue
A	VAL16
A	ASN20
A	ASN25
A	LYS32
A	TRP45
A	HOH533
A	HOH841

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 406

Chain	Residue
A	SER50
A	ASP51
A	GLU57
A	GLU59
A	HOH506

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 407

Chain	Residue
A	ASP56
A	GLU57
A	GLU61
A	GLU104
A	HOH646
A	HOH800

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA A 408

Chain	Residue
A	ASP51
A	GLU57
A	GLU59
A	ASN101

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 409

Chain	Residue
A	SER7
A	TYR9
A	GLU14
A	HOH501
A	HOH555
A	HOH866

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 410

Chain	Residue
A	PRO3
A	SER4
A	TYR5
A	HOH759
A	HOH781

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 411

Chain	Residue
A	HIS10
A	LYS18
A	HOH603
A	HOH675

---

site_id	BC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 412

Chain	Residue
A	HIS10
A	LYS18
A	GLU77
A	LEU80
A	TYR81
A	ASP84
A	ILE294
A	HOH634
A	HOH758

---

site_id	BC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 413

Chain	Residue
A	ASN146
A	LEU211
A	ALA251
A	THR257
A	ASP260
A	SO4403
A	HOH737
A	HOH810

---

site_id	BC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 414

Chain	Residue
A	TRP128
A	TYR140
A	VAL141
A	GOL415
A	HOH552
A	HOH589
A	HOH623
A	HOH693
A	HOH726

---

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 415

Chain	Residue
A	GOL414
A	SER139
A	TYR140

---

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 416

Chain	Residue
A	PHE33
A	ASP184
A	PHE185
A	GOL417
A	HOH539
A	HOH897

---

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 417

Chain	Residue
A	LYS48
A	TYR106
A	GOL416
A	HOH556

---

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 418

Chain	Residue
A	GLY193
A	GLN195
A	HIS269
A	HOH694
A	HOH805
A	HOH831

---

site_id	CC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GOL A 419

Chain	Residue
A	VAL221
A	PRO222
A	SER223
A	TYR283
A	ASN284
A	PRO285
A	GOL421
A	HOH518
A	HOH580
A	HOH630
A	HOH682

---

site_id	CC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 420

Chain	Residue
A	THR226
A	GLN227
A	ASP228
A	HOH820
A	HOH833
A	HOH890

---

site_id	CC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 421

Chain	Residue
A	SER223
A	TYR288
A	GOL419
A	HOH585
A	HOH587
A	HOH630
A	HOH801
A	HOH862

---

site_id	CC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 422

Chain	Residue
A	SER138
A	SER139
A	TYR140
A	ARG171
A	SER172
A	HOH547
A	HOH620

---

site_id	CC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 423

Chain	Residue
A	TYR39
A	GLN133
A	PRO134
A	ARG171
A	GOL427
A	HOH685
A	HOH742
A	HOH826

---

site_id	CC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 424

Chain	Residue
A	ARG296
A	SER299
A	HOH772
A	HOH799

---

site_id	CC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 425

Chain	Residue
A	ASP1
A	ASN11
A	GLU117
A	ILE120
A	HOH548
A	HOH701
A	HOH881

---

site_id	CC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 426

Chain	Residue
A	SER207
A	THR247
A	THR281
A	HOH669
A	HOH806

---

site_id	CC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 427

Chain	Residue
A	PHE174
A	SER175
A	PRO177
A	ALA180
A	GOL423
A	HOH566
A	HOH826
A	HOH851

---

site_id	DC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 428

Chain	Residue
A	THR239
A	TYR307
A	LYS311
A	HOH787
A	HOH843

---

site_id	DC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 429

Chain	Residue
A	TYR12
A	ARG42
A	GLU117
A	GOL431

---

site_id	DC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 430

Chain	Residue
A	TYR81
A	ASP84
A	LEU85
A	GLN88
A	ASN89
A	HOH818
A	HOH840

---

site_id	DC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 431

Chain	Residue
A	GLU40
A	GLY41
A	GOL429

---

Functional Information from PROSITE/UniProt

site_id	PS00132
Number of Residues	23
Details	CARBOXYPEPT_ZN_1 Zinc carboxypeptidases, zinc-binding region 1 signature. PeVlYtaLhHArEhLTVemalyT

Chain	Residue	Details
A	PRO60-THR82

---

site_id	PS00133
Number of Residues	11
Details	CARBOXYPEPT_ZN_2 Zinc carboxypeptidases, zinc-binding region 2 signature. HTYSELIlYPY

Chain	Residue	Details
A	HIS204-TYR214

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	304
Details	Domain: {"description":"Peptidase M14","evidences":[{"source":"PROSITE-ProRule","id":"PRU01379","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU01379","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"1521526","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01379","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"1521526","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---