Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| B | 0000307 | cellular_component | cyclin-dependent protein kinase holoenzyme complex |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
| B | 0016538 | molecular_function | cyclin-dependent protein serine/threonine kinase regulator activity |
| B | 0016592 | cellular_component | mediator complex |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0045023 | biological_process | G0 to G1 transition |
| B | 0045746 | biological_process | negative regulation of Notch signaling pathway |
| B | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| B | 1990508 | cellular_component | CKM complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE 0SR A 501 |
| Chain | Residue |
| A | TYR32 |
| A | ALA100 |
| A | ILE171 |
| A | ALA172 |
| A | ASP173 |
| A | HOH668 |
| A | ALA50 |
| A | SER62 |
| A | ARG65 |
| A | GLU66 |
| A | LEU73 |
| A | ILE79 |
| A | PHE97 |
| A | ASP98 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA A 502 |
| Chain | Residue |
| A | HIS75 |
| A | ASP137 |
| A | HIS140 |
| A | HOH765 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DMS A 503 |
| Chain | Residue |
| A | PRO164 |
| A | ARG166 |
| A | ARG168 |
| A | SER343 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 504 |
| Chain | Residue |
| A | ARG71 |
| A | GLU72 |
| B | GLN7 |
| B | LEU12 |
| B | GLN13 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 505 |
| Chain | Residue |
| A | HIS249 |
| A | ASP282 |
| A | PHE283 |
| A | THR287 |
| A | TYR288 |
| A | HOH707 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 506 |
| Chain | Residue |
| A | LEU70 |
| A | ARG71 |
| A | LEU81 |
| A | EDO507 |
| A | HOH667 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 507 |
| Chain | Residue |
| A | ARG71 |
| A | LYS83 |
| A | VAL84 |
| A | EDO506 |
| B | ASP147 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 508 |
| Chain | Residue |
| A | PRO124 |
| A | GLY126 |
| A | MET127 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO A 509 |
| Chain | Residue |
| A | VAL16 |
| A | GLU17 |
| A | TYR22 |
| A | GLN53 |
| A | SER87 |
| A | ASP90 |
| A | LYS92 |
| A | TRP94 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE FMT A 511 |
| Chain | Residue |
| A | ARG65 |
| A | ARG150 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 301 |
| Chain | Residue |
| B | ALA0 |
| B | ALA2 |
| B | ILE151 |
| B | VAL152 |
| B | TYR153 |
| B | HOH442 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 302 |
| Chain | Residue |
| B | ASN46 |
| B | ARG185 |
| B | TRP241 |
| B | PHE244 |
| B | GLU246 |
| site_id | BC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO B 303 |
| Chain | Residue |
| B | GLN161 |
| B | TYR162 |
| site_id | BC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EDO B 304 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FMT B 305 |
| Chain | Residue |
| B | GLN41 |
| B | THR45 |
| B | THR66 |
| B | LYS70 |
| B | TYR184 |
| B | FMT307 |
| site_id | BC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE FMT B 306 |
| Chain | Residue |
| B | HIS54 |
| B | LEU55 |
| B | ARG107 |
| B | HOH444 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE FMT B 307 |
| Chain | Residue |
| B | TYR37 |
| B | GLN41 |
| B | FMT305 |
| B | HOH478 |
| site_id | BC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FMT B 308 |
| Chain | Residue |
| B | LYS126 |
| B | GLU127 |
| B | PRO129 |
| B | HOH506 |
| B | HOH513 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 26 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGRGTYGHVYkAkrkdgkddkd........YALK |
| Chain | Residue | Details |
| A | VAL27-LYS52 | |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VlHrDLKpaNILV |
| Chain | Residue | Details |
| A | VAL147-VAL159 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| B | SER275 | |
| Chain | Residue | Details |
| A | VAL27 | |
| A | LYS52 | |
