Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4F61

Tubulin:Stathmin-like domain complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000226	biological_process	microtubule cytoskeleton organization
A	0000793	cellular_component	condensed chromosome
A	0001764	biological_process	neuron migration
A	0001964	biological_process	startle response
A	0005200	molecular_function	structural constituent of cytoskeleton
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005874	cellular_component	microtubule
A	0005879	cellular_component	axonemal microtubule
A	0005881	cellular_component	cytoplasmic microtubule
A	0005886	cellular_component	plasma membrane
A	0005929	cellular_component	cilium
A	0006886	biological_process	intracellular protein transport
A	0007017	biological_process	microtubule-based process
A	0007098	biological_process	centrosome cycle
A	0007224	biological_process	smoothened signaling pathway
A	0007613	biological_process	memory
A	0007626	biological_process	locomotory behavior
A	0008344	biological_process	adult locomotory behavior
A	0008542	biological_process	visual learning
A	0009612	biological_process	response to mechanical stimulus
A	0010001	biological_process	glial cell differentiation
A	0010467	biological_process	gene expression
A	0015630	cellular_component	microtubule cytoskeleton
A	0016787	molecular_function	hydrolase activity
A	0021542	biological_process	dentate gyrus development
A	0021696	biological_process	cerebellar cortex morphogenesis
A	0021766	biological_process	hippocampus development
A	0021859	biological_process	pyramidal neuron differentiation
A	0021987	biological_process	cerebral cortex development
A	0022008	biological_process	neurogenesis
A	0030182	biological_process	neuron differentiation
A	0030317	biological_process	flagellated sperm motility
A	0030534	biological_process	adult behavior
A	0031594	cellular_component	neuromuscular junction
A	0034612	biological_process	response to tumor necrosis factor
A	0035641	biological_process	locomotory exploration behavior
A	0036126	cellular_component	sperm flagellum
A	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
A	0042802	molecular_function	identical protein binding
A	0044877	molecular_function	protein-containing complex binding
A	0045202	cellular_component	synapse
A	0046785	biological_process	microtubule polymerization
A	0046872	molecular_function	metal ion binding
A	0046982	molecular_function	protein heterodimerization activity
A	0048853	biological_process	forebrain morphogenesis
A	0048873	biological_process	homeostasis of number of cells within a tissue
A	0050807	biological_process	regulation of synapse organization
A	0050808	biological_process	synapse organization
A	0051402	biological_process	neuron apoptotic process
A	0055037	cellular_component	recycling endosome
A	0061744	biological_process	motor behavior
A	0071277	biological_process	cellular response to calcium ion
A	0072384	biological_process	organelle transport along microtubule
A	0140058	biological_process	neuron projection arborization
A	1902065	biological_process	response to L-glutamate
B	0000166	molecular_function	nucleotide binding
B	0003924	molecular_function	GTPase activity
B	0005200	molecular_function	structural constituent of cytoskeleton
B	0005525	molecular_function	GTP binding
B	0005737	cellular_component	cytoplasm
B	0005856	cellular_component	cytoskeleton
B	0005874	cellular_component	microtubule
B	0007010	biological_process	cytoskeleton organization
B	0007017	biological_process	microtubule-based process
B	0046872	molecular_function	metal ion binding
C	0000166	molecular_function	nucleotide binding
C	0000226	biological_process	microtubule cytoskeleton organization
C	0000793	cellular_component	condensed chromosome
C	0001764	biological_process	neuron migration
C	0001964	biological_process	startle response
C	0005200	molecular_function	structural constituent of cytoskeleton
C	0005525	molecular_function	GTP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005874	cellular_component	microtubule
C	0005879	cellular_component	axonemal microtubule
C	0005881	cellular_component	cytoplasmic microtubule
C	0005886	cellular_component	plasma membrane
C	0005929	cellular_component	cilium
C	0006886	biological_process	intracellular protein transport
C	0007017	biological_process	microtubule-based process
C	0007098	biological_process	centrosome cycle
C	0007224	biological_process	smoothened signaling pathway
C	0007613	biological_process	memory
C	0007626	biological_process	locomotory behavior
C	0008344	biological_process	adult locomotory behavior
C	0008542	biological_process	visual learning
C	0009612	biological_process	response to mechanical stimulus
C	0010001	biological_process	glial cell differentiation
C	0010467	biological_process	gene expression
C	0015630	cellular_component	microtubule cytoskeleton
C	0016787	molecular_function	hydrolase activity
C	0021542	biological_process	dentate gyrus development
C	0021696	biological_process	cerebellar cortex morphogenesis
C	0021766	biological_process	hippocampus development
C	0021859	biological_process	pyramidal neuron differentiation
C	0021987	biological_process	cerebral cortex development
C	0022008	biological_process	neurogenesis
C	0030182	biological_process	neuron differentiation
C	0030317	biological_process	flagellated sperm motility
C	0030534	biological_process	adult behavior
C	0031594	cellular_component	neuromuscular junction
C	0034612	biological_process	response to tumor necrosis factor
C	0035641	biological_process	locomotory exploration behavior
C	0036126	cellular_component	sperm flagellum
C	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
C	0042802	molecular_function	identical protein binding
C	0044877	molecular_function	protein-containing complex binding
C	0045202	cellular_component	synapse
C	0046785	biological_process	microtubule polymerization
C	0046872	molecular_function	metal ion binding
C	0046982	molecular_function	protein heterodimerization activity
C	0048853	biological_process	forebrain morphogenesis
C	0048873	biological_process	homeostasis of number of cells within a tissue
C	0050807	biological_process	regulation of synapse organization
C	0050808	biological_process	synapse organization
C	0051402	biological_process	neuron apoptotic process
C	0055037	cellular_component	recycling endosome
C	0061744	biological_process	motor behavior
C	0071277	biological_process	cellular response to calcium ion
C	0072384	biological_process	organelle transport along microtubule
C	0140058	biological_process	neuron projection arborization
C	1902065	biological_process	response to L-glutamate
D	0000166	molecular_function	nucleotide binding
D	0003924	molecular_function	GTPase activity
D	0005200	molecular_function	structural constituent of cytoskeleton
D	0005525	molecular_function	GTP binding
D	0005737	cellular_component	cytoplasm
D	0005856	cellular_component	cytoskeleton
D	0005874	cellular_component	microtubule
D	0007010	biological_process	cytoskeleton organization
D	0007017	biological_process	microtubule-based process
D	0046872	molecular_function	metal ion binding
E	0000166	molecular_function	nucleotide binding
E	0000226	biological_process	microtubule cytoskeleton organization
E	0000793	cellular_component	condensed chromosome
E	0001764	biological_process	neuron migration
E	0001964	biological_process	startle response
E	0005200	molecular_function	structural constituent of cytoskeleton
E	0005525	molecular_function	GTP binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0005874	cellular_component	microtubule
E	0005879	cellular_component	axonemal microtubule
E	0005881	cellular_component	cytoplasmic microtubule
E	0005886	cellular_component	plasma membrane
E	0005929	cellular_component	cilium
E	0006886	biological_process	intracellular protein transport
E	0007017	biological_process	microtubule-based process
E	0007098	biological_process	centrosome cycle
E	0007224	biological_process	smoothened signaling pathway
E	0007613	biological_process	memory
E	0007626	biological_process	locomotory behavior
E	0008344	biological_process	adult locomotory behavior
E	0008542	biological_process	visual learning
E	0009612	biological_process	response to mechanical stimulus
E	0010001	biological_process	glial cell differentiation
E	0010467	biological_process	gene expression
E	0015630	cellular_component	microtubule cytoskeleton
E	0016787	molecular_function	hydrolase activity
E	0021542	biological_process	dentate gyrus development
E	0021696	biological_process	cerebellar cortex morphogenesis
E	0021766	biological_process	hippocampus development
E	0021859	biological_process	pyramidal neuron differentiation
E	0021987	biological_process	cerebral cortex development
E	0022008	biological_process	neurogenesis
E	0030182	biological_process	neuron differentiation
E	0030317	biological_process	flagellated sperm motility
E	0030534	biological_process	adult behavior
E	0031594	cellular_component	neuromuscular junction
E	0034612	biological_process	response to tumor necrosis factor
E	0035641	biological_process	locomotory exploration behavior
E	0036126	cellular_component	sperm flagellum
E	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
E	0042802	molecular_function	identical protein binding
E	0044877	molecular_function	protein-containing complex binding
E	0045202	cellular_component	synapse
E	0046785	biological_process	microtubule polymerization
E	0046872	molecular_function	metal ion binding
E	0046982	molecular_function	protein heterodimerization activity
E	0048853	biological_process	forebrain morphogenesis
E	0048873	biological_process	homeostasis of number of cells within a tissue
E	0050807	biological_process	regulation of synapse organization
E	0050808	biological_process	synapse organization
E	0051402	biological_process	neuron apoptotic process
E	0055037	cellular_component	recycling endosome
E	0061744	biological_process	motor behavior
E	0071277	biological_process	cellular response to calcium ion
E	0072384	biological_process	organelle transport along microtubule
E	0140058	biological_process	neuron projection arborization
E	1902065	biological_process	response to L-glutamate
F	0000166	molecular_function	nucleotide binding
F	0003924	molecular_function	GTPase activity
F	0005200	molecular_function	structural constituent of cytoskeleton
F	0005525	molecular_function	GTP binding
F	0005737	cellular_component	cytoplasm
F	0005856	cellular_component	cytoskeleton
F	0005874	cellular_component	microtubule
F	0007010	biological_process	cytoskeleton organization
F	0007017	biological_process	microtubule-based process
F	0046872	molecular_function	metal ion binding
G	0000166	molecular_function	nucleotide binding
G	0000226	biological_process	microtubule cytoskeleton organization
G	0000793	cellular_component	condensed chromosome
G	0001764	biological_process	neuron migration
G	0001964	biological_process	startle response
G	0005200	molecular_function	structural constituent of cytoskeleton
G	0005525	molecular_function	GTP binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005856	cellular_component	cytoskeleton
G	0005874	cellular_component	microtubule
G	0005879	cellular_component	axonemal microtubule
G	0005881	cellular_component	cytoplasmic microtubule
G	0005886	cellular_component	plasma membrane
G	0005929	cellular_component	cilium
G	0006886	biological_process	intracellular protein transport
G	0007017	biological_process	microtubule-based process
G	0007098	biological_process	centrosome cycle
G	0007224	biological_process	smoothened signaling pathway
G	0007613	biological_process	memory
G	0007626	biological_process	locomotory behavior
G	0008344	biological_process	adult locomotory behavior
G	0008542	biological_process	visual learning
G	0009612	biological_process	response to mechanical stimulus
G	0010001	biological_process	glial cell differentiation
G	0010467	biological_process	gene expression
G	0015630	cellular_component	microtubule cytoskeleton
G	0016787	molecular_function	hydrolase activity
G	0021542	biological_process	dentate gyrus development
G	0021696	biological_process	cerebellar cortex morphogenesis
G	0021766	biological_process	hippocampus development
G	0021859	biological_process	pyramidal neuron differentiation
G	0021987	biological_process	cerebral cortex development
G	0022008	biological_process	neurogenesis
G	0030182	biological_process	neuron differentiation
G	0030317	biological_process	flagellated sperm motility
G	0030534	biological_process	adult behavior
G	0031594	cellular_component	neuromuscular junction
G	0034612	biological_process	response to tumor necrosis factor
G	0035641	biological_process	locomotory exploration behavior
G	0036126	cellular_component	sperm flagellum
G	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
G	0042802	molecular_function	identical protein binding
G	0044877	molecular_function	protein-containing complex binding
G	0045202	cellular_component	synapse
G	0046785	biological_process	microtubule polymerization
G	0046872	molecular_function	metal ion binding
G	0046982	molecular_function	protein heterodimerization activity
G	0048853	biological_process	forebrain morphogenesis
G	0048873	biological_process	homeostasis of number of cells within a tissue
G	0050807	biological_process	regulation of synapse organization
G	0050808	biological_process	synapse organization
G	0051402	biological_process	neuron apoptotic process
G	0055037	cellular_component	recycling endosome
G	0061744	biological_process	motor behavior
G	0071277	biological_process	cellular response to calcium ion
G	0072384	biological_process	organelle transport along microtubule
G	0140058	biological_process	neuron projection arborization
G	1902065	biological_process	response to L-glutamate
H	0000166	molecular_function	nucleotide binding
H	0003924	molecular_function	GTPase activity
H	0005200	molecular_function	structural constituent of cytoskeleton
H	0005525	molecular_function	GTP binding
H	0005737	cellular_component	cytoplasm
H	0005856	cellular_component	cytoskeleton
H	0005874	cellular_component	microtubule
H	0007010	biological_process	cytoskeleton organization
H	0007017	biological_process	microtubule-based process
H	0046872	molecular_function	metal ion binding
I	0031110	biological_process	regulation of microtubule polymerization or depolymerization

Functional Information from PDB Data

site_id	AC1
Number of Residues	25
Details	BINDING SITE FOR RESIDUE GTP A 600

Chain	Residue
A	GLY10
A	ASN101
A	SER140
A	GLY143
A	GLY144
A	THR145
A	GLY146
A	ILE171
A	VAL177
A	THR179
A	GLU183
A	GLN11
A	ASN206
A	TYR224
A	ASN228
A	ILE231
A	MG601
B	LYS254
A	ALA12
A	GLN15
A	ASP69
A	GLU71
A	ASP98
A	ALA99
A	ALA100

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG A 601

Chain	Residue
A	GLU71
A	GTP600

site_id	AC3
Number of Residues	17
Details	BINDING SITE FOR RESIDUE GDP B 600

Chain	Residue
B	GLY10
B	GLN11
B	CYS12
B	GLN15
B	ASN101
B	SER140
B	GLY143
B	GLY144
B	THR145
B	GLY146
B	PRO173
B	VAL177
B	ASP179
B	GLU183
B	ASN206
B	TYR224
B	ASN228

site_id	AC4
Number of Residues	25
Details	BINDING SITE FOR RESIDUE GTP C 600

Chain	Residue
C	GLY10
C	GLN11
C	ALA12
C	GLN15
C	ASP69
C	GLU71
C	ASP98
C	ALA99
C	ALA100
C	ASN101
C	SER140
C	GLY143
C	GLY144
C	THR145
C	GLY146
C	ILE171
C	VAL177
C	THR179
C	GLU183
C	ASN206
C	TYR224
C	ASN228
C	ILE231
C	MG601
D	LYS254

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG C 601

Chain	Residue
C	GLU71
C	GTP600

site_id	AC6
Number of Residues	17
Details	BINDING SITE FOR RESIDUE GDP D 600

Chain	Residue
D	GLY10
D	GLN11
D	CYS12
D	GLN15
D	ASN101
D	SER140
D	GLY143
D	GLY144
D	THR145
D	GLY146
D	PRO173
D	VAL177
D	ASP179
D	GLU183
D	ASN206
D	TYR224
D	ASN228

site_id	AC7
Number of Residues	25
Details	BINDING SITE FOR RESIDUE GTP E 600

Chain	Residue
E	GLY143
E	GLY144
E	THR145
E	GLY146
E	ILE171
E	VAL177
E	THR179
E	GLU183
E	ASN206
E	TYR224
E	ASN228
E	ILE231
E	MG601
F	LYS254
E	GLY10
E	GLN11
E	ALA12
E	GLN15
E	ASP69
E	GLU71
E	ASP98
E	ALA99
E	ALA100
E	ASN101
E	SER140

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG E 601

Chain	Residue
E	GLU71
E	GTP600

site_id	AC9
Number of Residues	17
Details	BINDING SITE FOR RESIDUE GDP F 600

Chain	Residue
F	GLY10
F	GLN11
F	CYS12
F	GLN15
F	ASN101
F	SER140
F	GLY143
F	GLY144
F	THR145
F	GLY146
F	PRO173
F	VAL177
F	ASP179
F	GLU183
F	ASN206
F	TYR224
F	ASN228

site_id	BC1
Number of Residues	25
Details	BINDING SITE FOR RESIDUE GTP G 600

Chain	Residue
G	GLY10
G	GLN11
G	ALA12
G	GLN15
G	ASP69
G	GLU71
G	ASP98
G	ALA99
G	ALA100
G	ASN101
G	SER140
G	GLY143
G	GLY144
G	THR145
G	GLY146
G	ILE171
G	VAL177
G	THR179
G	GLU183
G	ASN206
G	TYR224
G	ASN228
G	ILE231
G	MG601
H	LYS254

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG G 601

Chain	Residue
G	GLU71
G	GTP600
H	LYS254

site_id	BC3
Number of Residues	16
Details	BINDING SITE FOR RESIDUE GDP H 600

Chain	Residue
H	GLY10
H	GLN11
H	CYS12
H	GLN15
H	ASN101
H	SER140
H	GLY143
H	GLY144
H	THR145
H	GLY146
H	PRO173
H	SER178
H	GLU183
H	ASN206
H	TYR224
H	ASN228

Functional Information from PROSITE/UniProt

site_id	PS00227
Number of Residues	7
Details	TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG

Chain	Residue	Details
B	GLY142-GLY148
A	GLY142-GLY148

site_id	PS00228
Number of Residues	4
Details	TUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI

Chain	Residue	Details
B	MET1-ILE4

site_id	PS00563
Number of Residues	10
Details	STATHMIN_1 Stathmin family signature 1. PRRRDpSLEE

Chain	Residue	Details
I	PRO40-GLU49

site_id	PS01041
Number of Residues	10
Details	STATHMIN_2 Stathmin family signature 2. AEKREHEREV

Chain	Residue	Details
I	ALA73-VAL82
I	ALA175-VAL184

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)