4F4Q
Crystal structure of M. smegmatis DprE1 in complex with FAD and covalently bound BTZ043
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003885 | molecular_function | D-arabinono-1,4-lactone oxidase activity |
| A | 0016020 | cellular_component | membrane |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016899 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor |
| A | 0042597 | cellular_component | periplasmic space |
| A | 0045227 | biological_process | capsule polysaccharide biosynthetic process |
| A | 0046677 | biological_process | response to antibiotic |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| A | 0071555 | biological_process | cell wall organization |
| A | 0071949 | molecular_function | FAD binding |
| A | 0080049 | molecular_function | L-gulono-1,4-lactone dehydrogenase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 0SK A 501 |
| Chain | Residue |
| A | GLY124 |
| A | LYS425 |
| A | FAD502 |
| A | HOH680 |
| A | HIS139 |
| A | GLY140 |
| A | LYS141 |
| A | LEU370 |
| A | VAL372 |
| A | LYS374 |
| A | ASN392 |
| A | CYS394 |
| site_id | AC2 |
| Number of Residues | 32 |
| Details | BINDING SITE FOR RESIDUE FAD A 502 |
| Chain | Residue |
| A | TRP24 |
| A | ILE59 |
| A | ALA60 |
| A | GLY62 |
| A | LEU63 |
| A | GLY64 |
| A | ARG65 |
| A | SER66 |
| A | TYR67 |
| A | ASN70 |
| A | ALA71 |
| A | MET81 |
| A | ALA101 |
| A | PRO123 |
| A | GLY124 |
| A | VAL128 |
| A | THR129 |
| A | GLY131 |
| A | GLY132 |
| A | CYS136 |
| A | ILE138 |
| A | HIS139 |
| A | ASN185 |
| A | GLY186 |
| A | GLY189 |
| A | ILE191 |
| A | TYR422 |
| A | ALA424 |
| A | 0SK501 |
| A | HOH601 |
| A | HOH641 |
| A | HOH680 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 174 |
| Details | Domain: {"description":"FAD-binding PCMH-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00718","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 19 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22956199","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4AUT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F4Q","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
