Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4F4O

Structure of the Haptoglobin-Haemoglobin Complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004601	molecular_function	peroxidase activity
A	0005344	molecular_function	oxygen carrier activity
A	0005506	molecular_function	iron ion binding
A	0005515	molecular_function	protein binding
A	0005833	cellular_component	hemoglobin complex
A	0015671	biological_process	oxygen transport
A	0019825	molecular_function	oxygen binding
A	0020037	molecular_function	heme binding
A	0031720	molecular_function	haptoglobin binding
A	0031838	cellular_component	haptoglobin-hemoglobin complex
A	0042744	biological_process	hydrogen peroxide catabolic process
A	0043177	molecular_function	organic acid binding
A	0046872	molecular_function	metal ion binding
A	0072562	cellular_component	blood microparticle
A	0098869	biological_process	cellular oxidant detoxification
B	0004601	molecular_function	peroxidase activity
B	0005344	molecular_function	oxygen carrier activity
B	0005515	molecular_function	protein binding
B	0005833	cellular_component	hemoglobin complex
B	0015671	biological_process	oxygen transport
B	0019825	molecular_function	oxygen binding
B	0020037	molecular_function	heme binding
B	0031720	molecular_function	haptoglobin binding
B	0031721	molecular_function	hemoglobin alpha binding
B	0031838	cellular_component	haptoglobin-hemoglobin complex
B	0042744	biological_process	hydrogen peroxide catabolic process
B	0043177	molecular_function	organic acid binding
B	0046872	molecular_function	metal ion binding
B	0072562	cellular_component	blood microparticle
B	0098869	biological_process	cellular oxidant detoxification
C	0004252	molecular_function	serine-type endopeptidase activity
C	0005576	cellular_component	extracellular region
C	0006508	biological_process	proteolysis
C	0030492	molecular_function	hemoglobin binding
D	0004601	molecular_function	peroxidase activity
D	0005344	molecular_function	oxygen carrier activity
D	0005506	molecular_function	iron ion binding
D	0005515	molecular_function	protein binding
D	0005833	cellular_component	hemoglobin complex
D	0015671	biological_process	oxygen transport
D	0019825	molecular_function	oxygen binding
D	0020037	molecular_function	heme binding
D	0031720	molecular_function	haptoglobin binding
D	0031838	cellular_component	haptoglobin-hemoglobin complex
D	0042744	biological_process	hydrogen peroxide catabolic process
D	0043177	molecular_function	organic acid binding
D	0046872	molecular_function	metal ion binding
D	0072562	cellular_component	blood microparticle
D	0098869	biological_process	cellular oxidant detoxification
E	0004601	molecular_function	peroxidase activity
E	0005344	molecular_function	oxygen carrier activity
E	0005515	molecular_function	protein binding
E	0005833	cellular_component	hemoglobin complex
E	0015671	biological_process	oxygen transport
E	0019825	molecular_function	oxygen binding
E	0020037	molecular_function	heme binding
E	0031720	molecular_function	haptoglobin binding
E	0031721	molecular_function	hemoglobin alpha binding
E	0031838	cellular_component	haptoglobin-hemoglobin complex
E	0042744	biological_process	hydrogen peroxide catabolic process
E	0043177	molecular_function	organic acid binding
E	0046872	molecular_function	metal ion binding
E	0072562	cellular_component	blood microparticle
E	0098869	biological_process	cellular oxidant detoxification
F	0004252	molecular_function	serine-type endopeptidase activity
F	0005576	cellular_component	extracellular region
F	0006508	biological_process	proteolysis
F	0030492	molecular_function	hemoglobin binding
G	0004601	molecular_function	peroxidase activity
G	0005344	molecular_function	oxygen carrier activity
G	0005506	molecular_function	iron ion binding
G	0005515	molecular_function	protein binding
G	0005833	cellular_component	hemoglobin complex
G	0015671	biological_process	oxygen transport
G	0019825	molecular_function	oxygen binding
G	0020037	molecular_function	heme binding
G	0031720	molecular_function	haptoglobin binding
G	0031838	cellular_component	haptoglobin-hemoglobin complex
G	0042744	biological_process	hydrogen peroxide catabolic process
G	0043177	molecular_function	organic acid binding
G	0046872	molecular_function	metal ion binding
G	0072562	cellular_component	blood microparticle
G	0098869	biological_process	cellular oxidant detoxification
H	0004601	molecular_function	peroxidase activity
H	0005344	molecular_function	oxygen carrier activity
H	0005515	molecular_function	protein binding
H	0005833	cellular_component	hemoglobin complex
H	0015671	biological_process	oxygen transport
H	0019825	molecular_function	oxygen binding
H	0020037	molecular_function	heme binding
H	0031720	molecular_function	haptoglobin binding
H	0031721	molecular_function	hemoglobin alpha binding
H	0031838	cellular_component	haptoglobin-hemoglobin complex
H	0042744	biological_process	hydrogen peroxide catabolic process
H	0043177	molecular_function	organic acid binding
H	0046872	molecular_function	metal ion binding
H	0072562	cellular_component	blood microparticle
H	0098869	biological_process	cellular oxidant detoxification
I	0004252	molecular_function	serine-type endopeptidase activity
I	0005576	cellular_component	extracellular region
I	0006508	biological_process	proteolysis
I	0030492	molecular_function	hemoglobin binding
J	0004601	molecular_function	peroxidase activity
J	0005344	molecular_function	oxygen carrier activity
J	0005506	molecular_function	iron ion binding
J	0005515	molecular_function	protein binding
J	0005833	cellular_component	hemoglobin complex
J	0015671	biological_process	oxygen transport
J	0019825	molecular_function	oxygen binding
J	0020037	molecular_function	heme binding
J	0031720	molecular_function	haptoglobin binding
J	0031838	cellular_component	haptoglobin-hemoglobin complex
J	0042744	biological_process	hydrogen peroxide catabolic process
J	0043177	molecular_function	organic acid binding
J	0046872	molecular_function	metal ion binding
J	0072562	cellular_component	blood microparticle
J	0098869	biological_process	cellular oxidant detoxification
K	0004601	molecular_function	peroxidase activity
K	0005344	molecular_function	oxygen carrier activity
K	0005515	molecular_function	protein binding
K	0005833	cellular_component	hemoglobin complex
K	0015671	biological_process	oxygen transport
K	0019825	molecular_function	oxygen binding
K	0020037	molecular_function	heme binding
K	0031720	molecular_function	haptoglobin binding
K	0031721	molecular_function	hemoglobin alpha binding
K	0031838	cellular_component	haptoglobin-hemoglobin complex
K	0042744	biological_process	hydrogen peroxide catabolic process
K	0043177	molecular_function	organic acid binding
K	0046872	molecular_function	metal ion binding
K	0072562	cellular_component	blood microparticle
K	0098869	biological_process	cellular oxidant detoxification
L	0004252	molecular_function	serine-type endopeptidase activity
L	0005576	cellular_component	extracellular region
L	0006508	biological_process	proteolysis
L	0030492	molecular_function	hemoglobin binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:22922649

Chain	Residue	Details
C	ASN125
I	ASN151
I	ASN183
I	ASN232
L	ASN125
L	ASN151
L	ASN183
L	ASN232
C	ASN151
C	ASN183
C	ASN232
F	ASN125
F	ASN151
F	ASN183
F	ASN232
I	ASN125

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: proximal binding residue => ECO:0000255\|PROSITE-ProRule:PRU00238, ECO:0000269\|PubMed:10713517, ECO:0000269\|PubMed:7990139, ECO:0007744\|PDB:1QPW, ECO:0007744\|PDB:2PGH, ECO:0007744\|PDB:4F4O

Chain	Residue	Details
B	HIS92
E	HIS92
H	HIS92
K	HIS92

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: N-acetylvaline => ECO:0000250\|UniProtKB:P02086

Chain	Residue	Details
B	VAL1
E	VAL1
H	VAL1
K	VAL1
G	SER3
G	SER49
J	SER3
J	SER49

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P68871

Chain	Residue	Details
B	SER44
J	LYS7
J	LYS11
J	LYS40
E	SER44
H	SER44
K	SER44
D	LYS11
D	LYS40
G	LYS7
G	LYS11
G	LYS40

site_id	SWS_FT_FI5
Number of Residues	12
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:P68871

Chain	Residue	Details
B	LYS59
K	LYS59
K	LYS82
K	LYS144
B	LYS82
B	LYS144
E	LYS59
E	LYS82
E	LYS144
H	LYS59
H	LYS82
H	LYS144

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: S-nitrosocysteine => ECO:0000250\|UniProtKB:P68871

Chain	Residue	Details
B	CYS93
J	SER102
J	SER124
J	SER138
E	CYS93
H	CYS93
K	CYS93
D	SER124
D	SER138
G	SER102
G	SER124
G	SER138

site_id	SWS_FT_FI7
Number of Residues	12
Details	MOD_RES: Phosphothreonine => ECO:0000250\|UniProtKB:P01942

Chain	Residue	Details
A	THR108
J	THR108
J	THR134
J	THR137
A	THR134
A	THR137
D	THR108
D	THR134
D	THR137
G	THR108
G	THR134
G	THR137

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)