4F4C

The Crystal Structure of the Multi-Drug Transporter

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0008559	molecular_function	ABC-type xenobiotic transporter activity
A	0010038	biological_process	response to metal ion
A	0015562	molecular_function	efflux transmembrane transporter activity
A	0016020	cellular_component	membrane
A	0016324	cellular_component	apical plasma membrane
A	0016887	molecular_function	ATP hydrolysis activity
A	0042626	molecular_function	ATPase-coupled transmembrane transporter activity
A	0042908	biological_process	xenobiotic transport
A	0045087	biological_process	innate immune response
A	0050829	biological_process	defense response to Gram-negative bacterium
A	0055085	biological_process	transmembrane transport
A	0093002	biological_process	response to nematicide
A	0140359	molecular_function	ABC-type transporter activity

Functional Information from PROSITE/UniProt

site_id	PS00211
Number of Residues	15
Details	ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQKQRIAIARAL

Chain	Residue	Details
A	LEU555-LEU569
A	LEU1218-LEU1232

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	741
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	MET1-LEU77
A	LEU371-SER753
A	PHE1038-LYS1321

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site_id	SWS_FT_FI2
Number of Residues	240
Details	TRANSMEM: Helical => ECO:0000255|PROSITE-ProRule:PRU00441

Chain	Residue	Details
A	PHE78-GLN98
A	GLY895-LEU915
A	ILE978-TYR998
A	VAL1017-TYR1037
A	ALA144-ALA164
A	LYS213-THR233
A	LEU240-MET260
A	ILE321-GLY341
A	LEU350-GLY370
A	LEU754-PHE774
A	LEU798-MET818
A	PHE874-TYR894

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site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00434

Chain	Residue	Details
A	GLY451
A	GLY1112

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site_id	SWS_FT_FI4
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN115
A	ASN125
A	ASN190
A	ASN850

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