4F4A

Crystal structure of Nucleoside diphosphate kinase B from Trypanosoma brucei, UDP-bound form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004550	molecular_function	nucleoside diphosphate kinase activity
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0006183	biological_process	GTP biosynthetic process
A	0006228	biological_process	UTP biosynthetic process
A	0006241	biological_process	CTP biosynthetic process
A	0009142	biological_process	nucleoside triphosphate biosynthetic process
A	0010608	biological_process	post-transcriptional regulation of gene expression
A	0016301	molecular_function	kinase activity
A	0097014	cellular_component	ciliary plasm
B	0004550	molecular_function	nucleoside diphosphate kinase activity
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0006183	biological_process	GTP biosynthetic process
B	0006228	biological_process	UTP biosynthetic process
B	0006241	biological_process	CTP biosynthetic process
B	0009142	biological_process	nucleoside triphosphate biosynthetic process
B	0010608	biological_process	post-transcriptional regulation of gene expression
B	0016301	molecular_function	kinase activity
B	0097014	cellular_component	ciliary plasm
C	0004550	molecular_function	nucleoside diphosphate kinase activity
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0006183	biological_process	GTP biosynthetic process
C	0006228	biological_process	UTP biosynthetic process
C	0006241	biological_process	CTP biosynthetic process
C	0009142	biological_process	nucleoside triphosphate biosynthetic process
C	0010608	biological_process	post-transcriptional regulation of gene expression
C	0016301	molecular_function	kinase activity
C	0097014	cellular_component	ciliary plasm

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE UDP A 201

Chain	Residue
A	LYS11
A	MG202
A	HOH311
A	HOH316
A	HOH330
A	HOH384
A	HOH385
A	HOH407
A	TYR51
A	LEU54
A	PHE59
A	LEU63
A	ARG87
A	THR93
A	VAL111
A	ASN114

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site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG A 202

Chain	Residue
A	UDP201
A	HOH384
A	HOH385

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site_id	AC3
Number of Residues	16
Details	BINDING SITE FOR RESIDUE UDP B 201

Chain	Residue
B	LYS11
B	LEU54
B	PHE59
B	LEU63
B	ARG87
B	THR93
B	VAL111
B	GLY112
B	ASN114
B	MG202
B	HOH302
B	HOH356
B	HOH365
B	HOH395
B	HOH406
C	HOH420

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site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG B 202

Chain	Residue
B	UDP201
B	HOH356
B	HOH406

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site_id	AC5
Number of Residues	19
Details	BINDING SITE FOR RESIDUE UDP C 201

Chain	Residue
C	LYS11
C	TYR51
C	LEU54
C	PHE59
C	LEU63
C	ARG87
C	THR93
C	VAL111
C	ASN114
C	MG202
C	HOH312
C	HOH321
C	HOH381
C	HOH382
C	HOH383
C	HOH386
C	HOH387
C	HOH408
C	HOH435

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site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG C 202

Chain	Residue
C	UDP201
C	HOH381
C	HOH382
C	HOH383

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Functional Information from PROSITE/UniProt

site_id	PS00469
Number of Residues	9
Details	NDPK Nucleoside diphosphate kinase (NDPK) active site signature. NvcHGSDSV

Chain	Residue	Details
A	ASN114-VAL122

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