4F2Z

Crystal structure of RPE65 in a lipid environment

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001523	biological_process	retinoid metabolic process
A	0001786	molecular_function	phosphatidylserine binding
A	0001895	biological_process	retina homeostasis
A	0003834	molecular_function	beta-carotene 15,15'-dioxygenase activity
A	0004744	molecular_function	obsolete retinal isomerase activity
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005886	cellular_component	plasma membrane
A	0006629	biological_process	lipid metabolic process
A	0007601	biological_process	visual perception
A	0016020	cellular_component	membrane
A	0016702	molecular_function	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
A	0016787	molecular_function	hydrolase activity
A	0016853	molecular_function	isomerase activity
A	0031210	molecular_function	phosphatidylcholine binding
A	0042572	biological_process	retinol metabolic process
A	0042574	biological_process	retinal metabolic process
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
A	0050251	molecular_function	retinol isomerase activity
A	0050908	biological_process	detection of light stimulus involved in visual perception
A	0052884	molecular_function	all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity
A	0052885	molecular_function	all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity
A	1901612	molecular_function	cardiolipin binding
A	1901827	biological_process	zeaxanthin biosynthetic process
E	0001523	biological_process	retinoid metabolic process
E	0001786	molecular_function	phosphatidylserine binding
E	0001895	biological_process	retina homeostasis
E	0003834	molecular_function	beta-carotene 15,15'-dioxygenase activity
E	0004744	molecular_function	obsolete retinal isomerase activity
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005783	cellular_component	endoplasmic reticulum
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0005886	cellular_component	plasma membrane
E	0006629	biological_process	lipid metabolic process
E	0007601	biological_process	visual perception
E	0016020	cellular_component	membrane
E	0016702	molecular_function	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
E	0016787	molecular_function	hydrolase activity
E	0016853	molecular_function	isomerase activity
E	0031210	molecular_function	phosphatidylcholine binding
E	0042572	biological_process	retinol metabolic process
E	0042574	biological_process	retinal metabolic process
E	0042802	molecular_function	identical protein binding
E	0046872	molecular_function	metal ion binding
E	0050251	molecular_function	retinol isomerase activity
E	0050908	biological_process	detection of light stimulus involved in visual perception
E	0052884	molecular_function	all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity
E	0052885	molecular_function	all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity
E	1901612	molecular_function	cardiolipin binding
E	1901827	biological_process	zeaxanthin biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FE2 A 601

Chain	Residue
A	HIS180
A	HIS241
A	HIS313
A	HIS527

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FE2 E 601

Chain	Residue
E	HIS180
E	HIS241
E	HIS313
E	HIS527

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:19805034

Chain	Residue	Details
A	HIS180
A	HIS241
A	HIS313
A	HIS527
E	HIS180
E	HIS241
E	HIS313
E	HIS527

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: N-acetylserine => ECO:0000269|PubMed:15186777

Chain	Residue	Details
A	SER2
E	SER2

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q16518

Chain	Residue	Details
A	THR101
A	THR105
E	THR101
E	THR105

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q16518

Chain	Residue	Details
A	LYS113
E	LYS113

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q16518

Chain	Residue	Details
A	SER117
E	SER117

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	LIPID: S-palmitoyl cysteine; in membrane form => ECO:0000269|PubMed:19805034

Chain	Residue	Details
A	CYS112
E	CYS112

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	LIPID: S-palmitoyl cysteine; in membrane form => ECO:0000269|PubMed:15186777

Chain	Residue	Details
A	CYS231
A	CYS329
A	CYS330
E	CYS231
E	CYS329
E	CYS330

---