4F2W
Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Salmonella enterica with methyl-thio-DADMe-Immucillin-A
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0008782 | molecular_function | adenosylhomocysteine nucleosidase activity |
| A | 0008930 | molecular_function | methylthioadenosine nucleosidase activity |
| A | 0009116 | biological_process | nucleoside metabolic process |
| A | 0009164 | biological_process | nucleoside catabolic process |
| A | 0019509 | biological_process | L-methionine salvage from methylthioadenosine |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0008782 | molecular_function | adenosylhomocysteine nucleosidase activity |
| B | 0008930 | molecular_function | methylthioadenosine nucleosidase activity |
| B | 0009116 | biological_process | nucleoside metabolic process |
| B | 0009164 | biological_process | nucleoside catabolic process |
| B | 0019509 | biological_process | L-methionine salvage from methylthioadenosine |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE TDI A 301 |
| Chain | Residue |
| A | ALA8 |
| A | MET173 |
| A | GLU174 |
| A | SER196 |
| A | ASP197 |
| A | PHE207 |
| A | HOH403 |
| A | ILE50 |
| A | SER76 |
| A | ALA77 |
| A | GLY78 |
| A | ALA150 |
| A | PHE151 |
| A | ILE152 |
| A | GLU172 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO A 302 |
| Chain | Residue |
| A | ASN184 |
| A | ASN186 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 303 |
| Chain | Residue |
| A | HIS98 |
| A | ALA150 |
| A | HOH428 |
| A | HOH514 |
| B | HOH457 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 304 |
| Chain | Residue |
| A | ASP208 |
| A | HOH511 |
| B | ASP208 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 305 |
| Chain | Residue |
| A | PHE165 |
| A | PRO166 |
| A | ASP167 |
| A | HOH446 |
| site_id | AC6 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE TDI B 301 |
| Chain | Residue |
| B | ILE50 |
| B | SER76 |
| B | ALA77 |
| B | GLY78 |
| B | ALA150 |
| B | PHE151 |
| B | ILE152 |
| B | GLU172 |
| B | MET173 |
| B | GLU174 |
| B | SER196 |
| B | ASP197 |
| B | PHE207 |
| B | HOH423 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B 302 |
| Chain | Residue |
| B | HIS0 |
| B | ASP69 |
| B | SER82 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 303 |
| Chain | Residue |
| A | ASP123 |
| A | LYS124 |
| B | ASP21 |
| B | ASN22 |
| B | HOH490 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 304 |
| Chain | Residue |
| B | GLY154 |
| B | SER155 |
| B | ASP200 |
| B | GLN201 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 305 |
| Chain | Residue |
| B | PHE165 |
| B | PRO166 |
| B | ASP167 |
