4EZ1
Crystal structure of acetylcholine binding protein (AChBP) from Aplysia Californica in complex with alpha-conotoxin BuIA
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004888 | molecular_function | transmembrane signaling receptor activity |
A | 0005216 | molecular_function | monoatomic ion channel activity |
A | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
A | 0006811 | biological_process | monoatomic ion transport |
A | 0016020 | cellular_component | membrane |
A | 0034220 | biological_process | monoatomic ion transmembrane transport |
B | 0004888 | molecular_function | transmembrane signaling receptor activity |
B | 0005216 | molecular_function | monoatomic ion channel activity |
B | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
B | 0006811 | biological_process | monoatomic ion transport |
B | 0016020 | cellular_component | membrane |
B | 0034220 | biological_process | monoatomic ion transmembrane transport |
C | 0004888 | molecular_function | transmembrane signaling receptor activity |
C | 0005216 | molecular_function | monoatomic ion channel activity |
C | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
C | 0006811 | biological_process | monoatomic ion transport |
C | 0016020 | cellular_component | membrane |
C | 0034220 | biological_process | monoatomic ion transmembrane transport |
D | 0004888 | molecular_function | transmembrane signaling receptor activity |
D | 0005216 | molecular_function | monoatomic ion channel activity |
D | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
D | 0006811 | biological_process | monoatomic ion transport |
D | 0016020 | cellular_component | membrane |
D | 0034220 | biological_process | monoatomic ion transmembrane transport |
E | 0004888 | molecular_function | transmembrane signaling receptor activity |
E | 0005216 | molecular_function | monoatomic ion channel activity |
E | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
E | 0006811 | biological_process | monoatomic ion transport |
E | 0016020 | cellular_component | membrane |
E | 0034220 | biological_process | monoatomic ion transmembrane transport |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE NH2 K 14 |
Chain | Residue |
B | GLN57 |
K | CYS13 |
site_id | AC2 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE NH2 L 14 |
Chain | Residue |
A | ARG59 |
L | CYS13 |
site_id | AC3 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE NH2 M 14 |
Chain | Residue |
E | ASP159 |
M | CYS13 |
site_id | AC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE NH2 N 14 |
Chain | Residue |
D | MET116 |
N | ALA9 |
N | CYS13 |
site_id | AC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE NH2 O 14 |
Chain | Residue |
C | GLN57 |
C | ARG59 |
O | CYS13 |
site_id | AC6 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE MN C 301 |
Chain | Residue |
C | ASP-3 |
C | HIS1 |
site_id | AC7 |
Number of Residues | 17 |
Details | BINDING SITE FOR CHAIN K OF ALPHA-CONOTOXIN BUIA |
Chain | Residue |
B | GLN57 |
B | MET116 |
B | ILE118 |
B | ASP164 |
B | SER167 |
C | TYR93 |
C | SER146 |
C | TRP147 |
C | VAL148 |
C | TYR149 |
C | TYR188 |
C | CYS191 |
C | PRO192 |
C | GLU193 |
C | TYR195 |
C | HOH438 |
K | NH214 |
site_id | AC8 |
Number of Residues | 20 |
Details | BINDING SITE FOR CHAIN L OF ALPHA-CONOTOXIN BUIA |
Chain | Residue |
A | THR36 |
A | GLN57 |
A | ARG59 |
A | VAL108 |
A | MET116 |
A | ILE118 |
A | ASP164 |
A | SER166 |
A | SER167 |
B | TYR93 |
B | SER146 |
B | TRP147 |
B | TYR149 |
B | TYR188 |
B | CYS190 |
B | CYS191 |
B | GLU193 |
B | TYR195 |
B | HOH329 |
L | NH214 |
site_id | AC9 |
Number of Residues | 21 |
Details | BINDING SITE FOR CHAIN M OF ALPHA-CONOTOXIN BUIA |
Chain | Residue |
A | TYR93 |
A | SER146 |
A | TRP147 |
A | VAL148 |
A | TYR149 |
A | TYR188 |
A | CYS190 |
A | CYS191 |
A | PRO192 |
A | GLU193 |
A | TYR195 |
E | TYR55 |
E | GLN57 |
E | ARG79 |
E | VAL108 |
E | MET116 |
E | ILE118 |
E | ASP164 |
E | SER166 |
E | SER167 |
M | NH214 |
site_id | BC1 |
Number of Residues | 21 |
Details | BINDING SITE FOR CHAIN N OF ALPHA-CONOTOXIN BUIA |
Chain | Residue |
D | GLN57 |
D | ARG59 |
D | VAL108 |
D | MET116 |
D | ILE118 |
D | ASP164 |
D | SER166 |
D | SER167 |
E | TYR93 |
E | SER146 |
E | TRP147 |
E | VAL148 |
E | TYR149 |
E | TYR188 |
E | CYS190 |
E | CYS191 |
E | PRO192 |
E | GLU193 |
E | TYR195 |
E | HOH301 |
N | NH214 |
site_id | BC2 |
Number of Residues | 17 |
Details | BINDING SITE FOR CHAIN O OF ALPHA-CONOTOXIN BUIA |
Chain | Residue |
D | TYR93 |
D | SER146 |
D | TRP147 |
D | VAL148 |
D | TYR149 |
D | TYR188 |
D | CYS191 |
D | GLU193 |
D | TYR195 |
D | HOH306 |
O | NH214 |
A | SER189 |
C | GLN57 |
C | VAL108 |
C | MET116 |
C | ASP164 |
C | SER167 |
Functional Information from PROSITE/UniProt
site_id | PS60014 |
Number of Residues | 12 |
Details | ALPHA_CONOTOXIN Alpha-conotoxin family signature. CCStPPCAv...LYC |
Chain | Residue | Details |
K | CYS2-CYS13 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 5 |
Details | SITE: Critical residue for distinguishing between alpha-6-beta-2/CHRNA6-CHRNB2 and alpha-6-beta-4/CHRNA6-CHRNB4 nAChR subunits => ECO:0000269|PubMed:20739611 |
Chain | Residue | Details |
K | PRO6 | |
L | PRO6 | |
M | PRO6 | |
N | PRO6 | |
O | PRO6 |
site_id | SWS_FT_FI2 |
Number of Residues | 5 |
Details | MOD_RES: Cysteine amide => ECO:0000305|PubMed:15520009, ECO:0000305|PubMed:16964981, ECO:0000305|PubMed:16979596, ECO:0000305|PubMed:17445276, ECO:0000305|PubMed:20739611 |
Chain | Residue | Details |
K | CYS13 | |
L | CYS13 | |
M | CYS13 | |
N | CYS13 | |
O | CYS13 |