4EV4

Crystal structure of serratia fonticola carbapenemase SFC-1 E166A mutant with the acylenzyme intermediate of meropenem

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008800	molecular_function	beta-lactamase activity
A	0017001	biological_process	antibiotic catabolic process
A	0030655	biological_process	beta-lactam antibiotic catabolic process
A	0046677	biological_process	response to antibiotic

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE MER A 401

Chain	Residue
A	CYS69
A	HOH519
A	HOH546
A	HOH586
A	HOH757
A	SER70
A	SER130
A	ASN132
A	ASN170
A	LYS234
A	THR235
A	GLY236
A	THR237

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 402

Chain	Residue
A	PHE57
A	SER289
A	HOH516
A	HOH547
A	HOH665
A	HOH846

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site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 403

Chain	Residue
A	GLY156
A	ASN158
A	ALA185
A	GLU188
A	HOH510
A	HOH768

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site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 404

Chain	Residue
A	ARG94
A	THR115
A	GLY116
A	GLU121

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site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 405

Chain	Residue
A	ARG61
A	ALA62
A	ASN63
A	GLU64
A	HAR100
A	HOH525
A	HOH723

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