4EUE
Crystal structure of Clostridium acetobutulicum trans-2-enoyl-CoA reductase in complex with NADH
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004318 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADH) activity |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006631 | biological_process | fatty acid metabolic process |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016628 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor |
| A | 0050343 | molecular_function | trans-2-enoyl-CoA reductase (NADH) activity |
| A | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 34 |
| Details | BINDING SITE FOR RESIDUE NAI A 1001 |
| Chain | Residue |
| A | GLY47 |
| A | GLU110 |
| A | ASP111 |
| A | ALA112 |
| A | SER138 |
| A | LEU139 |
| A | ALA140 |
| A | ALA141 |
| A | TYR223 |
| A | SER224 |
| A | TYR225 |
| A | ALA48 |
| A | LYS244 |
| A | LYS272 |
| A | ALA273 |
| A | LEU274 |
| A | THR276 |
| A | ALA278 |
| A | SER279 |
| A | PHE285 |
| A | NA1002 |
| A | HOH1150 |
| A | SER49 |
| A | HOH1166 |
| A | HOH1167 |
| A | HOH1192 |
| A | HOH1253 |
| A | HOH1258 |
| A | SER50 |
| A | GLY51 |
| A | PHE52 |
| A | SER73 |
| A | TYR74 |
| A | GLU75 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 1002 |
| Chain | Residue |
| A | GLY47 |
| A | SER50 |
| A | PHE52 |
| A | GLY53 |
| A | SER138 |
| A | NAI1001 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"HAMAP-Rule","id":"MF_01838","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23050861","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"23050861","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Site: {"description":"Plays an important role in discriminating NADH against NADPH","evidences":[{"source":"PubMed","id":"23050861","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
