4EU6
Succinyl-CoA:acetate CoA-transferase (AarCH6) in complex with CoA, acetate, and covalent acetylglutamyl anhydride and glutamyl-CoA thioester adducts
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003986 | molecular_function | acetyl-CoA hydrolase activity |
| A | 0006083 | biological_process | acetate metabolic process |
| A | 0006084 | biological_process | acetyl-CoA metabolic process |
| A | 0006085 | biological_process | acetyl-CoA biosynthetic process |
| A | 0008410 | molecular_function | CoA-transferase activity |
| A | 0008775 | molecular_function | acetate CoA-transferase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0019427 | biological_process | acetyl-CoA biosynthetic process from acetate |
| A | 0045733 | biological_process | acetate catabolic process |
| A | 1901289 | biological_process | succinyl-CoA catabolic process |
| B | 0003986 | molecular_function | acetyl-CoA hydrolase activity |
| B | 0006083 | biological_process | acetate metabolic process |
| B | 0006084 | biological_process | acetyl-CoA metabolic process |
| B | 0006085 | biological_process | acetyl-CoA biosynthetic process |
| B | 0008410 | molecular_function | CoA-transferase activity |
| B | 0008775 | molecular_function | acetate CoA-transferase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0019427 | biological_process | acetyl-CoA biosynthetic process from acetate |
| B | 0045733 | biological_process | acetate catabolic process |
| B | 1901289 | biological_process | succinyl-CoA catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 35 |
| Details | BINDING SITE FOR RESIDUE COA A 2598 |
| Chain | Residue |
| A | GLN267 |
| A | MET363 |
| A | ILE364 |
| A | ASN384 |
| A | GLY385 |
| A | ILE386 |
| A | SER389 |
| A | ALA407 |
| A | ILE412 |
| A | HOH517 |
| A | HOH524 |
| A | GLY269 |
| A | HOH530 |
| A | HOH561 |
| A | HOH576 |
| A | HOH589 |
| A | HOH598 |
| A | HOH617 |
| A | HOH635 |
| A | HOH822 |
| A | HOH878 |
| A | HOH898 |
| A | VAL270 |
| A | HOH933 |
| A | HOH1029 |
| A | HOH1056 |
| A | ACT1428 |
| B | GLU237 |
| B | LYS240 |
| A | GLY271 |
| A | ASN272 |
| A | VAL273 |
| A | GLU294 |
| A | ASN361 |
| A | GLY362 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 515 |
| Chain | Residue |
| A | ASN112 |
| A | ARG120 |
| A | ASN125 |
| B | GLY443 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 516 |
| Chain | Residue |
| A | VAL196 |
| A | ARG354 |
| A | HOH844 |
| B | ARG354 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE ACT A 1428 |
| Chain | Residue |
| A | THR36 |
| A | PHE92 |
| A | LEU114 |
| A | VAL270 |
| A | GLU294 |
| A | GLY387 |
| A | GLY388 |
| A | COA2598 |
| site_id | AC5 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE COA B 2598 |
| Chain | Residue |
| B | GLN267 |
| B | VAL270 |
| B | GLY271 |
| B | ASN272 |
| B | VAL273 |
| B | GLU294 |
| B | ASN361 |
| B | MET363 |
| B | ILE364 |
| B | ASN384 |
| B | GLY385 |
| B | ILE386 |
| B | SER389 |
| B | LYS408 |
| B | ILE412 |
| B | HOH518 |
| B | HOH593 |
| B | HOH600 |
| B | HOH623 |
| B | HOH685 |
| B | HOH688 |
| B | HOH885 |
| B | HOH901 |
| B | HOH963 |
| B | HOH1031 |
| B | HOH1032 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 515 |
| Chain | Residue |
| A | GLY443 |
| B | ASN112 |
| B | ARG120 |
| B | ASN125 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 516 |
| Chain | Residue |
| A | ARG354 |
| B | VAL196 |
| B | ARG354 |
| B | HOH865 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT B 1428 |
| Chain | Residue |
| B | THR36 |
| B | SER71 |
| B | THR94 |
| B | ARG228 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"5-glutamyl coenzyme A thioester intermediate","evidences":[{"source":"PubMed","id":"23030530","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"23030530","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
