4ES5

Crystal structure of the cap-binding domain of polymerase basic protein 2 from influenza virus A/Bar-headed Gs/Qinghai/15c/2005 (h5n1) with bound m7GTP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0039694	biological_process	viral RNA genome replication
B	0003723	molecular_function	RNA binding
B	0039694	biological_process	viral RNA genome replication
C	0003723	molecular_function	RNA binding
C	0039694	biological_process	viral RNA genome replication
D	0003723	molecular_function	RNA binding
D	0039694	biological_process	viral RNA genome replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE MGT A 501

Chain	Residue
A	PHE323
A	HIS432
A	HOH699
A	HOH702
A	HOH720
A	HOH740
A	HOH852
A	HOH861
A	HIS357
A	GLU361
A	PHE363
A	LYS376
A	PHE404
A	GLN406
A	ASN429
A	MET431

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site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 A 502

Chain	Residue
A	SER324
A	PHE325
A	GLY326
A	GLY327
A	HIS432
A	HOH647
A	HOH751
A	HOH760
A	HOH766

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site_id	AC3
Number of Residues	16
Details	BINDING SITE FOR RESIDUE MGT B 501

Chain	Residue
B	PHE323
B	ARG332
B	HIS357
B	GLU361
B	PHE363
B	LYS376
B	PHE404
B	ASN429
B	MET431
B	HIS432
B	HOH608
B	HOH635
B	HOH698
B	HOH736
D	ARG355
D	MGT501

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site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 B 502

Chain	Residue
B	SER324
B	PHE325
B	GLY326
B	GLY327
B	HIS432
B	HOH675
B	HOH775

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site_id	AC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE MGT C 501

Chain	Residue
C	PHE323
C	ARG355
C	HIS357
C	GLU361
C	PHE363
C	LYS376
C	PHE404
C	ASN429
C	MET431

---

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 C 502

Chain	Residue
C	SER324
C	PHE325
C	GLY326
C	GLY327
C	HIS432
C	HOH658
D	ARG423
D	HOH615

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site_id	AC7
Number of Residues	11
Details	BINDING SITE FOR RESIDUE MGT D 501

Chain	Residue
B	MGT501
D	PHE323
D	HIS357
D	GLU361
D	PHE363
D	LYS376
D	PHE404
D	GLN406
D	ASN429
D	MET431
D	HIS432

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site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D 502

Chain	Residue
D	PHE325
D	GLY326
D	GLY327
D	HIS432
D	HOH616

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