4ER7

Crystal Structure of human DOT1L in complex with inhibitor SGC0947

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0031151	molecular_function	histone H3K79 methyltransferase activity
A	0051726	biological_process	regulation of cell cycle

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE AW3 A 501

Chain	Residue
A	ASP161
A	PHE239
A	ASN241
A	SER268
A	HOH651
A	GLY163
A	SER164
A	VAL169
A	GLU186
A	LYS187
A	GLY221
A	ASP222
A	PHE223

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 502

Chain	Residue
A	ALA18
A	VAL19
A	TYR20
A	HIS117
A	LYS204
A	HOH650

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING:

Chain	Residue	Details
A	TYR136
A	PHE159
A	GLU186
A	ASP222

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER297

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER374

---