4ER7
Crystal Structure of human DOT1L in complex with inhibitor SGC0947
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE AW3 A 501 |
| Chain | Residue |
| A | ASP161 |
| A | PHE239 |
| A | ASN241 |
| A | SER268 |
| A | HOH651 |
| A | GLY163 |
| A | SER164 |
| A | VAL169 |
| A | GLU186 |
| A | LYS187 |
| A | GLY221 |
| A | ASP222 |
| A | PHE223 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 502 |
| Chain | Residue |
| A | ALA18 |
| A | VAL19 |
| A | TYR20 |
| A | HIS117 |
| A | LYS204 |
| A | HOH650 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12628190","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1NW3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00902","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12628190","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1NW3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
