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4ER7

Crystal Structure of human DOT1L in complex with inhibitor SGC0947

Functional Information from GO Data
ChainGOidnamespacecontents
A0031151molecular_functionhistone H3K79 methyltransferase activity
A0051726biological_processregulation of cell cycle
Functional Information from PDB Data
site_idAC1
Number of Residues13
DetailsBINDING SITE FOR RESIDUE AW3 A 501
ChainResidue
AASP161
APHE239
AASN241
ASER268
AHOH651
AGLY163
ASER164
AVAL169
AGLU186
ALYS187
AGLY221
AASP222
APHE223

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE GOL A 502
ChainResidue
AALA18
AVAL19
ATYR20
AHIS117
ALYS204
AHOH650

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues11
DetailsBinding site: {}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

243911

PDB entries from 2025-10-29

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