4ER6

Crystal structure of human DOT1L in complex with inhibitor SGC0946

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0031151	molecular_function	histone H3K79 methyltransferase activity
A	0051726	biological_process	regulation of cell cycle

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE BR A 501

Chain	Residue
A	AW2502

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site_id	AC2
Number of Residues	19
Details	BINDING SITE FOR RESIDUE AW2 A 502

Chain	Residue
A	ALA188
A	GLY221
A	ASP222
A	PHE223
A	PHE239
A	ASN241
A	PHE245
A	VAL267
A	SER268
A	TYR312
A	TYR58
A	BR501
A	ASP161
A	GLY163
A	SER164
A	GLY165
A	VAL169
A	GLU186
A	LYS187

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site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE NA A 503

Chain	Residue
A	LYS52
A	LEU53
A	MET55
A	ASN57
A	ARG335
A	HOH624
A	HOH625

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING:

Chain	Residue	Details
A	TYR136
A	PHE159
A	GLU186
A	ASP222

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER297

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER374

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