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4ER6

Crystal structure of human DOT1L in complex with inhibitor SGC0946

Functional Information from GO Data
ChainGOidnamespacecontents
A0031151molecular_functionhistone H3K79 methyltransferase activity
A0051726biological_processregulation of cell cycle
Functional Information from PDB Data
site_idAC1
Number of Residues1
DetailsBINDING SITE FOR RESIDUE BR A 501
ChainResidue
AAW2502

site_idAC2
Number of Residues19
DetailsBINDING SITE FOR RESIDUE AW2 A 502
ChainResidue
AALA188
AGLY221
AASP222
APHE223
APHE239
AASN241
APHE245
AVAL267
ASER268
ATYR312
ATYR58
ABR501
AASP161
AGLY163
ASER164
AGLY165
AVAL169
AGLU186
ALYS187

site_idAC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE NA A 503
ChainResidue
ALYS52
ALEU53
AMET55
AASN57
AARG335
AHOH624
AHOH625

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues14
DetailsBinding site: {}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

243911

PDB entries from 2025-10-29

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