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4EQE

Crystal structure of histidine triad nucleotide-binding protein 1 (HINT1) from human complexed with Lys-AMS

Functional Information from GO Data
ChainGOidnamespacecontents
A0000118cellular_componenthistone deacetylase complex
A0000166molecular_functionnucleotide binding
A0003824molecular_functioncatalytic activity
A0005080molecular_functionprotein kinase C binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0006355biological_processregulation of DNA-templated transcription
A0006508biological_processproteolysis
A0006915biological_processapoptotic process
A0007165biological_processsignal transduction
A0008234molecular_functioncysteine-type peptidase activity
A0009154biological_processpurine ribonucleotide catabolic process
A0016787molecular_functionhydrolase activity
A0016926biological_processprotein desumoylation
A0016929molecular_functiondeSUMOylase activity
A0043530molecular_functionadenosine 5'-monophosphoramidase activity
A0050850biological_processpositive regulation of calcium-mediated signaling
A0070062cellular_componentextracellular exosome
A0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
B0000118cellular_componenthistone deacetylase complex
B0000166molecular_functionnucleotide binding
B0003824molecular_functioncatalytic activity
B0005080molecular_functionprotein kinase C binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005886cellular_componentplasma membrane
B0006355biological_processregulation of DNA-templated transcription
B0006508biological_processproteolysis
B0006915biological_processapoptotic process
B0007165biological_processsignal transduction
B0008234molecular_functioncysteine-type peptidase activity
B0009154biological_processpurine ribonucleotide catabolic process
B0016787molecular_functionhydrolase activity
B0016926biological_processprotein desumoylation
B0016929molecular_functiondeSUMOylase activity
B0043530molecular_functionadenosine 5'-monophosphoramidase activity
B0050850biological_processpositive regulation of calcium-mediated signaling
B0070062cellular_componentextracellular exosome
B0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
Functional Information from PDB Data
site_idAC1
Number of Residues7
DetailsBINDING SITE FOR RESIDUE EPE B 201
ChainResidue
BTHR17
BTHR17
BILE18
BILE18
BSER107
BHOH410
BHOH410

site_idAC2
Number of Residues22
DetailsBINDING SITE FOR RESIDUE KAA B 202
ChainResidue
BILE18
BPHE19
BHIS42
BASP43
BILE44
BSER45
BLEU53
BASN99
BGLY105
BSER107
BVAL108
BHIS112
BHIS114
BHOH312
BHOH339
BHOH353
BHOH359
BHOH407
BHOH414
BHOH415
ATRP123
AHOH337

Functional Information from PROSITE/UniProt
site_idPS00892
Number of Residues19
DetailsHIT_1 HIT domain signature. NegsdGgQsVyHVHLHVLG
ChainResidueDetails
AASN99-GLY117

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Tele-AMP-histidine intermediate => ECO:0000269|PubMed:9323207
ChainResidueDetails
AHIS112
BHIS112

site_idSWS_FT_FI2
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:22869114, ECO:0007744|PDB:3TW2
ChainResidueDetails
AASP43
AASN99
AGLY105
AHIS112
BASP43
BASN99
BGLY105
BHIS112

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: N-acetylalanine => ECO:0007744|PubMed:22814378
ChainResidueDetails
AALA2
BALA2

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS21
ALYS30
BLYS21
BLYS30

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P70349
ChainResidueDetails
ASER45
ASER72
BSER45
BSER72

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PDB entries from 2024-10-30

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