4ENJ

Crystal structure of S. pombe Atl1 in complex with damaged DNA containing O6-hydroxyethylguanine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003684	molecular_function	damaged DNA binding
A	0003824	molecular_function	catalytic activity
A	0003908	molecular_function	methylated-DNA-[protein]-cysteine S-methyltransferase activity
A	0005634	cellular_component	nucleus
A	0005829	cellular_component	cytosol
A	0006259	biological_process	DNA metabolic process
A	0006281	biological_process	DNA repair
A	0006283	biological_process	transcription-coupled nucleotide-excision repair
A	0032132	molecular_function	O6-alkylguanine-DNA binding
A	0070911	biological_process	global genome nucleotide-excision repair

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Required for phosphate rotation/nucleotide flipping => ECO:0000305|PubMed:19516334

Chain	Residue	Details
A	TYR25

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site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Arg finger, required for nucleotide flipping => ECO:0000305|PubMed:19516334

Chain	Residue	Details
A	ARG39

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Critical for recognition of O(6)-alkylguanines, probes the electrostatic potential of the flipped base to distinguish between O(6)-alkylguanine and guanine => ECO:0000269|PubMed:23112169

Chain	Residue	Details
A	ARG69

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