Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4EM6

The structure of Glucose-6-phosphate isomerase (GPI) from Brucella melitensis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004347	molecular_function	glucose-6-phosphate isomerase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006094	biological_process	gluconeogenesis
A	0006096	biological_process	glycolytic process
A	0016853	molecular_function	isomerase activity
A	0048029	molecular_function	monosaccharide binding
A	0051156	biological_process	glucose 6-phosphate metabolic process
A	0097367	molecular_function	carbohydrate derivative binding
A	1901135	biological_process	carbohydrate derivative metabolic process
B	0004347	molecular_function	glucose-6-phosphate isomerase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006094	biological_process	gluconeogenesis
B	0006096	biological_process	glycolytic process
B	0016853	molecular_function	isomerase activity
B	0048029	molecular_function	monosaccharide binding
B	0051156	biological_process	glucose 6-phosphate metabolic process
B	0097367	molecular_function	carbohydrate derivative binding
B	1901135	biological_process	carbohydrate derivative metabolic process
C	0004347	molecular_function	glucose-6-phosphate isomerase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006094	biological_process	gluconeogenesis
C	0006096	biological_process	glycolytic process
C	0016853	molecular_function	isomerase activity
C	0048029	molecular_function	monosaccharide binding
C	0051156	biological_process	glucose 6-phosphate metabolic process
C	0097367	molecular_function	carbohydrate derivative binding
C	1901135	biological_process	carbohydrate derivative metabolic process
D	0004347	molecular_function	glucose-6-phosphate isomerase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006094	biological_process	gluconeogenesis
D	0006096	biological_process	glycolytic process
D	0016853	molecular_function	isomerase activity
D	0048029	molecular_function	monosaccharide binding
D	0051156	biological_process	glucose 6-phosphate metabolic process
D	0097367	molecular_function	carbohydrate derivative binding
D	1901135	biological_process	carbohydrate derivative metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL D 601

Chain	Residue
D	ALA244
D	LEU245
D	ASP246
D	LYS247
D	HOH1286

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA D 602

Chain	Residue
D	HOH1245
D	HOH1260
D	HOH1288
B	HOH1139
D	GLY327
D	HOH822
D	HOH1216

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA A 601

Chain	Residue
A	GLY531
A	HOH1351
A	HOH1352
A	HOH1353
A	HOH1354
A	HOH1355
A	HOH1356

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 602

Chain	Residue
A	GLY156
A	GLN349
A	HOH1008
A	HOH1224

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 603

Chain	Residue
A	PRO197
A	ALA198
A	HOH943
A	HOH1055

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL B 601

Chain	Residue
B	ARG440
B	GLU454
B	HOH1355

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA B 602

Chain	Residue
A	HOH868
A	HOH935
A	HOH1065
B	GLY531
B	HOH792
B	HOH858
D	HOH844

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL B 603

Chain	Residue
B	GLY156
B	GLN349
B	HOH1091

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA B 604

Chain	Residue
B	ALA169
B	HIS172
B	HOH1351
B	HOH1360
D	HOH1256

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO C 601

Chain	Residue
A	HOH1132
C	HOH812

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL C 602

Chain	Residue
C	ALA244
C	LEU245
C	ASP246
C	LYS247

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA C 603

Chain	Residue
C	ALA33
C	ASP246
C	HOH1261
C	HOH1304

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA C 604

Chain	Residue
C	ASP362
C	HOH1305
C	HOH1306
C	HOH1307
C	HOH1309

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 605

Chain	Residue
C	ALA169
C	HIS172
C	HOH1188
C	HOH1296
C	HOH1314
C	HOH1315

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL C 606

Chain	Residue
B	GLU231
B	ALA232
C	ARG144
C	LYS145
C	HOH805

site_id	BC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL C 607

Chain	Residue
C	GLY156
C	GLN349
C	HOH1102

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA C 608

Chain	Residue
C	GLY327
C	HOH932
C	HOH1009
C	HOH1287

site_id	BC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL C 609

Chain	Residue
A	HOH745
C	GLY329
C	HOH799
C	HOH1150

Functional Information from PROSITE/UniProt

site_id	PS00174
Number of Residues	18
Details	P_GLUCOSE_ISOMERASE_2 Phosphoglucose isomerase signature 2. AqIFginaFDQwGVElgK

Chain	Residue	Details
D	ALA496-LYS513

site_id	PS00765
Number of Residues	14
Details	P_GLUCOSE_ISOMERASE_1 Phosphoglucose isomerase signature 1. DwVGGRYSVwSAIG

Chain	Residue	Details
D	ASP263-GLY276

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton donor => ECO:0000255\|HAMAP-Rule:MF_00473

Chain	Residue	Details
D	GLU353
A	GLU353
B	GLU353
C	GLU353

site_id	SWS_FT_FI2
Number of Residues	8
Details	ACT_SITE: ACT_SITE => ECO:0000255\|HAMAP-Rule:MF_00473

Chain	Residue	Details
D	HIS384
D	LYS513
A	HIS384
A	LYS513
B	HIS384
B	LYS513
C	HIS384
C	LYS513

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)