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4EL1

Crystal structure of oxidized hPDI (abb'xa')

Functional Information from GO Data
ChainGOidnamespacecontents
A0003723molecular_functionRNA binding
A0003756molecular_functionprotein disulfide isomerase activity
A0003779molecular_functionactin binding
A0004656molecular_functionprocollagen-proline 4-dioxygenase activity
A0005178molecular_functionintegrin binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005783cellular_componentendoplasmic reticulum
A0005788cellular_componentendoplasmic reticulum lumen
A0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0005925cellular_componentfocal adhesion
A0006457biological_processprotein folding
A0006888biological_processendoplasmic reticulum to Golgi vesicle-mediated transport
A0009897cellular_componentexternal side of plasma membrane
A0015035molecular_functionprotein-disulfide reductase activity
A0016020cellular_componentmembrane
A0016222cellular_componentprocollagen-proline 4-dioxygenase complex
A0016853molecular_functionisomerase activity
A0016972molecular_functionthiol oxidase activity
A0018401biological_processpeptidyl-proline hydroxylation to 4-hydroxy-L-proline
A0019899molecular_functionenzyme binding
A0030027cellular_componentlamellipodium
A0030070biological_processinsulin processing
A0032991cellular_componentprotein-containing complex
A0034663cellular_componentendoplasmic reticulum chaperone complex
A0034975biological_processprotein folding in endoplasmic reticulum
A0034976biological_processresponse to endoplasmic reticulum stress
A0035722biological_processinterleukin-12-mediated signaling pathway
A0038155biological_processinterleukin-23-mediated signaling pathway
A0042470cellular_componentmelanosome
A0044877molecular_functionprotein-containing complex binding
A0045785biological_processpositive regulation of cell adhesion
A0046598biological_processpositive regulation of viral entry into host cell
A0046982molecular_functionprotein heterodimerization activity
A0070062cellular_componentextracellular exosome
A0071456biological_processcellular response to hypoxia
A0098761biological_processcellular response to interleukin-7
A1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
A1902175biological_processregulation of oxidative stress-induced intrinsic apoptotic signaling pathway
B0003723molecular_functionRNA binding
B0003756molecular_functionprotein disulfide isomerase activity
B0003779molecular_functionactin binding
B0004656molecular_functionprocollagen-proline 4-dioxygenase activity
B0005178molecular_functionintegrin binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005783cellular_componentendoplasmic reticulum
B0005788cellular_componentendoplasmic reticulum lumen
B0005793cellular_componentendoplasmic reticulum-Golgi intermediate compartment
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005886cellular_componentplasma membrane
B0005925cellular_componentfocal adhesion
B0006457biological_processprotein folding
B0006888biological_processendoplasmic reticulum to Golgi vesicle-mediated transport
B0009897cellular_componentexternal side of plasma membrane
B0015035molecular_functionprotein-disulfide reductase activity
B0016020cellular_componentmembrane
B0016222cellular_componentprocollagen-proline 4-dioxygenase complex
B0016853molecular_functionisomerase activity
B0016972molecular_functionthiol oxidase activity
B0018401biological_processpeptidyl-proline hydroxylation to 4-hydroxy-L-proline
B0019899molecular_functionenzyme binding
B0030027cellular_componentlamellipodium
B0030070biological_processinsulin processing
B0032991cellular_componentprotein-containing complex
B0034663cellular_componentendoplasmic reticulum chaperone complex
B0034975biological_processprotein folding in endoplasmic reticulum
B0034976biological_processresponse to endoplasmic reticulum stress
B0035722biological_processinterleukin-12-mediated signaling pathway
B0038155biological_processinterleukin-23-mediated signaling pathway
B0042470cellular_componentmelanosome
B0044877molecular_functionprotein-containing complex binding
B0045785biological_processpositive regulation of cell adhesion
B0046598biological_processpositive regulation of viral entry into host cell
B0046982molecular_functionprotein heterodimerization activity
B0070062cellular_componentextracellular exosome
B0071456biological_processcellular response to hypoxia
B0098761biological_processcellular response to interleukin-7
B1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
B1902175biological_processregulation of oxidative stress-induced intrinsic apoptotic signaling pathway
Functional Information from PROSITE/UniProt
site_idPS00194
Number of Residues19
DetailsTHIOREDOXIN_1 Thioredoxin family active site. LVeFYapWCGHCKaLapeY
ChainResidueDetails
ALEU45-TYR63
APHE389-TRP407

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Nucleophile
ChainResidueDetails
ACYS53
ACYS56
BCYS53
BCYS56

site_idSWS_FT_FI2
Number of Residues4
DetailsACT_SITE: Nucleophile => ECO:0000250
ChainResidueDetails
ACYS397
ACYS400
BCYS397
BCYS400

site_idSWS_FT_FI3
Number of Residues4
DetailsSITE: Contributes to redox potential value
ChainResidueDetails
AGLY54
AHIS55
BGLY54
BHIS55

site_idSWS_FT_FI4
Number of Residues2
DetailsSITE: Lowers pKa of C-terminal Cys of first active site
ChainResidueDetails
AARG120
BARG120

site_idSWS_FT_FI5
Number of Residues4
DetailsSITE: Contributes to redox potential value => ECO:0000250
ChainResidueDetails
AGLY398
AHIS399
BGLY398
BHIS399

site_idSWS_FT_FI6
Number of Residues2
DetailsSITE: Lowers pKa of C-terminal Cys of second active site => ECO:0000250
ChainResidueDetails
AARG461
BARG461

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P09103
ChainResidueDetails
ALYS200
BLYS200

site_idSWS_FT_FI8
Number of Residues4
DetailsMOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P09103
ChainResidueDetails
ALYS222
ALYS271
BLYS222
BLYS271

site_idSWS_FT_FI9
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:32149426
ChainResidueDetails
ASER331
ASER427
BSER331
BSER427

site_idSWS_FT_FI10
Number of Residues2
DetailsMOD_RES: Phosphoserine; by FAM20C => ECO:0000269|PubMed:26091039, ECO:0000269|PubMed:32149426
ChainResidueDetails
ASER357
BSER357

Catalytic Information from CSA
site_idMCSA1
Number of Residues4
DetailsM-CSA 191
ChainResidueDetails
ACYS53nucleofuge, nucleophile, proton acceptor, proton donor
AGLY54activator, modifies pKa
AHIS55modifies pKa, proton acceptor, proton donor
ACYS56

site_idMCSA2
Number of Residues4
DetailsM-CSA 191
ChainResidueDetails
BCYS53nucleofuge, nucleophile, proton acceptor, proton donor
BGLY54activator, modifies pKa
BHIS55modifies pKa, proton acceptor, proton donor
BCYS56

218853

PDB entries from 2024-04-24

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