4EKP
T4 Lysozyme L99A/M102H with Nitrobenzene Bound
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003796 | molecular_function | lysozyme activity |
| A | 0009253 | biological_process | peptidoglycan catabolic process |
| A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| A | 0016998 | biological_process | cell wall macromolecule catabolic process |
| A | 0030430 | cellular_component | host cell cytoplasm |
| A | 0031640 | biological_process | killing of cells of another organism |
| A | 0042742 | biological_process | defense response to bacterium |
| A | 0044659 | biological_process | viral release from host cell by cytolysis |
| B | 0003796 | molecular_function | lysozyme activity |
| B | 0009253 | biological_process | peptidoglycan catabolic process |
| B | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| B | 0016998 | biological_process | cell wall macromolecule catabolic process |
| B | 0030430 | cellular_component | host cell cytoplasm |
| B | 0031640 | biological_process | killing of cells of another organism |
| B | 0042742 | biological_process | defense response to bacterium |
| B | 0044659 | biological_process | viral release from host cell by cytolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE BME A 201 |
| Chain | Residue |
| A | ILE3 |
| A | TYR88 |
| A | ALA93 |
| A | ARG96 |
| A | CYS97 |
| A | ILE100 |
| A | HOH351 |
| A | HOH436 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE NBZ A 202 |
| Chain | Residue |
| A | LEU84 |
| A | VAL87 |
| A | TYR88 |
| A | ALA99 |
| A | HIS102 |
| A | VAL111 |
| A | LEU118 |
| A | LEU121 |
| A | PHE153 |
| A | ILE78 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 203 |
| Chain | Residue |
| A | ARG14 |
| A | LEU15 |
| A | LYS16 |
| A | HOH319 |
| A | HOH423 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 204 |
| Chain | Residue |
| A | ARG76 |
| A | ARG80 |
| A | HOH414 |
| B | LYS135 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 205 |
| Chain | Residue |
| A | ARG119 |
| A | ARG125 |
| B | LYS48 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT A 206 |
| Chain | Residue |
| A | GLU5 |
| A | HOH468 |
| B | HOH402 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE BME A 207 |
| Chain | Residue |
| A | PHE-3 |
| A | TYR161 |
| A | HOH308 |
| A | HOH470 |
| B | ASN55 |
| B | HOH336 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT A 208 |
| Chain | Residue |
| A | LYS135 |
| B | ARG76 |
| B | ARG80 |
| B | SO4203 |
| B | HOH392 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE BME B 201 |
| Chain | Residue |
| B | ILE3 |
| B | CYS97 |
| B | HOH351 |
| site_id | BC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE NBZ B 202 |
| Chain | Residue |
| B | ILE78 |
| B | LEU84 |
| B | VAL87 |
| B | TYR88 |
| B | ALA99 |
| B | HIS102 |
| B | VAL111 |
| B | LEU121 |
| B | PHE153 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 203 |
| Chain | Residue |
| A | ACT208 |
| B | ARG76 |
| B | ARG80 |
| B | HOH346 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 204 |
| Chain | Residue |
| B | ARG119 |
| B | MET120 |
| B | ARG125 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT B 205 |
| Chain | Residue |
| B | LEU15 |
| B | LYS16 |
| B | HOH433 |
| site_id | BC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE BME B 206 |
| Chain | Residue |
| B | GLY30 |
| B | LEU32 |
| B | ASP70 |
| B | PHE104 |
| B | HOH331 |
| B | HOH343 |
| B | HOH450 |
| site_id | BC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE HED B 207 |
| Chain | Residue |
| A | THR109 |
| A | HOH367 |
| B | ALA130 |
| B | THR151 |
| B | ARG154 |
| B | HOH368 |
| B | HOH432 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098 |
| Chain | Residue | Details |
| B | GLU11 | |
| A | GLU11 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:1892846, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098 |
| Chain | Residue | Details |
| A | ASP20 | |
| B | ASP20 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:8266098 |
| Chain | Residue | Details |
| A | LEU32 | |
| A | PHE104 | |
| B | LEU32 | |
| B | PHE104 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000303|PubMed:7831309 |
| Chain | Residue | Details |
| A | VAL117 | |
| A | ASN132 | |
| B | VAL117 | |
| B | ASN132 |
