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4EJN

Crystal structure of autoinhibited form of AKT1 in complex with N-(4-(5-(3-acetamidophenyl)-2-(2-aminopyridin-3-yl)-3H-imidazo[4,5-b]pyridin-3-yl)benzyl)-3-fluorobenzamide

Functional Information from GO Data
ChainGOidnamespacecontents
A0001649biological_processosteoblast differentiation
A0001893biological_processmaternal placenta development
A0001934biological_processpositive regulation of protein phosphorylation
A0001938biological_processpositive regulation of endothelial cell proliferation
A0002042biological_processcell migration involved in sprouting angiogenesis
A0003376biological_processsphingosine-1-phosphate receptor signaling pathway
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004676molecular_function3-phosphoinositide-dependent protein kinase activity
A0004677molecular_functionDNA-dependent protein kinase activity
A0004679molecular_functionAMP-activated protein kinase activity
A0004694molecular_functioneukaryotic translation initiation factor 2alpha kinase activity
A0004711molecular_functionribosomal protein S6 kinase activity
A0004712molecular_functionprotein serine/threonine/tyrosine kinase activity
A0005515molecular_functionprotein binding
A0005516molecular_functioncalmodulin binding
A0005524molecular_functionATP binding
A0005547molecular_functionphosphatidylinositol-3,4,5-trisphosphate binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005758cellular_componentmitochondrial intermembrane space
A0005819cellular_componentspindle
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005911cellular_componentcell-cell junction
A0005938cellular_componentcell cortex
A0005977biological_processglycogen metabolic process
A0005978biological_processglycogen biosynthetic process
A0005979biological_processregulation of glycogen biosynthetic process
A0006006biological_processglucose metabolic process
A0006338biological_processchromatin remodeling
A0006417biological_processregulation of translation
A0006468biological_processprotein phosphorylation
A0006469biological_processnegative regulation of protein kinase activity
A0006606biological_processprotein import into nucleus
A0006809biological_processnitric oxide biosynthetic process
A0006915biological_processapoptotic process
A0006924biological_processactivation-induced cell death of T cells
A0006954biological_processinflammatory response
A0006979biological_processresponse to oxidative stress
A0007165biological_processsignal transduction
A0007173biological_processepidermal growth factor receptor signaling pathway
A0007186biological_processG protein-coupled receptor signaling pathway
A0007281biological_processgerm cell development
A0007399biological_processnervous system development
A0008283biological_processcell population proliferation
A0008286biological_processinsulin receptor signaling pathway
A0008637biological_processapoptotic mitochondrial changes
A0009408biological_processresponse to heat
A0009725biological_processresponse to hormone
A0010467biological_processgene expression
A0010507biological_processnegative regulation of autophagy
A0010595biological_processpositive regulation of endothelial cell migration
A0010628biological_processpositive regulation of gene expression
A0010629biological_processnegative regulation of gene expression
A0010748biological_processnegative regulation of long-chain fatty acid import across plasma membrane
A0010761biological_processfibroblast migration
A0010763biological_processpositive regulation of fibroblast migration
A0010765biological_processpositive regulation of sodium ion transport
A0010907biological_processpositive regulation of glucose metabolic process
A0010951biological_processnegative regulation of endopeptidase activity
A0010975biological_processregulation of neuron projection development
A0015630cellular_componentmicrotubule cytoskeleton
A0016020cellular_componentmembrane
A0016242biological_processnegative regulation of macroautophagy
A0016301molecular_functionkinase activity
A0016310biological_processphosphorylation
A0016567biological_processprotein ubiquitination
A0018105biological_processpeptidyl-serine phosphorylation
A0018107biological_processpeptidyl-threonine phosphorylation
A0019049biological_processvirus-mediated perturbation of host defense response
A0019221biological_processcytokine-mediated signaling pathway
A0019899molecular_functionenzyme binding
A0019901molecular_functionprotein kinase binding
A0022605biological_processmammalian oogenesis stage
A0030027cellular_componentlamellipodium
A0030154biological_processcell differentiation
A0030163biological_processprotein catabolic process
A0030235molecular_functionnitric-oxide synthase regulator activity
A0030291molecular_functionprotein serine/threonine kinase inhibitor activity
A0030307biological_processpositive regulation of cell growth
A0030334biological_processregulation of cell migration
A0030335biological_processpositive regulation of cell migration
A0031295biological_processT cell costimulation
A0031397biological_processnegative regulation of protein ubiquitination
A0031641biological_processregulation of myelination
A0031663biological_processlipopolysaccharide-mediated signaling pathway
A0031929biological_processTOR signaling
A0031982cellular_componentvesicle
A0031999biological_processnegative regulation of fatty acid beta-oxidation
A0032079biological_processpositive regulation of endodeoxyribonuclease activity
A0032091biological_processnegative regulation of protein binding
A0032094biological_processresponse to food
A0032287biological_processperipheral nervous system myelin maintenance
A0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
A0032869biological_processcellular response to insulin stimulus
A0032880biological_processregulation of protein localization
A0032991cellular_componentprotein-containing complex
A0033138biological_processpositive regulation of peptidyl-serine phosphorylation
A0034405biological_processresponse to fluid shear stress
A0035175molecular_functionhistone H3S10 kinase activity
A0035402molecular_functionhistone H3T11 kinase activity
A0035403molecular_functionhistone H3T6 kinase activity
A0035556biological_processintracellular signal transduction
A0035655biological_processinterleukin-18-mediated signaling pathway
A0035924biological_processcellular response to vascular endothelial growth factor stimulus
A0035979molecular_functionhistone H2AXS139 kinase activity
A0036064cellular_componentciliary basal body
A0036294biological_processcellular response to decreased oxygen levels
A0042593biological_processglucose homeostasis
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0042981biological_processregulation of apoptotic process
A0043066biological_processnegative regulation of apoptotic process
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0043276biological_processanoikis
A0043325molecular_functionphosphatidylinositol-3,4-bisphosphate binding
A0043488biological_processregulation of mRNA stability
A0043491biological_processphosphatidylinositol 3-kinase/protein kinase B signal transduction
A0043536biological_processpositive regulation of blood vessel endothelial cell migration
A0044022molecular_functionhistone H3S28 kinase activity
A0044023molecular_functionhistone H4S1 kinase activity
A0044024molecular_functionhistone H2AS1 kinase activity
A0044025molecular_functionhistone H2BS14 kinase activity
A0045429biological_processpositive regulation of nitric oxide biosynthetic process
A0045600biological_processpositive regulation of fat cell differentiation
A0045725biological_processpositive regulation of glycogen biosynthetic process
A0045737biological_processpositive regulation of cyclin-dependent protein serine/threonine kinase activity
A0045746biological_processnegative regulation of Notch signaling pathway
A0045861biological_processnegative regulation of proteolysis
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046326biological_processpositive regulation of D-glucose import
A0046622biological_processpositive regulation of organ growth
A0046777biological_processprotein autophosphorylation
A0046889biological_processpositive regulation of lipid biosynthetic process
A0048009biological_processinsulin-like growth factor receptor signaling pathway
A0048266biological_processbehavioral response to pain
A0048661biological_processpositive regulation of smooth muscle cell proliferation
A0051000biological_processpositive regulation of nitric-oxide synthase activity
A0051091biological_processpositive regulation of DNA-binding transcription factor activity
A0051146biological_processstriated muscle cell differentiation
A0051247biological_processpositive regulation of protein metabolic process
A0060079biological_processexcitatory postsynaptic potential
A0060416biological_processresponse to growth hormone
A0060644biological_processmammary gland epithelial cell differentiation
A0060716biological_processlabyrinthine layer blood vessel development
A0070141biological_processresponse to UV-A
A0070848biological_processresponse to growth factor
A0071356biological_processcellular response to tumor necrosis factor
A0071363biological_processcellular response to growth factor stimulus
A0071364biological_processcellular response to epidermal growth factor stimulus
A0071380biological_processcellular response to prostaglandin E stimulus
A0071889molecular_function14-3-3 protein binding
A0071901biological_processnegative regulation of protein serine/threonine kinase activity
A0072354molecular_functionhistone H3T3 kinase activity
A0072371molecular_functionhistone H2AS121 kinase activity
A0072518molecular_functionRho-dependent protein serine/threonine kinase activity
A0072655biological_processestablishment of protein localization to mitochondrion
A0072656biological_processmaintenance of protein location in mitochondrion
A0072752biological_processcellular response to rapamycin
A0090201biological_processnegative regulation of release of cytochrome c from mitochondria
A0097011biological_processcellular response to granulocyte macrophage colony-stimulating factor stimulus
A0097194biological_processexecution phase of apoptosis
A0098794cellular_componentpostsynapse
A0098978cellular_componentglutamatergic synapse
A0099104molecular_functionpotassium channel activator activity
A0099175biological_processregulation of postsynapse organization
A0106310molecular_functionprotein serine kinase activity
A0110002biological_processregulation of tRNA methylation
A0140052biological_processcellular response to oxidised low-density lipoprotein particle stimulus
A0140823molecular_functionhistone H2BS36 kinase activity
A0140855molecular_functionhistone H3S57 kinase activity
A0140857molecular_functionhistone H3T45 kinase activity
A0150033biological_processnegative regulation of protein localization to lysosome
A0160049biological_processnegative regulation of cGAS/STING signaling pathway
A1900087biological_processpositive regulation of G1/S transition of mitotic cell cycle
A1900182biological_processpositive regulation of protein localization to nucleus
A1901653biological_processcellular response to peptide
A1901796biological_processregulation of signal transduction by p53 class mediator
A1902018biological_processnegative regulation of cilium assembly
A1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
A1903038biological_processnegative regulation of leukocyte cell-cell adhesion
A1903078biological_processpositive regulation of protein localization to plasma membrane
A1903318biological_processnegative regulation of protein maturation
A1903898biological_processnegative regulation of PERK-mediated unfolded protein response
A1904263biological_processpositive regulation of TORC1 signaling
A1905552biological_processpositive regulation of protein localization to endoplasmic reticulum
A1990090biological_processcellular response to nerve growth factor stimulus
A1990244molecular_functionhistone H2AT120 kinase activity
A1990418biological_processresponse to insulin-like growth factor stimulus
A2000010biological_processpositive regulation of protein localization to cell surface
A2000074biological_processregulation of type B pancreatic cell development
A2000117biological_processnegative regulation of cysteine-type endopeptidase activity
A2000402biological_processnegative regulation of lymphocyte migration
A2001240biological_processnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
A2001243biological_processnegative regulation of intrinsic apoptotic signaling pathway
Functional Information from PDB Data
site_idAC1
Number of Residues21
DetailsBINDING SITE FOR RESIDUE 0R4 A 501
ChainResidue
AASN53
AVAL270
AVAL271
ATYR272
AARG273
AASP274
AILE290
AASP292
ATYR326
AHOH603
AHOH635
AASN54
AHOH706
AHOH752
AGLN59
ALEU78
AGLN79
ATRP80
AILE84
ALEU210
ATHR211

site_idAC2
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SBT A 502
ChainResidue
ALYS163
AEDO503

site_idAC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE EDO A 503
ChainResidue
AMET147
AARG222
ASBT502

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues34
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGTFGKVIlVkekatgryyamkilkkevIVAK
ChainResidueDetails
ALEU156-LYS189

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VvYrDLKleNLML
ChainResidueDetails
AVAL270-LEU282

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027
ChainResidueDetails
AASP274

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:12176338, ECO:0000269|PubMed:12964941
ChainResidueDetails
ALYS14
AARG23
AASN53
AARG86

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
ALEU156
ALYS179

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:21775285
ChainResidueDetails
ALYS14
ALYS20

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648
ChainResidueDetails
ASER124

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphoserine; alternate => ECO:0007744|PubMed:18669648
ChainResidueDetails
ASER126

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphoserine; alternate => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER129

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphotyrosine; by TNK2 => ECO:0000269|PubMed:20333297
ChainResidueDetails
ATYR176

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by IKKE, PDPK1 and TBK1 => ECO:0000269|PubMed:15718470, ECO:0000269|PubMed:18456494, ECO:0000269|PubMed:20333297, ECO:0000269|PubMed:20481595, ECO:0000269|PubMed:21464307, ECO:0000269|PubMed:8978681, ECO:0000269|PubMed:9512493
ChainResidueDetails
ATHR308

site_idSWS_FT_FI10
Number of Residues2
DetailsCARBOHYD: O-linked (GlcNAc) serine; alternate => ECO:0000269|PubMed:22629392
ChainResidueDetails
ASER126
ASER129

site_idSWS_FT_FI11
Number of Residues2
DetailsCARBOHYD: O-linked (GlcNAc) threonine => ECO:0000269|PubMed:22629392
ChainResidueDetails
ATHR305
ATHR312

site_idSWS_FT_FI12
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:22410793
ChainResidueDetails
ALYS284

229183

PDB entries from 2024-12-18

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