4EJ0
Crystal structure of ADP-L-glycero-D-manno-heptose-6-epimerase from Burkholderia thailandensis
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0008712 | molecular_function | ADP-glyceromanno-heptose 6-epimerase activity |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0050661 | molecular_function | NADP binding |
| A | 0097171 | biological_process | ADP-L-glycero-beta-D-manno-heptose biosynthetic process |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0008712 | molecular_function | ADP-glyceromanno-heptose 6-epimerase activity |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0050661 | molecular_function | NADP binding |
| B | 0097171 | biological_process | ADP-L-glycero-beta-D-manno-heptose biosynthetic process |
| C | 0005975 | biological_process | carbohydrate metabolic process |
| C | 0008712 | molecular_function | ADP-glyceromanno-heptose 6-epimerase activity |
| C | 0016853 | molecular_function | isomerase activity |
| C | 0050661 | molecular_function | NADP binding |
| C | 0097171 | biological_process | ADP-L-glycero-beta-D-manno-heptose biosynthetic process |
| D | 0005975 | biological_process | carbohydrate metabolic process |
| D | 0008712 | molecular_function | ADP-glyceromanno-heptose 6-epimerase activity |
| D | 0016853 | molecular_function | isomerase activity |
| D | 0050661 | molecular_function | NADP binding |
| D | 0097171 | biological_process | ADP-L-glycero-beta-D-manno-heptose biosynthetic process |
| E | 0005975 | biological_process | carbohydrate metabolic process |
| E | 0008712 | molecular_function | ADP-glyceromanno-heptose 6-epimerase activity |
| E | 0016853 | molecular_function | isomerase activity |
| E | 0050661 | molecular_function | NADP binding |
| E | 0097171 | biological_process | ADP-L-glycero-beta-D-manno-heptose biosynthetic process |
| F | 0005975 | biological_process | carbohydrate metabolic process |
| F | 0008712 | molecular_function | ADP-glyceromanno-heptose 6-epimerase activity |
| F | 0016853 | molecular_function | isomerase activity |
| F | 0050661 | molecular_function | NADP binding |
| F | 0097171 | biological_process | ADP-L-glycero-beta-D-manno-heptose biosynthetic process |
| G | 0005975 | biological_process | carbohydrate metabolic process |
| G | 0008712 | molecular_function | ADP-glyceromanno-heptose 6-epimerase activity |
| G | 0016853 | molecular_function | isomerase activity |
| G | 0050661 | molecular_function | NADP binding |
| G | 0097171 | biological_process | ADP-L-glycero-beta-D-manno-heptose biosynthetic process |
| H | 0005975 | biological_process | carbohydrate metabolic process |
| H | 0008712 | molecular_function | ADP-glyceromanno-heptose 6-epimerase activity |
| H | 0016853 | molecular_function | isomerase activity |
| H | 0050661 | molecular_function | NADP binding |
| H | 0097171 | biological_process | ADP-L-glycero-beta-D-manno-heptose biosynthetic process |
| I | 0005975 | biological_process | carbohydrate metabolic process |
| I | 0008712 | molecular_function | ADP-glyceromanno-heptose 6-epimerase activity |
| I | 0016853 | molecular_function | isomerase activity |
| I | 0050661 | molecular_function | NADP binding |
| I | 0097171 | biological_process | ADP-L-glycero-beta-D-manno-heptose biosynthetic process |
| J | 0005975 | biological_process | carbohydrate metabolic process |
| J | 0008712 | molecular_function | ADP-glyceromanno-heptose 6-epimerase activity |
| J | 0016853 | molecular_function | isomerase activity |
| J | 0050661 | molecular_function | NADP binding |
| J | 0097171 | biological_process | ADP-L-glycero-beta-D-manno-heptose biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE NAP A 401 |
| Chain | Residue |
| A | GLY7 |
| A | GLY76 |
| A | ALA77 |
| A | SER79 |
| A | ASN92 |
| A | TYR96 |
| A | ALA114 |
| A | SER115 |
| A | SER116 |
| A | TYR139 |
| A | LYS143 |
| A | GLY10 |
| A | TYR166 |
| A | PHE167 |
| A | VAL169 |
| A | HIS176 |
| A | LYS177 |
| A | HOH502 |
| A | HOH506 |
| A | HOH533 |
| A | PHE11 |
| A | ILE12 |
| A | ASP32 |
| A | ASN33 |
| A | LYS39 |
| A | LYS54 |
| A | GLU75 |
| site_id | AC2 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE NAP B 401 |
| Chain | Residue |
| B | GLY7 |
| B | GLY10 |
| B | PHE11 |
| B | ILE12 |
| B | ASP32 |
| B | ASN33 |
| B | LYS39 |
| B | LYS54 |
| B | GLU75 |
| B | GLY76 |
| B | ALA77 |
| B | SER79 |
| B | ASN92 |
| B | TYR96 |
| B | ALA114 |
| B | SER115 |
| B | SER116 |
| B | TYR139 |
| B | LYS143 |
| B | TYR166 |
| B | PHE167 |
| B | VAL169 |
| B | HIS176 |
| B | LYS177 |
| B | HOH501 |
| B | HOH503 |
| site_id | AC3 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE NAP C 401 |
| Chain | Residue |
| C | GLY7 |
| C | GLY10 |
| C | PHE11 |
| C | ILE12 |
| C | ASP32 |
| C | ASN33 |
| C | LYS39 |
| C | LYS54 |
| C | GLU75 |
| C | GLY76 |
| C | ALA77 |
| C | SER79 |
| C | ASN92 |
| C | TYR96 |
| C | SER115 |
| C | SER116 |
| C | TYR139 |
| C | LYS143 |
| C | TYR166 |
| C | PHE167 |
| C | VAL169 |
| C | HIS176 |
| C | LYS177 |
| C | HOH501 |
| site_id | AC4 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE NAP D 401 |
| Chain | Residue |
| D | VAL169 |
| D | HIS176 |
| D | LYS177 |
| D | HOH513 |
| D | HOH544 |
| D | HOH546 |
| D | GLY7 |
| D | GLY10 |
| D | PHE11 |
| D | ILE12 |
| D | ASP32 |
| D | ASN33 |
| D | LYS39 |
| D | LYS54 |
| D | GLU75 |
| D | GLY76 |
| D | ALA77 |
| D | CYS78 |
| D | SER79 |
| D | ASN92 |
| D | TYR96 |
| D | ALA114 |
| D | SER115 |
| D | SER116 |
| D | TYR139 |
| D | LYS143 |
| D | TYR166 |
| D | PHE167 |
| site_id | AC5 |
| Number of Residues | 30 |
| Details | BINDING SITE FOR RESIDUE NAP E 401 |
| Chain | Residue |
| E | GLY7 |
| E | GLY10 |
| E | PHE11 |
| E | ILE12 |
| E | ASP32 |
| E | ASN33 |
| E | ARG36 |
| E | LYS39 |
| E | LYS54 |
| E | GLU75 |
| E | GLY76 |
| E | ALA77 |
| E | CYS78 |
| E | SER79 |
| E | ASN92 |
| E | TYR96 |
| E | ALA114 |
| E | SER115 |
| E | SER116 |
| E | TYR139 |
| E | LYS143 |
| E | TYR166 |
| E | PHE167 |
| E | VAL169 |
| E | HIS176 |
| E | LYS177 |
| E | HOH501 |
| E | HOH511 |
| E | HOH526 |
| E | HOH553 |
| site_id | AC6 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE NAP F 401 |
| Chain | Residue |
| F | GLY7 |
| F | GLY10 |
| F | PHE11 |
| F | ILE12 |
| F | ASP32 |
| F | ASN33 |
| F | LYS39 |
| F | LYS54 |
| F | GLU75 |
| F | GLY76 |
| F | ALA77 |
| F | SER79 |
| F | ASN92 |
| F | TYR96 |
| F | ALA114 |
| F | SER115 |
| F | SER116 |
| F | TYR139 |
| F | LYS143 |
| F | TYR166 |
| F | PHE167 |
| F | VAL169 |
| F | HIS176 |
| F | LYS177 |
| F | HOH505 |
| F | HOH539 |
| F | HOH544 |
| F | HOH550 |
| site_id | AC7 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE NAP G 401 |
| Chain | Residue |
| G | GLY7 |
| G | GLY10 |
| G | PHE11 |
| G | ILE12 |
| G | ASP32 |
| G | ASN33 |
| G | LYS39 |
| G | LYS54 |
| G | GLU75 |
| G | GLY76 |
| G | ALA77 |
| G | CYS78 |
| G | SER79 |
| G | ASN92 |
| G | TYR96 |
| G | ALA114 |
| G | SER115 |
| G | SER116 |
| G | TYR139 |
| G | LYS143 |
| G | TYR166 |
| G | PHE167 |
| G | VAL169 |
| G | HIS176 |
| G | LYS177 |
| G | HOH504 |
| G | HOH530 |
| G | HOH534 |
| G | HOH563 |
| site_id | AC8 |
| Number of Residues | 30 |
| Details | BINDING SITE FOR RESIDUE NAP H 401 |
| Chain | Residue |
| H | GLY7 |
| H | GLY10 |
| H | PHE11 |
| H | ILE12 |
| H | ASP32 |
| H | ASN33 |
| H | LYS39 |
| H | LYS54 |
| H | GLU75 |
| H | GLY76 |
| H | ALA77 |
| H | CYS78 |
| H | SER79 |
| H | ASN92 |
| H | TYR96 |
| H | ALA114 |
| H | SER115 |
| H | SER116 |
| H | TYR139 |
| H | LYS143 |
| H | TYR166 |
| H | PHE167 |
| H | VAL169 |
| H | HIS176 |
| H | LYS177 |
| H | HOH502 |
| H | HOH511 |
| H | HOH513 |
| H | HOH514 |
| H | HOH527 |
| site_id | AC9 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE NAP I 401 |
| Chain | Residue |
| I | GLY7 |
| I | GLY10 |
| I | PHE11 |
| I | ILE12 |
| I | ASP32 |
| I | ASN33 |
| I | LYS39 |
| I | LYS54 |
| I | GLU75 |
| I | GLY76 |
| I | ALA77 |
| I | SER79 |
| I | ASN92 |
| I | TYR96 |
| I | ALA114 |
| I | SER115 |
| I | SER116 |
| I | TYR139 |
| I | LYS143 |
| I | TYR166 |
| I | PHE167 |
| I | VAL169 |
| I | HIS176 |
| I | LYS177 |
| I | HOH501 |
| I | HOH511 |
| I | HOH517 |
| site_id | BC1 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE NAP J 401 |
| Chain | Residue |
| J | GLY7 |
| J | GLY10 |
| J | PHE11 |
| J | ILE12 |
| J | ASP32 |
| J | ASN33 |
| J | LYS39 |
| J | LYS54 |
| J | GLU75 |
| J | GLY76 |
| J | ALA77 |
| J | SER79 |
| J | ASN92 |
| J | TYR96 |
| J | ALA114 |
| J | SER115 |
| J | SER116 |
| J | TYR139 |
| J | LYS143 |
| J | TYR166 |
| J | PHE167 |
| J | VAL169 |
| J | HIS176 |
| J | LYS177 |
| J | HOH507 |
| J | HOH520 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_01601 |
| Chain | Residue | Details |
| A | TYR139 | |
| E | LYS177 | |
| F | TYR139 | |
| F | LYS177 | |
| G | TYR139 | |
| G | LYS177 | |
| H | TYR139 | |
| H | LYS177 | |
| I | TYR139 | |
| I | LYS177 | |
| J | TYR139 | |
| A | LYS177 | |
| J | LYS177 | |
| B | TYR139 | |
| B | LYS177 | |
| C | TYR139 | |
| C | LYS177 | |
| D | TYR139 | |
| D | LYS177 | |
| E | TYR139 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 150 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01601 |
| Chain | Residue | Details |
| A | PHE11 | |
| A | LYS177 | |
| G | LYS177 | |
| G | ARG179 | |
| G | HIS186 | |
| G | PHE200 | |
| G | ARG213 | |
| G | TYR292 | |
| H | PHE11 | |
| H | ASP32 | |
| H | LYS39 | |
| H | LYS54 | |
| A | ARG179 | |
| H | GLU75 | |
| H | ASN92 | |
| H | LYS143 | |
| H | ASN168 | |
| H | VAL169 | |
| H | LYS177 | |
| H | ARG179 | |
| H | HIS186 | |
| H | PHE200 | |
| H | ARG213 | |
| A | HIS186 | |
| H | TYR292 | |
| I | PHE11 | |
| I | ASP32 | |
| I | LYS39 | |
| I | LYS54 | |
| I | GLU75 | |
| I | ASN92 | |
| I | LYS143 | |
| I | ASN168 | |
| I | VAL169 | |
| A | PHE200 | |
| I | LYS177 | |
| I | ARG179 | |
| I | HIS186 | |
| I | PHE200 | |
| I | ARG213 | |
| I | TYR292 | |
| J | PHE11 | |
| J | ASP32 | |
| J | LYS39 | |
| J | LYS54 | |
| A | ARG213 | |
| J | GLU75 | |
| J | ASN92 | |
| J | LYS143 | |
| J | ASN168 | |
| J | VAL169 | |
| J | LYS177 | |
| J | ARG179 | |
| J | HIS186 | |
| J | PHE200 | |
| J | ARG213 | |
| A | TYR292 | |
| J | TYR292 | |
| B | PHE11 | |
| B | ASP32 | |
| B | LYS39 | |
| B | LYS54 | |
| A | ASP32 | |
| B | GLU75 | |
| B | ASN92 | |
| B | LYS143 | |
| B | ASN168 | |
| B | VAL169 | |
| B | LYS177 | |
| B | ARG179 | |
| B | HIS186 | |
| B | PHE200 | |
| B | ARG213 | |
| A | LYS39 | |
| B | TYR292 | |
| C | PHE11 | |
| C | ASP32 | |
| C | LYS39 | |
| C | LYS54 | |
| C | GLU75 | |
| C | ASN92 | |
| C | LYS143 | |
| C | ASN168 | |
| C | VAL169 | |
| A | LYS54 | |
| C | LYS177 | |
| C | ARG179 | |
| C | HIS186 | |
| C | PHE200 | |
| C | ARG213 | |
| C | TYR292 | |
| D | PHE11 | |
| D | ASP32 | |
| D | LYS39 | |
| D | LYS54 | |
| A | GLU75 | |
| D | GLU75 | |
| D | ASN92 | |
| D | LYS143 | |
| D | ASN168 | |
| D | VAL169 | |
| D | LYS177 | |
| D | ARG179 | |
| D | HIS186 | |
| D | PHE200 | |
| D | ARG213 | |
| A | ASN92 | |
| D | TYR292 | |
| E | PHE11 | |
| E | ASP32 | |
| E | LYS39 | |
| E | LYS54 | |
| E | GLU75 | |
| E | ASN92 | |
| E | LYS143 | |
| E | ASN168 | |
| E | VAL169 | |
| A | LYS143 | |
| E | LYS177 | |
| E | ARG179 | |
| E | HIS186 | |
| E | PHE200 | |
| E | ARG213 | |
| E | TYR292 | |
| F | PHE11 | |
| F | ASP32 | |
| F | LYS39 | |
| F | LYS54 | |
| A | ASN168 | |
| F | GLU75 | |
| F | ASN92 | |
| F | LYS143 | |
| F | ASN168 | |
| F | VAL169 | |
| F | LYS177 | |
| F | ARG179 | |
| F | HIS186 | |
| F | PHE200 | |
| F | ARG213 | |
| A | VAL169 | |
| F | TYR292 | |
| G | PHE11 | |
| G | ASP32 | |
| G | LYS39 | |
| G | LYS54 | |
| G | GLU75 | |
| G | ASN92 | |
| G | LYS143 | |
| G | ASN168 | |
| G | VAL169 |
