4EHY

Crystal structure of LpxK from Aquifex aeolicus in complex with ADP/Mg2+ at 2.2 angstrom resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005524	molecular_function	ATP binding
A	0005886	cellular_component	plasma membrane
A	0006629	biological_process	lipid metabolic process
A	0009029	molecular_function	lipid-A 4'-kinase activity
A	0009244	biological_process	lipopolysaccharide core region biosynthetic process
A	0009245	biological_process	lipid A biosynthetic process
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	27
Details	BINDING SITE FOR RESIDUE ADP A 401

Chain	Residue
A	GLY48
A	PHE208
A	LEU235
A	GLY236
A	GLN240
A	PHE241
A	VAL244
A	THR278
A	PRO279
A	LYS280
A	LEU294
A	SER49
A	PHE296
A	MG403
A	HOH501
A	HOH502
A	HOH504
A	HOH506
A	HOH507
A	HOH508
A	GLY50
A	LYS51
A	THR52
A	SER53
A	GLU100
A	LEU103
A	ARG206

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 402

Chain	Residue
A	SER53
A	ARG206
A	HOH507
A	HOH508

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site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 403

Chain	Residue
A	GLU100
A	ADP401
A	HOH501
A	HOH502
A	HOH503
A	HOH504

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site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL A 404

Chain	Residue
A	GLY88
A	LEU90

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site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL A 405

Chain	Residue
A	GLU189
A	ASN247

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site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE GOL A 406

Chain	Residue
A	GLY272

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00409","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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