4EFC
Crystal Structure of Adenylosuccinate Lyase from Trypanosoma Brucei, Tb427tmp.160.5560
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004018 | molecular_function | N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006163 | biological_process | purine nucleotide metabolic process |
| A | 0006188 | biological_process | IMP biosynthetic process |
| A | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| A | 0009152 | biological_process | purine ribonucleotide biosynthetic process |
| A | 0020015 | cellular_component | glycosome |
| A | 0044208 | biological_process | 'de novo' AMP biosynthetic process |
| A | 0070626 | molecular_function | (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity |
| A | 0097740 | cellular_component | paraflagellar rod |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004018 | molecular_function | N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006163 | biological_process | purine nucleotide metabolic process |
| B | 0006188 | biological_process | IMP biosynthetic process |
| B | 0006189 | biological_process | 'de novo' IMP biosynthetic process |
| B | 0009152 | biological_process | purine ribonucleotide biosynthetic process |
| B | 0020015 | cellular_component | glycosome |
| B | 0044208 | biological_process | 'de novo' AMP biosynthetic process |
| B | 0070626 | molecular_function | (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity |
| B | 0097740 | cellular_component | paraflagellar rod |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE AMP A 501 |
| Chain | Residue |
| A | ASN106 |
| A | THR356 |
| A | ARG359 |
| A | HOH605 |
| A | HOH606 |
| A | HOH627 |
| A | HOH673 |
| A | HOH700 |
| A | HOH870 |
| B | ARG29 |
| B | TYR30 |
| A | HIS107 |
| B | GLY309 |
| B | ILE320 |
| B | ASN324 |
| B | EDO502 |
| A | ASP108 |
| A | SER138 |
| A | GLN139 |
| A | HIS185 |
| A | GLN262 |
| A | ARG350 |
| A | SER355 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 502 |
| Chain | Residue |
| A | ASP285 |
| A | ASP289 |
| A | SER346 |
| A | LEU348 |
| A | HOH691 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO A 503 |
| Chain | Residue |
| A | SER310 |
| A | MET313 |
| A | LYS316 |
| A | ASN318 |
| B | THR184 |
| B | HIS185 |
| B | GLN262 |
| B | AMP501 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 504 |
| Chain | Residue |
| A | ARG72 |
| A | HOH954 |
| A | HOH972 |
| A | HOH973 |
| site_id | AC5 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE AMP B 501 |
| Chain | Residue |
| A | ARG29 |
| A | TYR30 |
| A | GLY309 |
| A | ILE320 |
| A | ASN324 |
| A | EDO503 |
| B | ASN106 |
| B | HIS107 |
| B | ASP108 |
| B | SER138 |
| B | GLN139 |
| B | HIS185 |
| B | GLN262 |
| B | ARG350 |
| B | LEU352 |
| B | SER355 |
| B | THR356 |
| B | ARG359 |
| B | HOH613 |
| B | HOH627 |
| B | HOH644 |
| B | HOH655 |
| B | HOH672 |
| B | HOH736 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO B 502 |
| Chain | Residue |
| A | THR184 |
| A | HIS185 |
| A | GLN262 |
| A | AMP501 |
| B | SER310 |
| B | MET313 |
| B | LYS316 |
| B | ASN318 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 503 |
| Chain | Residue |
| B | ASP285 |
| B | ASP289 |
| B | SER346 |
| B | LEU348 |
| B | HOH897 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA B 504 |
| Chain | Residue |
| B | ASP274 |
| B | ASN337 |
| B | HOH639 |
| B | HOH661 |
| B | HOH664 |
| B | HOH664 |
Functional Information from PROSITE/UniProt
