4EF9
Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with 4-Nitrophenyl isothiocyanate
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0004152 | molecular_function | dihydroorotate dehydrogenase activity |
A | 0005654 | cellular_component | nucleoplasm |
A | 0005737 | cellular_component | cytoplasm |
A | 0006106 | biological_process | fumarate metabolic process |
A | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
A | 0006222 | biological_process | UMP biosynthetic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
A | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
A | 0097014 | cellular_component | ciliary plasm |
A | 1990663 | molecular_function | dihydroorotate dehydrogenase (fumarate) activity |
B | 0000166 | molecular_function | nucleotide binding |
B | 0004152 | molecular_function | dihydroorotate dehydrogenase activity |
B | 0005654 | cellular_component | nucleoplasm |
B | 0005737 | cellular_component | cytoplasm |
B | 0006106 | biological_process | fumarate metabolic process |
B | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
B | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
B | 0006222 | biological_process | UMP biosynthetic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
B | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
B | 0097014 | cellular_component | ciliary plasm |
B | 1990663 | molecular_function | dihydroorotate dehydrogenase (fumarate) activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE 4NF A 401 |
Chain | Residue |
A | GLY101 |
A | LEU102 |
A | SER103 |
A | MET104 |
A | ASN107 |
A | VAL140 |
A | CYS150 |
A | HOH732 |
site_id | AC2 |
Number of Residues | 24 |
Details | BINDING SITE FOR RESIDUE FMN A 402 |
Chain | Residue |
A | ALA20 |
A | GLY21 |
A | LYS44 |
A | SER45 |
A | ASN68 |
A | MET70 |
A | ASN128 |
A | LYS165 |
A | ILE194 |
A | ASN195 |
A | GLY222 |
A | GLY223 |
A | VAL226 |
A | CYS249 |
A | GLY250 |
A | GLY251 |
A | GLY272 |
A | THR273 |
A | SO4403 |
A | HOH504 |
A | HOH516 |
A | HOH517 |
A | HOH525 |
A | ALA19 |
site_id | AC3 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE SO4 A 403 |
Chain | Residue |
A | LYS44 |
A | ASN68 |
A | MET70 |
A | GLY71 |
A | LEU72 |
A | PRO73 |
A | CYS131 |
A | ASN133 |
A | FMN402 |
A | HOH501 |
site_id | AC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 A 404 |
Chain | Residue |
A | HIS160 |
A | SER161 |
A | HOH643 |
site_id | AC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GOL A 405 |
Chain | Residue |
A | ILE203 |
A | SO4408 |
A | HOH562 |
A | HOH568 |
B | LEU231 |
site_id | AC6 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE SO4 A 406 |
Chain | Residue |
A | THR25 |
A | ARG51 |
A | PRO73 |
A | ASN74 |
A | ASN75 |
A | HOH593 |
A | HOH632 |
site_id | AC7 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE SO4 A 407 |
Chain | Residue |
A | TYR59 |
A | HOH574 |
site_id | AC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 A 408 |
Chain | Residue |
A | VAL202 |
A | ILE203 |
A | ASP204 |
A | ARG298 |
A | GOL405 |
A | HOH764 |
site_id | AC9 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE 4NF B 401 |
Chain | Residue |
B | GLY101 |
B | LEU102 |
B | SER103 |
B | MET104 |
B | ASN107 |
B | LYS137 |
B | PRO138 |
B | VAL140 |
B | CYS150 |
B | HOH631 |
site_id | BC1 |
Number of Residues | 24 |
Details | BINDING SITE FOR RESIDUE FMN B 402 |
Chain | Residue |
B | ALA19 |
B | ALA20 |
B | GLY21 |
B | LYS44 |
B | SER45 |
B | ASN68 |
B | MET70 |
B | ASN128 |
B | LYS165 |
B | ILE194 |
B | ASN195 |
B | GLY222 |
B | GLY223 |
B | VAL226 |
B | CYS249 |
B | GLY250 |
B | GLY251 |
B | GLY272 |
B | THR273 |
B | SO4403 |
B | HOH504 |
B | HOH508 |
B | HOH514 |
B | HOH515 |
site_id | BC2 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE SO4 B 403 |
Chain | Residue |
B | LYS44 |
B | ASN68 |
B | MET70 |
B | GLY71 |
B | LEU72 |
B | CYS131 |
B | ASN133 |
B | FMN402 |
B | HOH501 |
site_id | BC3 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL B 404 |
Chain | Residue |
A | LEU227 |
A | LEU231 |
A | HOH613 |
B | VAL202 |
B | ILE203 |
B | HOH712 |
B | HOH750 |
site_id | BC4 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE SO4 B 405 |
Chain | Residue |
B | THR25 |
B | ARG51 |
B | PRO73 |
B | ASN74 |
B | ASN75 |
B | HOH569 |
B | HOH648 |
B | HOH709 |