4EF9
Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with 4-Nitrophenyl isothiocyanate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004152 | molecular_function | dihydroorotate dehydrogenase activity |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006106 | biological_process | fumarate metabolic process |
| A | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| A | 0006222 | biological_process | UMP biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
| A | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| A | 0097014 | cellular_component | ciliary plasm |
| A | 1990663 | molecular_function | dihydroorotate dehydrogenase (fumarate) activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004152 | molecular_function | dihydroorotate dehydrogenase activity |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006106 | biological_process | fumarate metabolic process |
| B | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| B | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| B | 0006222 | biological_process | UMP biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
| B | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| B | 0097014 | cellular_component | ciliary plasm |
| B | 1990663 | molecular_function | dihydroorotate dehydrogenase (fumarate) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE 4NF A 401 |
| Chain | Residue |
| A | GLY101 |
| A | LEU102 |
| A | SER103 |
| A | MET104 |
| A | ASN107 |
| A | VAL140 |
| A | CYS150 |
| A | HOH732 |
| site_id | AC2 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE FMN A 402 |
| Chain | Residue |
| A | ALA20 |
| A | GLY21 |
| A | LYS44 |
| A | SER45 |
| A | ASN68 |
| A | MET70 |
| A | ASN128 |
| A | LYS165 |
| A | ILE194 |
| A | ASN195 |
| A | GLY222 |
| A | GLY223 |
| A | VAL226 |
| A | CYS249 |
| A | GLY250 |
| A | GLY251 |
| A | GLY272 |
| A | THR273 |
| A | SO4403 |
| A | HOH504 |
| A | HOH516 |
| A | HOH517 |
| A | HOH525 |
| A | ALA19 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 A 403 |
| Chain | Residue |
| A | LYS44 |
| A | ASN68 |
| A | MET70 |
| A | GLY71 |
| A | LEU72 |
| A | PRO73 |
| A | CYS131 |
| A | ASN133 |
| A | FMN402 |
| A | HOH501 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 404 |
| Chain | Residue |
| A | HIS160 |
| A | SER161 |
| A | HOH643 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 405 |
| Chain | Residue |
| A | ILE203 |
| A | SO4408 |
| A | HOH562 |
| A | HOH568 |
| B | LEU231 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 406 |
| Chain | Residue |
| A | THR25 |
| A | ARG51 |
| A | PRO73 |
| A | ASN74 |
| A | ASN75 |
| A | HOH593 |
| A | HOH632 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 407 |
| Chain | Residue |
| A | TYR59 |
| A | HOH574 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 408 |
| Chain | Residue |
| A | VAL202 |
| A | ILE203 |
| A | ASP204 |
| A | ARG298 |
| A | GOL405 |
| A | HOH764 |
| site_id | AC9 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE 4NF B 401 |
| Chain | Residue |
| B | GLY101 |
| B | LEU102 |
| B | SER103 |
| B | MET104 |
| B | ASN107 |
| B | LYS137 |
| B | PRO138 |
| B | VAL140 |
| B | CYS150 |
| B | HOH631 |
| site_id | BC1 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE FMN B 402 |
| Chain | Residue |
| B | ALA19 |
| B | ALA20 |
| B | GLY21 |
| B | LYS44 |
| B | SER45 |
| B | ASN68 |
| B | MET70 |
| B | ASN128 |
| B | LYS165 |
| B | ILE194 |
| B | ASN195 |
| B | GLY222 |
| B | GLY223 |
| B | VAL226 |
| B | CYS249 |
| B | GLY250 |
| B | GLY251 |
| B | GLY272 |
| B | THR273 |
| B | SO4403 |
| B | HOH504 |
| B | HOH508 |
| B | HOH514 |
| B | HOH515 |
| site_id | BC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 B 403 |
| Chain | Residue |
| B | LYS44 |
| B | ASN68 |
| B | MET70 |
| B | GLY71 |
| B | LEU72 |
| B | CYS131 |
| B | ASN133 |
| B | FMN402 |
| B | HOH501 |
| site_id | BC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 404 |
| Chain | Residue |
| A | LEU227 |
| A | LEU231 |
| A | HOH613 |
| B | VAL202 |
| B | ILE203 |
| B | HOH712 |
| B | HOH750 |
| site_id | BC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B 405 |
| Chain | Residue |
| B | THR25 |
| B | ARG51 |
| B | PRO73 |
| B | ASN74 |
| B | ASN75 |
| B | HOH569 |
| B | HOH648 |
| B | HOH709 |
