4EF4
Crystal structure of STING CTD complex with c-di-GMP
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0002218 | biological_process | activation of innate immune response |
A | 0032481 | biological_process | positive regulation of type I interferon production |
B | 0002218 | biological_process | activation of innate immune response |
B | 0032481 | biological_process | positive regulation of type I interferon production |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE C2E A 401 |
Chain | Residue |
A | SER162 |
A | HOH550 |
B | SER162 |
B | GLY166 |
B | TYR167 |
B | THR263 |
B | PRO264 |
A | TYR167 |
A | GLU260 |
A | THR263 |
A | PRO264 |
A | HOH501 |
A | HOH502 |
A | HOH503 |
A | HOH520 |
site_id | AC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CA A 402 |
Chain | Residue |
A | ASP205 |
A | GLU316 |
A | HOH506 |
A | HOH544 |
A | HOH546 |
site_id | AC3 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE CA B 401 |
Chain | Residue |
B | VAL341 |
B | HOH536 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:22728660, ECO:0007744|PDB:4F5Y |
Chain | Residue | Details |
A | SER162 | |
B | SER162 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:22579474, ECO:0000269|PubMed:22705373, ECO:0000269|PubMed:22728658, ECO:0000269|PubMed:22728659, ECO:0000269|PubMed:22728660, ECO:0007744|PDB:4EF4, ECO:0007744|PDB:4EMT, ECO:0007744|PDB:4F5D, ECO:0007744|PDB:4F5Y, ECO:0007744|PDB:4F9G |
Chain | Residue | Details |
A | TYR167 | |
B | TYR167 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:37379839, ECO:0007744|PDB:8GJX |
Chain | Residue | Details |
A | ARG238 | |
B | ARG238 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:22579474, ECO:0000269|PubMed:22705373, ECO:0000269|PubMed:22728658, ECO:0000269|PubMed:22728660, ECO:0007744|PDB:4EF4, ECO:0007744|PDB:4EMT, ECO:0007744|PDB:4F5Y, ECO:0007744|PDB:4F9G |
Chain | Residue | Details |
A | THR263 | |
B | THR263 |
site_id | SWS_FT_FI5 |
Number of Residues | 6 |
Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:37832545 |
Chain | Residue | Details |
A | THR229 | |
A | THR354 | |
A | THR356 | |
B | THR229 | |
B | THR354 | |
B | THR356 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:37832545 |
Chain | Residue | Details |
A | SER241 | |
B | SER241 |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine; by MAP3K7 => ECO:0000269|PubMed:37832545 |
Chain | Residue | Details |
A | SER355 | |
B | SER355 |
site_id | SWS_FT_FI8 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine; by TBK1 => ECO:0000269|PubMed:18818105, ECO:0000269|PubMed:25636800 |
Chain | Residue | Details |
A | SER358 | |
B | SER358 |
site_id | SWS_FT_FI9 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine; by TBK1 => ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27302953, ECO:0000269|PubMed:32753499 |
Chain | Residue | Details |
A | SER366 | |
B | SER366 |
site_id | SWS_FT_FI10 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:19285439, ECO:0000269|PubMed:21074459 |
Chain | Residue | Details |
A | LYS150 | |
B | LYS150 |
site_id | SWS_FT_FI11 |
Number of Residues | 4 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000250|UniProtKB:Q3TBT3 |
Chain | Residue | Details |
A | LYS338 | |
B | LYS338 |
site_id | SWS_FT_FI12 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:31968013 |
Chain | Residue | Details |
A | LYS236 | |
B | LYS236 |