Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4EEB

CorA coiled-coil mutant under Mg2+ absence

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006824	biological_process	cobalt ion transport
A	0015087	molecular_function	cobalt ion transmembrane transporter activity
A	0015095	molecular_function	magnesium ion transmembrane transporter activity
A	0015693	biological_process	magnesium ion transport
A	0016020	cellular_component	membrane
A	0030001	biological_process	metal ion transport
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
A	0046873	molecular_function	metal ion transmembrane transporter activity
A	0050897	molecular_function	cobalt ion binding
A	0051260	biological_process	protein homooligomerization
A	0055085	biological_process	transmembrane transport
A	1903830	biological_process	magnesium ion transmembrane transport
B	0000287	molecular_function	magnesium ion binding
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006824	biological_process	cobalt ion transport
B	0015087	molecular_function	cobalt ion transmembrane transporter activity
B	0015095	molecular_function	magnesium ion transmembrane transporter activity
B	0015693	biological_process	magnesium ion transport
B	0016020	cellular_component	membrane
B	0030001	biological_process	metal ion transport
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
B	0046873	molecular_function	metal ion transmembrane transporter activity
B	0050897	molecular_function	cobalt ion binding
B	0051260	biological_process	protein homooligomerization
B	0055085	biological_process	transmembrane transport
B	1903830	biological_process	magnesium ion transmembrane transport
C	0000287	molecular_function	magnesium ion binding
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006824	biological_process	cobalt ion transport
C	0015087	molecular_function	cobalt ion transmembrane transporter activity
C	0015095	molecular_function	magnesium ion transmembrane transporter activity
C	0015693	biological_process	magnesium ion transport
C	0016020	cellular_component	membrane
C	0030001	biological_process	metal ion transport
C	0042802	molecular_function	identical protein binding
C	0046872	molecular_function	metal ion binding
C	0046873	molecular_function	metal ion transmembrane transporter activity
C	0050897	molecular_function	cobalt ion binding
C	0051260	biological_process	protein homooligomerization
C	0055085	biological_process	transmembrane transport
C	1903830	biological_process	magnesium ion transmembrane transport
D	0000287	molecular_function	magnesium ion binding
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0006824	biological_process	cobalt ion transport
D	0015087	molecular_function	cobalt ion transmembrane transporter activity
D	0015095	molecular_function	magnesium ion transmembrane transporter activity
D	0015693	biological_process	magnesium ion transport
D	0016020	cellular_component	membrane
D	0030001	biological_process	metal ion transport
D	0042802	molecular_function	identical protein binding
D	0046872	molecular_function	metal ion binding
D	0046873	molecular_function	metal ion transmembrane transporter activity
D	0050897	molecular_function	cobalt ion binding
D	0051260	biological_process	protein homooligomerization
D	0055085	biological_process	transmembrane transport
D	1903830	biological_process	magnesium ion transmembrane transport
E	0000287	molecular_function	magnesium ion binding
E	0005886	cellular_component	plasma membrane
E	0006811	biological_process	monoatomic ion transport
E	0006824	biological_process	cobalt ion transport
E	0015087	molecular_function	cobalt ion transmembrane transporter activity
E	0015095	molecular_function	magnesium ion transmembrane transporter activity
E	0015693	biological_process	magnesium ion transport
E	0016020	cellular_component	membrane
E	0030001	biological_process	metal ion transport
E	0042802	molecular_function	identical protein binding
E	0046872	molecular_function	metal ion binding
E	0046873	molecular_function	metal ion transmembrane transporter activity
E	0050897	molecular_function	cobalt ion binding
E	0051260	biological_process	protein homooligomerization
E	0055085	biological_process	transmembrane transport
E	1903830	biological_process	magnesium ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CS A 401

Chain	Residue
A	ASN314
E	ASN314

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CS B 1001

Chain	Residue
B	HIS257
C	ASP89
C	GLN95

site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE NA B 1002

Chain	Residue
B	ASP277

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CS B 1003

Chain	Residue
B	ASP189

site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CS B 1004

Chain	Residue
B	ASP190

site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CS C 401

Chain	Residue
C	ASP253

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CS D 1001

Chain	Residue
D	HIS257
E	ASN92

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CS E 402

Chain	Residue
A	LEU85
A	GLU88
A	ASP89
E	ASP253

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	200
Details	TRANSMEM: Helical => ECO:0000269\|PubMed:16598263, ECO:0000269\|PubMed:16857941, ECO:0000269\|PubMed:16902408, ECO:0000269\|PubMed:23112165, ECO:0000269\|PubMed:23425532, ECO:0000269\|PubMed:26871634

Chain	Residue	Details
A	VAL293-MET313
E	TRP325-PHE345
A	TRP325-PHE345
B	VAL293-MET313
B	TRP325-PHE345
C	VAL293-MET313
C	TRP325-PHE345
D	VAL293-MET313
D	TRP325-PHE345
E	VAL293-MET313

site_id	SWS_FT_FI2
Number of Residues	50
Details	TOPO_DOM: Extracellular => ECO:0000305

Chain	Residue	Details
A	ASN314-LYS324
B	ASN314-LYS324
C	ASN314-LYS324
D	ASN314-LYS324
E	ASN314-LYS324

site_id	SWS_FT_FI3
Number of Residues	25
Details	TOPO_DOM: Cytoplasmic => ECO:0000305

Chain	Residue	Details
A	LYS346-LEU351
B	LYS346-LEU351
C	LYS346-LEU351
D	LYS346-LEU351
E	LYS346-LEU351

site_id	SWS_FT_FI4
Number of Residues	5
Details	SITE: Essential for ion permeation => ECO:0000269\|PubMed:23091000

Chain	Residue	Details
A	ASN288
B	ASN288
C	ASN288
D	ASN288
E	ASN288

site_id	SWS_FT_FI5
Number of Residues	5
Details	SITE: Important for closing the ion permeation pathway in the closed state => ECO:0000269\|PubMed:16598263, ECO:0000269\|PubMed:16857941, ECO:0000269\|PubMed:16902408, ECO:0000269\|PubMed:18276588

Chain	Residue	Details
A	LEU294
B	LEU294
C	LEU294
D	LEU294
E	LEU294

site_id	SWS_FT_FI6
Number of Residues	5
Details	SITE: Threonine that confers selectivity for Co(2+) transport => ECO:0000269\|PubMed:23425532

Chain	Residue	Details
A	THR295
B	THR295
C	THR295
D	THR295
E	THR295

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)