4ED3

Human DNA polymerase eta - DNA ternary complex: AT crystal at pH 7.5 (Na+ HEPES) with 1 Ca2+ ion

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003684	molecular_function	damaged DNA binding
A	0006281	biological_process	DNA repair

Functional Information from PDB Data

site_id	AC1
Number of Residues	26
Details	BINDING SITE FOR RESIDUE DTP P 501

Chain	Residue
A	ASP13
A	ARG55
A	ARG61
A	ASP115
A	LYS231
A	NA502
A	CA503
A	HOH604
A	HOH640
A	HOH647
A	HOH676
A	MET14
A	HOH709
A	HOH892
P	DT8
P	HOH101
T	DT3
T	DT4
T	DA5
A	ASP15
A	CYS16
A	PHE17
A	PHE18
A	ILE48
A	ALA49
A	TYR52

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE NA A 502

Chain	Residue
A	ASP13
A	SER113
A	ASP115
A	GLU116
A	CA503
A	HOH725
P	DT8
P	DTP501

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 503

Chain	Residue
A	ASP13
A	MET14
A	ASP115
A	NA502
P	DTP501

---

site_id	AC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL A 504

Chain	Residue
A	ARG24
A	PRO244
A	PHE247
A	SER248
A	GLY276
A	GLU277
A	HOH602
A	HOH634
A	HOH669
A	HOH715

---

site_id	AC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL A 505

Chain	Residue
A	GLU94
A	ALA95
A	GLU98
A	ARG303
A	HOH648
A	HOH651
A	HOH736
A	HOH801
A	HOH829
A	HOH849

---

site_id	AC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL A 506

Chain	Residue
A	ASN26
A	PRO27
A	HIS28
A	GLY271
A	ILE272
A	GLU273
A	TYR274
A	GLU277
A	HOH807
A	HOH915

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:27284197, ECO:0007744|PDB:5KFO

Chain	Residue	Details
A	ASP13
A	MET14
A	ASP115
A	GLU116

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:27284197

Chain	Residue	Details
A	ARG61

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