4EC7

Cobra NGF in complex with lipid

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004857	molecular_function	enzyme inhibitor activity
A	0005102	molecular_function	signaling receptor binding
A	0005163	molecular_function	nerve growth factor receptor binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0007169	biological_process	cell surface receptor protein tyrosine kinase signaling pathway
A	0008021	cellular_component	synaptic vesicle
A	0008083	molecular_function	growth factor activity
A	0008191	molecular_function	metalloendopeptidase inhibitor activity
A	0008289	molecular_function	lipid binding
A	0021675	biological_process	nerve development
A	0030414	molecular_function	peptidase inhibitor activity
A	0030424	cellular_component	axon
A	0030425	cellular_component	dendrite
A	0035821	biological_process	modulation of process of another organism
A	0038180	biological_process	nerve growth factor signaling pathway
A	0043524	biological_process	negative regulation of neuron apoptotic process
A	0048812	biological_process	neuron projection morphogenesis
A	0050804	biological_process	modulation of chemical synaptic transmission
A	0090729	molecular_function	toxin activity
B	0004857	molecular_function	enzyme inhibitor activity
B	0005102	molecular_function	signaling receptor binding
B	0005163	molecular_function	nerve growth factor receptor binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0007169	biological_process	cell surface receptor protein tyrosine kinase signaling pathway
B	0008021	cellular_component	synaptic vesicle
B	0008083	molecular_function	growth factor activity
B	0008191	molecular_function	metalloendopeptidase inhibitor activity
B	0008289	molecular_function	lipid binding
B	0021675	biological_process	nerve development
B	0030414	molecular_function	peptidase inhibitor activity
B	0030424	cellular_component	axon
B	0030425	cellular_component	dendrite
B	0035821	biological_process	modulation of process of another organism
B	0038180	biological_process	nerve growth factor signaling pathway
B	0043524	biological_process	negative regulation of neuron apoptotic process
B	0048812	biological_process	neuron projection morphogenesis
B	0050804	biological_process	modulation of chemical synaptic transmission
B	0090729	molecular_function	toxin activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE L44 A 200

Chain	Residue
A	LEU42
A	PHE99
A	HOH302
A	HOH308
B	GLU10
B	TRP20
B	TYR47
B	TYR50
B	LYS86
B	TRP97
A	TYR47
A	LYS48
A	GLU49
A	TYR50
A	TYR77
A	THR79
A	LYS86
A	TRP97

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Functional Information from PROSITE/UniProt

site_id	PS00248
Number of Residues	14
Details	NGF_1 Nerve growth factor family signature. GCRGIDsshWnSyC

Chain	Residue	Details
A	GLY65-CYS78

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22649032","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4EC7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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