4EBC

Conformationally Restrained North-methanocarba-2'-deoxyadenosine Corrects the Error-Prone Nature of Human DNA Polymerase Iota

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003684	molecular_function	damaged DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0006281	biological_process	DNA repair

Functional Information from PDB Data

site_id	AC1
Number of Residues	20
Details	BINDING SITE FOR RESIDUE 0OH A 501

Chain	Residue
A	ASP36
A	ASP126
A	CA502
A	CA504
A	HOH606
A	HOH615
A	HOH626
A	HOH644
A	HOH645
P	DOC7
T	DT4
A	CYS37
T	DG5
A	PHE38
A	TYR39
A	THR65
A	TYR68
A	ARG71
A	LYS77
A	LEU78

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA A 502

Chain	Residue
A	ASP34
A	LEU35
A	ASP126
A	0OH501

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 503

Chain	Residue
A	LYS237
A	ILE239
A	HOH619
A	HOH647
P	DC6
P	HOH105

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA A 504

Chain	Residue
A	ASP34
A	GLU127
A	0OH501
A	HOH603

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 505

Chain	Residue
A	GLU97
A	GLU304
A	SER327
A	HOH610
A	HOH656
T	DG6

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	213
Details	Domain: {"description":"UmuC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00216","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	65
Details	Region: {"description":"DNA-binding","evidences":[{"source":"PubMed","id":"15254543","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27555320","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T3N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KT2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KT4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KT6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00216","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27555320","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5KT5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15254543","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T3N","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---