4E89

Crystal Structure of RnaseH from gammaretrovirus

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0004523	molecular_function	RNA-DNA hybrid ribonuclease activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CD A 701

Chain	Residue
A	ASP511
A	ASP511
A	HIS592
A	HIS592

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CD A 702

Chain	Residue
A	HIS594
A	GLU596
A	CYS635
A	CD703

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CD A 703

Chain	Residue
A	CYS635
A	HIS638
A	GLU645
A	CD702
A	GLU596

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CD A 704

Chain	Residue
A	GLU545
A	ARG560
A	GLU616

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 705

Chain	Residue
A	ASP524
A	GLY525
A	GLU562
A	ASP583

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	146
Details	Domain: {"description":"RNase H type-1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00408","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00408","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"22252812","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22724525","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22252812","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00408","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---